JAK Inhibitors and Hair Loss - Dr. Angela Christiano Interview

Pharmacologic inhibition of JAK-STAT Signaling Promotes Hair Growth

Spencer Kobren speaks with Angela M. Christiano, PhD about her team’s game changing findings that FDA approved JAK inhibitor drugs induce rapid and robust hair growth when applied topically in both mice and humans. Could JAK inhibitor drugs finally lead to a universally effective treatment for both alopecia areata and common male pattern baldness? It certainly looks promising, and the research community is extremely excited about it.

What can I say? You are the man Spencer! This is very exciting indeed. I hope nothing gets derailed and some big pharma company comes to the plate.

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Originally Posted by tbtadmin

Pharmacologic inhibition of JAK-STAT Signaling Promotes Hair Growth

Spencer Kobren speaks with Angela M. Christiano, PhD about her team’s game changing findings that FDA approved JAK inhibitor drugs induce rapid and robust hair growth when applied topically in both mice and humans. Could JAK inhibitor drugs finally lead to a universally effective treatment for both alopecia areata and common male pattern baldness? It certainly looks promising, and the research community is extremely excited about it.

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It's always so much more exciting to hear the "inside baseball" stuff that the media never gives us. This is a really great interview! Let's hope a couple of enterprising doctors start offering some small off lable trials to people who can afford it. I would give it a shot especially since Dr. Christiano said that there will be a very small chance of side effects. Seems like this can really be a great treatment!

So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




(sorry, had to get this off my chest)

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Originally Posted by Link Mahboi

So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




(sorry, had to get this off my chest)

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Histogen undeniably works and the necessary trials will be completed in an acceptable timeframe. And it will cost only a fraction of a transplant. And bimatoprost works. And SM04554 seems to work. And Replicel/Shiseido claim a working product and have specified a not-too-distant release date too. Not sure why these facts haven't really been recognised yet but that's what they are. And these things also make transplants a viable option since requiring repeated operations and possibly running out of donor hair won't be an issue. The topic of this video is old news too, it was announced ages ago.

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Originally Posted by Link Mahboi

So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




(sorry, had to get this off my chest)

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I haven't listened to the interview yet. Why? Does she state this will not work for MPB?

3 to 5 years...again

too late for many

Relax people.

Very interesting interview, thank you Spencer.

she was really beating around the bush when it came to answering that question. she did not want to give a definitive answer, although for some reason I think she knows. my guess, and this is my guess only, is that she is trying to prolong this as much as she can to get research money over the next five to ten years. as far as I know she doesn't own the rights to these drugs and wouldn't make any money if this is a cure or a fix. she's only getting money as a researcher, correct? if that's the case then the only way she makes money is by constantly researching.

again to me it seems like these rare problems (AA, vitiligo) are what's being addressed but it hits a small percentage of the population. These findings keep everyone interested about the drugs potential but MPB is not being touched. that's because MPB the big payday right and once that solved they are out of a job

there has been no information as to what concentration would work in a topical right? I would really love to ask my dermatologist to have this compounded but I have no idea what percentage to use

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Originally Posted by Link Mahboi

So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




(sorry, had to get this off my chest)

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Her lab is testing now for AGA. What part of that did you not hear? She's being realistic, but these drugs are the only safe drugs known to man that convert telogen hair into anagen hair and does it rapidly. It's a big deal for both AA and AGA.

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Originally Posted by jjo

3 to 5 years...again

too late for many

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Or none if you're on fin...if you're one if those people debating it, only old balding men who are bitter spread the fact it kills dick lol.

ShookOnes, plenty of relatively young guys like me tried fin when they still had a good head of hair.
No one's saying it's not worth giving it a shot, but claiming fin doesn't and can't possibly cause severe side effects in some perfectly healthy people is complete idiotism. Take your twattery elsewhere.

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Originally Posted by PayDay

Her lab is testing now for AGA. What part of that did you not hear? She's being realistic, but these drugs are the only safe drugs known to man that convert telogen hair into anagen hair and does it rapidly. It's a big deal for both AA and AGA.

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I listened to the interview and did not hear her say anything about her lab now testing for AGA (MPB AND FPB). What I got was her saying she was trying to get pharma to fund trials for AGA.

If they already tested it on people with AA how hard would it be to find 2 peoople even 1 person with MPB to put it on there head and see if it grows hair back. Im sure theres someone with MPB who works in there lab who would be more then happy to give it a try (maybe the janitor). Then they would have there answer and im sure there will being many investors lining up!

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Originally Posted by jjo

3 to 5 years...again

too late for many

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LOL it's 3-5 years for PHASE I, if (and that's a big if) a pharma company decides to investigate this for AGA instead of areata.

