Cell. 2015 Apr 9;161(2):277-90. doi: 10.1016/j.cell.2015.02.016.
Organ-level quorum sensing directs regeneration in hair stem cell populations.
Chen CC1, Wang L2, Plikus MV3, Jiang TX4, Murray PJ5, Ramos R3, Guerrero-Juarez CF3, Hughes MW6, Lee OK7, Shi S8, Widelitz RB4, Lander AD9, Chuong CM10.
Author information
Abstract
Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regeneration of up to five times more neighboring, unplucked resting hairs, indicating activation of a collective decision-making process. Through data modeling, the range of the quorum signal was estimated to be on the order of 1 mm, greater than expected for a diffusible molecular cue. Molecular and genetic analysis uncovered a two-step mechanism, where release of CCL2 from injured hairs leads to recruitment of TNF-α-secreting macrophages, which accumulate and signal to both plucked and unplucked follicles. By coupling immune response with regeneration, this mechanism allows skin to respond predictively to distress, disregarding mild injury, while meeting stronger injury with full-scale cooperative activation of stem cells.
I didnt ask WHY you need to damage hair to grow it back...
I asked why you weren't making sure people who buy it know that all of their hair will fall out and they will have large red scabs all over their scalp... for up to 6+ months... that should probably be on the package....
04-14-2015 02:46 PM
joachim
if liu can't come up with any real results and solid science behind it, i think we should report him to the indiegogo moderators. such a scam treatment, and even unsafe treatment, should not reach its funding goal. people should be warned.
04-20-2015 07:40 AM
liuxuewu
Quote:
Originally Posted by joachim
if liu can't come up with any real results and solid science behind it, i think we should report him to the indiegogo moderators. such a scam treatment, and even unsafe treatment, should not reach its funding goal. people should be warned.
Please carefully read all chips, there are scientific explanations, and a number of the case. this product is a special cosmetics, already approved by the CFDA in China. You don't rely on how to judge whether it is a safe treatment. It is cosmetics are not drugs.
04-20-2015 07:42 AM
liuxuewu
Quote:
Originally Posted by NeedHairASAP
I didnt ask WHY you need to damage hair to grow it back...
I asked why you weren't making sure people who buy it know that all of their hair will fall out and they will have large red scabs all over their scalp... for up to 6+ months... that should probably be on the package....
Hair hair loss is the essential process of regeneration. If you don't accept, don't use it.
I will tell all of the people, may arise from using this product. With nothing hidden.
04-20-2015 07:46 AM
liuxuewu
Quote:
Originally Posted by Seuxin
liuxuewu,
It's simple. We know here you was the man who provide the Chlorine dioxyde solution there is a few month.
We didn't see any good resultst...
So, please explains here what is the difference with that new product ( if there is really differences).
Thanks
Most people don't, feedback messages, you call without seeing good results can only be got incorrect information from individuals.
04-20-2015 07:49 AM
liuxuewu
Quote:
Originally Posted by Conpecia
there has been ample time for the many people who have tried this product to come forward with results. none of them has done so. not one. liu, no one should give you money or time until you return with clear photographs showing results. by now you should have 50-100 people showing results and there is nothing. why?
Do you use finasteride, Mi Nuodi son, did you ever see good results?
My purpose of this chip is to United States application for clinical trials, it will have good results.
Before trial, a lot of people just didn't give me feedback.
04-20-2015 07:57 AM
liuxuewu
Quote:
Originally Posted by Terry Mancini
Liu, come on mate?
If your product was any good you would have convinced some geezer or big business with plenty of readies to form a joint venture.
No doubt you would be wearing £10,000 suits and crocodile skin shoes for your weekly apppearance on talk shows were you would be laughing at Robert De Neros jokes, though you aint got a clue what hes really saying
We want genuine scientific evidence, not your hear say or some picture of you on the front of Time magazine sandwiched between two beautiful women who are six inches taller than you.
It is not a drug, I can't give you proof. So I'm going to the United States FAD applications for clinical trials, if finished the clinical trials naturally have evidence.
Even if you use and no amount of finasteride and miner, and nor can you regrow hair, so if you are bald now, so you'll always be bald.
04-20-2015 07:59 AM
liuxuewu
Quote:
Originally Posted by noisette
Not, I don't want to put your product on my head, my scalp when I saw the testers heads lol.
Please, feel free to show us your results.
