Hmm.. i don't know exactly what to say... It is good that they are still active on something, but it is disappointing that the newest finding they are announcing is not a breakthrough of hair follicle issue they were previous onto, but something irrelevant.
03-13-2016 04:42 AM
Desmond84
The Chinese have mastered Jahoda's technique and are rapidly developing methods to take it to clinical trials. Here's the paper they published last month:
Interestingly enough, DP cells maintained their Trichogenicity in passage 8 which is unheard of. Hair sprouted after expanding these cells 8 times. Let's see what more this year brings.
Important note: the DP cells used were human. They were just injected into mice! In before, another mouse study ;)
03-13-2016 07:41 AM
Arashi
Quote:
Originally Posted by Desmond84
The Chinese have mastered Jahoda's technique and are rapidly developing methods to take it to clinical trials. Here's the paper they published last month:
Interestingly enough, DP cells maintained their Trichogenicity in passage 8 which is unheard of. Hair sprouted after expanding these cells 8 times. Let's see what more this year brings.
Important note: the DP cells used were human. They were just injected into mice! In before, another mouse study ;)
8 passages, that's an accomplishment in itself indeed, nice to see this progress. However, key problem with Jahoda's achievements were the lack of correct cosmetic attributes like hair color and thickness. Does this article reveal anything here ?
03-13-2016 07:51 AM
allTheGoodNamesAreTaken
Quote:
Originally Posted by Desmond84
The Chinese have mastered Jahoda's technique and are rapidly developing methods to take it to clinical trials. Here's the paper they published last month:
Interestingly enough, DP cells maintained their Trichogenicity in passage 8 which is unheard of. Hair sprouted after expanding these cells 8 times. Let's see what more this year brings.
Important note: the DP cells used were human. They were just injected into mice! In before, another mouse study ;)
So how many 'passages' does it take before you have a working product?
03-13-2016 10:43 AM
Arashi
Quote:
Originally Posted by allTheGoodNamesAreTaken
So how many 'passages' does it take before you have a working product?
passages just means dividing cells. So you take a cell, make 2 out of them, now you have 2 cells after on passage. Then you this again and you have 4 cells after 2 passages. So 8 passages just means they managed to make 256 dp cells out of just 1 dp cell and all those cells still were able to induce a hair follicle.
03-13-2016 10:45 AM
nameless
Quote:
Originally Posted by Arashi
8 passages, that's an accomplishment in itself indeed, nice to see this progress. However, key problem with Jahoda's achievements were the lack of correct cosmetic attributes like hair color and thickness. Does this article reveal anything here ?
Arishi, two things:
1. The key problem with Jahoda's achievements are, and always have been, hair inductivity. It the Chinese have solved that problem then that should result in a breakthrough.
2. You were right about the big problem with adipose derived stem cells migrating out of the injected area. Science may have found a solution to that problem. Have you checked out Kerastem?
03-13-2016 10:48 AM
nameless
Quote:
Originally Posted by Desmond84
The Chinese have mastered Jahoda's technique and are rapidly developing methods to take it to clinical trials. Here's the paper they published last month:
Interestingly enough, DP cells maintained their Trichogenicity in passage 8 which is unheard of. Hair sprouted after expanding these cells 8 times. Let's see what more this year brings.
Important note: the DP cells used were human. They were just injected into mice! In before, another mouse study ;)
What are the Chinese doing that is different from what everyone else is doing? How can they maintain trichogenicity in passage 8? What is the difference between their technique and the technique of others that allows them to do P8 and maintain trichogenicity?
03-13-2016 11:28 AM
joachim
Quote:
Originally Posted by Desmond84
The Chinese have mastered Jahoda's technique and are rapidly developing methods to take it to clinical trials. Here's the paper they published last month:
Interestingly enough, DP cells maintained their Trichogenicity in passage 8 which is unheard of. Hair sprouted after expanding these cells 8 times. Let's see what more this year brings.
Important note: the DP cells used were human. They were just injected into mice! In before, another mouse study ;)
like arashi said, gene expression is probably not solved yet, it's just the trichogenicity part.
my feeling is that the hanging drop method will lead nowhere. transforming iPS into DP cells is the right way to go.
also, what happened to lausters team? are you still in contact with dr. beren atac or dr. lindner?
they practically have achieved nothing so far, it's so dissapointing and frustrating. and i even think, they are not trying hard enough anymore, they probably gave up. their focus is on lab-on-a-chip only. curing hairloss or seriously growing higher amounts of hair in vitro was never their real goal i think.
furthermore, meanwhile many other companies are already working on the lab-on-a-chip thing, so that lindners team is behind others as well.
all in all, i think we can close the book about dr. lauster, dr. linder, and all others related to TU Berlin. it's over. of course they will tinker around for many more years trying meaningless stuff in their labs. in the end it's a university, and they have to do some R&D with their funds. but who cares if anything comes of it or not. let them tinker around for another decade, as long as the jobs are secured, everything is fine.
my only hope is in replicel now, as their science seems to make sense. but still there are so many unknown variables.
histogen is still dead in my opinion, but they're trying to fool investors with their combover images. we are so screwed.
03-13-2016 01:35 PM
FooFighter
Its still mice and still wasting of time on nothing...
For now only: Replicel and Histogen!
03-13-2016 02:45 PM
Arashi
Quote:
Originally Posted by nameless
Arishi, two things:
1. The key problem with Jahoda's achievements are, and always have been, hair inductivity. It the Chinese have solved that problem then that should result in a breakthrough.
No. Jahoda already solved that. It's just that the resulting hair wasnt cosmetically viable. Like Joachim just said, gene expression wasnt good enough.