These findings don't matter if no companies will trial it.

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Originally Posted by champpy

she was really beating around the bush when it came to answering that question. she did not want to give a definitive answer, although for some reason I think she knows. my guess, and this is my guess only, is that she is trying to prolong this as much as she can to get research money over the next five to ten years. as far as I know she doesn't own the rights to these drugs and wouldn't make any money if this is a cure or a fix. she's only getting money as a researcher, correct? if that's the case then the only way she makes money is by constantly researching.

again to me it seems like these rare problems (AA, vitiligo) are what's being addressed but it hits a small percentage of the population. These findings keep everyone interested about the drugs potential but MPB is not being touched. that's because MPB the big payday right and once that solved they are out of a job

there has been no information as to what concentration would work in a topical right? I would really love to ask my dermatologist to have this compounded but I have no idea what percentage to use

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She answered pretty clearly - there are simply no solid plans to look into its effectiveness for AGA. She said a company would have to decide to invest in testing it for AGA, refining its delivery, etc.

I would have rather heard her opinion on other drugs in testing (especially Samumed's, since I think she has helped with phase II in some sense). This isn't really much of an issue considering it would probably be 10 years to market if they started testing today (unless they can skip phase I due to the amount of data on Jak inhibitors, but it seems they have limited information on topical delivery).

I don't get it. Why can Christiano test this in her lab for areata and not do preliminary studies for AGA? I get that funding a full on clinical trial is more complicated, but they didnt do a clinical trial for areata either, they just went for it. ??? confusing- anyone have any clarity on this? Also, this seems like way more of a no brainer for a pharma to jump on than the PGD2 stuff, the fact that they tested this on DP spheres and it had such a huge impact means that there's no way this doesnt have some positive effect for aga. JAK inhibitors clearly impact the follicle positively either way. Come on drug compaines- get on this!! Makes no sense that pharma wuld fund things like bimatoporst, which has such limited efficacy, and not this. Does anyone know of forum members trialling a JAK inhibitor topically? It didn't seem like christiano was particularly concerned about that, seems the drugs are really pretty safe. If I had the money, I'd do it.

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Originally Posted by sdsurfin

I don't get it. Why can Christiano test this in her lab for areata and not do preliminary studies for AGA? I get that funding a full on clinical trial is more complicated, but they didnt do a clinical trial for areata either, they just went for it. ??? confusing- anyone have any clarity on this? Also, this seems like way more of a no brainer for a pharma to jump on than the PGD2 stuff, the fact that they tested this on DP spheres and it had such a huge impact means that there's no way this doesnt have some positive effect for aga. JAK inhibitors clearly impact the follicle positively either way. Come on drug compaines- get on this!! Makes no sense that pharma wuld fund things like bimatoporst, which has such limited efficacy, and not this. Does anyone know of forum members trialling a JAK inhibitor topically? It didn't seem like christiano was particularly concerned about that, seems the drugs are really pretty safe. If I had the money, I'd do it.

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totally agreed! nothing will come out of it if we don't trial this on our own. we need to get our hands on JAK inhibitors asap! only thing is, we need some professional chemists who are able to create a nice formulation for absorbtion.
this JAK stuff seems promising and we have to wait another 3 to 5 years for first results? screw that! where are the pros of the usual group buys, with chemical know how? we need that stuff on our heads now!

Great interview! What date is this from exactly? I can't find it on the main site.

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Originally Posted by Link Mahboi

So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




(sorry, had to get this off my chest)

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That "slut" is a woman who has lived with AA and dedicated her life and laboratory work to helping people and she has helped millions. She is honest and is doing more than 99.9999 of the labs dedicated to hair loss research. You should watch what you say and show a little respect a** hole.

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Originally Posted by jamesst11

That "slut" is a woman who has lived with AA and dedicated her life and laboratory work to helping people and she has helped millions. She is honest and is doing more than 99.9999 of the labs dedicated to hair loss research. You should watch what you say and show a little respect a** hole.

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I think he was calling nature a slut (not the doctor). PS Im sure if Dr Christiano wanted to know if it worked for AGA she could quite easily find a volunteer with MPB i working in her lab. Then she would have her answer and pharma would be lining up to invest!

