Why did Setipiprant win over Ramatroban / TM30089 ?!
Hello guys.
I recently wanted to mimic Swisstemple's protocol and was in search of a oral Pgd2 / CRTH2-Blocker besides Setipiprant, because i was kicked out of the groupbuy.
I did some pointless research on Quercetin and Resveratrol until i eventually gave up for the day. Later then, on another Forum, i found another hate-thread about Setipiprant and it's lacking of effectiveness, pictures, reports etc. and later a thread promoting TM30089, a compound i had heard about a few months ago.
I Researched that and eventually found Ramatroban, which is even linked as a 'related article' on the wiki page, but i had never noticed that.
Ramatroban was initially developed by Bayer and then distributed solely in Japan as drug against hayfever. It was discontinued. Now the supplier is 'Nippon Shinyaku Co. Ltd.'.
TM30089 is essentially the same as Ramatroban, except for the fact that it is far more specific to the CRTH2-receptor, bock it's blocking capabilities are quite fine.
https://www.caymanchem.com/app/templ...talog/10006735
http://prntscr.com/9gl6cf
http://www.ncbi.nlm.nih.gov/pubmed/16418339
to my question: why is everyone using Setipiprant in a hype then?! Why not just swallow a low dose TM30089 / Ramatroban and be done with it?