In a test of the effectiveness of the invention, four middle-aged males with rapidly progressing baldness were treated orally with either 6g of evening primrose oil or 6g of a mixture of evening primrose oil and concentrated fish oil (20%) per day. The primrose oil provided approximately 90mg of 18:3n-6 (gamma-linolenic acid, GLA) per gram and the fish oil 180mg of 20:5n-3 (eicosapentaenoic acid, EPA) and 120mg of docosahexaenoic acid (DHA) per gram. After delays of 4 to 8 weeks, all four individuals reported unequivocal hair growth, with extension of hair growth to previously bald areas of the scalp, and a strengthening of growth in those areas where hair was present but thinning. Topical application of the unsaturated fatty acids provides better results by increasing the concentration of the fatty acid at the hair follicle level.
In further tests, one male applied pure evening primrose oil twice per day to half the beard area. After about two weeks, the rate of beard growth on the side of the face to which the oil had been applied was definitely less than on the other side. Similarly, one female shaved both legs and then applied evening primrose oil twice daily to one leg only. After a period of 6-8 weeks it could be seen that the rate of hair growth was substantially less on the leg to which the oil had been applied.
These preliminary tests indicate that both oral and topical application of unsaturated fatty acids is able to modulate the actions of androgens on the hair follicles, stimulating hair growth on the scalp and reducing it on other areas of the body.
I personally haven't tried it yet but will so soon...
and you are saying this works in pill form? just take one a day? the studies say it's been tried as a topical but how would you make this a topical?
02-13-2013 07:28 PM
2020
Quote:
Originally Posted by FearTheLoss
and you are saying this works in pill form? just take one a day? the studies say it's been tried as a topical but how would you make this a topical?
...
"...four middle-aged males with rapidly progressing baldness were treated orally..."
yes, why wouldn't it work? It just says that it might provide better results topically. Finasteride works orally too and likely would provide some results topically as well...
02-13-2013 07:32 PM
FearTheLoss
Quote:
Originally Posted by 2020
...
"...four middle-aged males with rapidly progressing baldness were treated orally..."
yes, why wouldn't it work? It just says that it might provide better results topically. Finasteride works orally too and likely would provide some results topically as well...
Alright I think I may try this? Are you going to start? just wondering why no one else has talked about this..
02-13-2013 07:44 PM
FearTheLoss
I just did some reading on this and you need GLA in free form, its pure form to work as a 5a-inhibitor...so these pills in the link won't work, if what I read was correct.
Androgen action in many organs, such as prostate and skin, is dependent on the conversion of testosterone by 5 alpha-reductase to 5 alpha-dihydrotestosterone. 5 alpha-Dihydrotestosterone then binds to the androgen receptor to regulate specific gene expression. Inhibitors of 5 alpha-reductase are useful for the selective treatment of prostatic cancer, benign prostate hyperplasia, acne, baldness and female hirsutism, without affecting spermatogenesis, sexual behavior and smooth muscle growth, that do not require the conversion of testosterone to 5 alpha-dihydrotestosterone. Certain unsaturated fatty acids, such as gamma-linolenic acid, are potent 5 alpha-reductase inhibitors, suggesting a linkage between unsaturated fatty acids and androgen action. Mutations in androgen receptor genes are responsible for many cases of androgen-insensitivity. In some prostate cancer cells, some antiandrogens may act like androgens in stimulating the proliferation of the cancer cells because these antiandrogens can bind to a mutated androgen receptor and transactivate target genes. Prostate cancers are usually androgen-dependent initially but can lose dependency and responsiveness. Tumor cells which are resistant to endocrine therapy ultimately proliferate. Androgen-independent or androgen-repressive cells can arise from androgen-sensitive prostate cancer cells by changes in specific gene expression over time in a clonal isolate. This change in androgen responsiveness was accompanied by a change in androgen receptor expression and transcriptional activity as well as expression of some oncogenes.
Studies Gamma Linolenic Acid, Alpha Linolenic Acid, and Linoleic Acid
In the following studies, Gamma Linolenic Acid (GLA), Alpha Linolenic Acid (ALA), and Linoleic Acid were shown to be the most potent known inhibitors of type 1 and 2 forms of 5-alpha reductase and highly effective in decreasing the levels of dihydrotestosterone (DHT). More importantly this is accomplished without affecting any systemic effects. The study further suggests that these fatty acids can be useful in the treatment of disorders related to dihydrotestosterone including male pattern baldness, acne, and excessive female body hair (hirsuitism).
So we need Borage oil+ Omega 3 fish oil with a lot of EPA DHA along with Sesamin oil internally= bad ass hairloss treatment.