:)

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Originally Posted by sdsurfin

I don't get it. Why can Christiano test this in her lab for areata and not do preliminary studies for AGA? I get that funding a full on clinical trial is more complicated, but they didnt do a clinical trial for areata either, they just went for it. ??? confusing- anyone have any clarity on this? Also, this seems like way more of a no brainer for a pharma to jump on than the PGD2 stuff, the fact that they tested this on DP spheres and it had such a huge impact means that there's no way this doesnt have some positive effect for aga. JAK inhibitors clearly impact the follicle positively either way. Come on drug compaines- get on this!! Makes no sense that pharma wuld fund things like bimatoporst, which has such limited efficacy, and not this. Does anyone know of forum members trialling a JAK inhibitor topically? It didn't seem like christiano was particularly concerned about that, seems the drugs are really pretty safe. If I had the money, I'd do it.

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this is also been my point all along. they have tested it on people with AA, vitilgo, people that cannot grow eyebrows and I believe one other skin condition... All without an official clinical trial!

why can't they try it on people with AGA without a trial??

she even said in the interview, it either works or it won't and it won't take a long time to find out. so why not try it on a few people for a month or two, especially when the risk of side effects is solo topically.

screw this I'm making an appointment with my dermatologist next week to see what she thinks about this

just made my appointment for the 28th of December. I'll update you guys on what she says after the appointment

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Originally Posted by jamesst11

That "slut" is a woman who has lived with AA and dedicated her life and laboratory work to helping people and she has helped millions. She is honest and is doing more than 99.9999 of the labs dedicated to hair loss research. You should watch what you say and show a little respect a** hole.

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This.
I'd say this is a bannable offense.

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Originally Posted by tiktok

This.
I'd say this is a bannable offense.

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are you referring to MY post? I am defending her against name calling... I like Dr. Christiano! she's an incredible woman, super intelligent and I love her laugh. Actually I think I might be in love with her! ;)

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Originally Posted by champpy

just made my appointment for the 28th of December. I'll update you guys on what she says after the appointment

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Ask her why she thinks these peeps feel free to test this stuff off-trial all the time for other things but won't test it for AGA.

I'm going to see her because she actually has let me try things off label before. She's the one that gave me the prescription for Dut and Latisse, so fingers crossed she can somehow get this push through

Listen to from 5:37 in the interview she says, "That, again random observation, was sort of what led us to take the hold Jak inhibitor program and move it out of alopecia areata and into normal hair cycling.” What do you think normal hair cycling means? They are testing on AGA and other forms of hair loss too. The thing is, even if the testing is positive they still need backing and she made it apparent that the crazy crowd funding schemes won't really move things along. I thought that was a good point. I think the interview helped to take the whole conspiratorial aspect out of the equation and focused on the reality of how things work. Emailing these researchers and starting crowdfunding campaigns won't do shit. People on these forums can debate about cures all they want or bother these researchers, or send people to conferences, but it won't change a thing. I'm just glad that Spencer has such intimate access to these researchers. Believe me, when the cure is here, he'll know first. You can hear how these researchers react to him that he's deeply in the know and even friends with these people.

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Originally Posted by jamesst11

are you referring to MY post? I am defending her against name calling... I like Dr. Christiano! she's an incredible woman, super intelligent and I love her laugh. Actually I think I might be in love with her! ;)

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I agree with you. She is obviously an extremely intelligent woman and has one hell of a sexy voice and giggle:)

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Originally Posted by PayDay

I agree with you. She is obviously an extremely intelligent woman and has one hell of a sexy voice and giggle:)

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hahaha yes. and IF she brings to market a strong remedy for AGA, then I will propose to her! ;)

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Originally Posted by jamesst11

are you referring to MY post? I am defending her against name calling... I like Dr. Christiano! she's an incredible woman, super intelligent and I love her laugh. Actually I think I might be in love with her! ;)

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No, I was referring to the post you were responding to.

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Originally Posted by champpy

I'm going to see her because she actually has let me try things off label before. She's the one that gave me the prescription for Dut and Latisse, so fingers crossed she can somehow get this push through

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What would she likely prescribe you? Tocabin or whatever it's called?

Watch Spencer Kobren’s in-depth interview with Assistant Professor of Dermatology at Yale University School of Medicine, Dr. Brett King, as he discusses, how with the help of Dr. Angela Christiano’s original groundbreaking research, he reversed the hair loss process in a young man who suffered with alopecia areata for most of his life. This interview was posted earlier this year and illustrates the rate of progress with JAK inhibitors since this interview was conducted. There is no doubt that while researchers remain conservative when it comes to time lines and discussing the effects of JAK inhibitors for the treatment of common male pattern hair loss, significant progress has been made since the interview with Dr. King and there is no doubt that AGA is in their sights.

Ruxo and tofacib are anti-inflammatory drugs is it???aga often has scalp inflammation with hair loss like in my own case.
If so than this can work for aga , what do you think

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Originally Posted by jamesst11

That "slut" is a woman who has lived with AA and dedicated her life and laboratory work to helping people and she has helped millions. She is honest and is doing more than 99.9999 of the labs dedicated to hair loss research. You should watch what you say and show a little respect a** hole.

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Your imbecile, I wasn't calling Dr Christiano a slut, I was calling Mother Nature ! Oh, wait, now I can't call Mother Nature a slut either, even tho she is an unjust, insidious, hierachical bitch? Man you're indeed one very forgiving lad, how can you love Mother Nature after what she has done to you? lol

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Originally Posted by tbtadmin

Watch Spencer Kobren’s in-depth interview with Assistant Professor of Dermatology at Yale University School of Medicine, Dr. Brett King, as he discusses, how with the help of Dr. Angela Christiano’s original groundbreaking research, he reversed the hair loss process in a young man who suffered with alopecia areata for most of his life. This interview was posted earlier this year and illustrates the rate of progress with JAK inhibitors since this interview was conducted. There is no doubt that while researchers remain conservative when it comes to time lines and discussing the effects of JAK inhibitors for the treatment of common male pattern hair loss, significant progress has been made since the interview with Dr. King and there is no doubt that AGA is in their sights.

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Does that mean they are testing them on aga? And if not, then why? I think all of us simply wanted to hear that they would at least test it, and from what Christiano said in that interview, that didn't seem to be the case. She pretty clearly stated that they cannot "repurpose" the drug and do trials. Haven't they already repurposed it for AA?? Why is this all so cryptic? I understand that full clinical trials are expensive and complicated, but the fundamental question remains- why does christiano's lab and brett king's lab feel comfortable rubbing this stuff on someone with AA and not someone with aga? If it's so easy to see whether it works or not, then why not try it? Spencer discourages people from doing this stuff themselves, but in the case of aga, scenarios like this leave people with no other alternative.

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Originally Posted by Link Mahboi

Your imbecile, I wasn't calling Dr Christiano a slut, I was calling Mother Nature ! Oh, wait, now I can't call Mother Nature a slut either, even tho she is an unjust, insidious, hierachical bitch? Man you're indeed one very forgiving lad, how can you love Mother Nature after what she has done to you? lol

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haha... my bad, I didn't properly interpret your post. No worries brother. Mother nature is more than a slut, In the words of Nirvana, "mother nature is a whore". :D

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Originally Posted by jamesst11

haha... my bad, I didn't properly interpret your post. No worries brother. Mother nature is more than a slut, In the words of Nirvana, "mother nature is a whore". :D

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Exactly, thanks for bringing up that quote, I was going to do it soon or later :P

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Originally Posted by sdsurfin

Does that mean they are testing them on aga? And if not, then why? I think all of us simply wanted to hear that they would at least test it, and from what Christiano said in that interview, that didn't seem to be the case. She pretty clearly stated that they cannot "repurpose" the drug and do trials. Haven't they already repurposed it for AA?? Why is this all so cryptic? I understand that full clinical trials are expensive and complicated, but the fundamental question remains- why does christiano's lab and brett king's lab feel comfortable rubbing this stuff on someone with AA and not someone with aga? If it's so easy to see whether it works or not, then why not try it? Spencer discourages people from doing this stuff themselves, but in the case of aga, scenarios like this leave people with no other alternative.

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She said they can’t “repurpose” the drug to administer and distribute to patients like a physician can do in their practice since she is not a medical doctor. Of course they can do it for an AGA trial on a small number of participants. They’ve already done it on mice to see how it works on normal hair cycling. I’m sure they plan on doing the same on humans.

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Originally Posted by sdsurfin

Does that mean they are testing them on aga? And if not, then why? I think all of us simply wanted to hear that they would at least test it, and from what Christiano said in that interview, that didn't seem to be the case. She pretty clearly stated that they cannot "repurpose" the drug and do trials. Haven't they already repurposed it for AA?? Why is this all so cryptic? I understand that full clinical trials are expensive and complicated, but the fundamental question remains- why does christiano's lab and brett king's lab feel comfortable rubbing this stuff on someone with AA and not someone with aga? If it's so easy to see whether it works or not, then why not try it? Spencer discourages people from doing this stuff themselves, but in the case of aga, scenarios like this leave people with no other alternative.

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You hit the nail on the head. It wouldnt be too hard to find a volunteer to see if it actually does anything worth while!

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Originally Posted by Ulti1

What would she likely prescribe you? Tocabin or whatever it's called?

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I have no idea yet. I'm going to print out some of these news articles that point to it being beneficial to hair and see if she'll go for any of it. it's not like I need 30 or 60 pills, just enough to make maybe a 1% solution to test for a month