Started Topical Bicalutamide

Hey, People. Me here (mid 30's Latino mixed, Mexican. Engineer NW1.5 almost 2)

This is some history about my case.

I started a very slow loss of hair since very young, 20y/o or so. Did not really cared at the time since it was not alarming and my dad has a full head of hair, currently he is in his 60's, with minimal thining. However from my mother side all my uncles have some degree of hair loss.

Never investigated nuch at those times since I found ways to cover the receding temples and I started using minoxidil in my mid 20's. Worked wonders to keep my hair and thickening beard, as well as hair all around my body.

That was until around 5 years ago that I got a horrible shedding of 400 hairs if not more daily. I got super scared. Granted at the time I worked graveyard shift, ate like crap and has no excercise, since I am naturally skinny well it did not appear to affect my health (yeah, right). I ran to see a dematologist who prescribed finasteride, cutting 5mg into 4, so I took 1.25mg a day; also to continue on minoxidil and added ketaconazole shampoo.

I kid you not, this stopped my hair loss dramatically. In 2 weeks I had gone from 400 hairs to around 20. I was SO excited! I felt like I had beaten nature, so I went on with my life and improved my health habits. It is worth to mention I had very slight sides that disappeared on 2 weeks whe I started Fin.

Fast forward around 1 year I started noticing again the horrible shedding. WTF was hppening?! I went to the dermatologist and well She said nothing I did not know. I was devastated. I did not want to be bald for a very specific reason; I had an accident when I was a kid that caused a huge scar and deformation on my skull. Otherwise I would be okay with just shaving my head, since my family have ok skulls.

I started investigating more and more. Got to 1.25 twice a day + ketakonazole everyother day + minoxidil twice a day 1ml. No result for one year

Tried 5mg of dutasteride + ketakonazole everyother day + minoxidil twice a day 1ml for 9 months. No result and just slight mental fog as sides. Dutasteride is very expensive to keep.

I swam on medical research. Tried microneedling, and no result, tried topical spironolactone for a couple of months and just got a really nasty smell on my head.

GOD I even thought about reshaping my skull! And since no good FUE transplant surgeons are around my city and I was not going to spend a fortune in a bad surgery.

Then I investigated about 2 Gen antiandrogens and after a lot of research I decided to try Bicalutamide, it seemed pretty safe to use, (take safe with a grain of salt).

Fast forward two months of treatment this is what I have found:

Treatment:
Disolved Bicalutamide in liquid minoxidil 5% to get a dosage of 10mg of Bica and 2 ml of Minox every day.
1.25 Finasteride in the mroning
Ketaconazole shampoo every other day.

Results:
Shedding stopped massively. Hair slowly thickening

Sides:
On the begiginning I got minimal lightheadness that receded in a week or so. Had some problems of very liquid semen, a very minimal decrease of sexdrive. All this is slowly disappearing. No complains from my girfriend, if you know what I mean.


Steps to follow:
Decrease to 8.3 the dosage of Bicalutamide daily and see if improvement continues as expected.

As you can see, this is a constant struggle; however I am hopeful.

Will keep on posting updates.

I have been now in topical bicalutamide for a month and a half:

I reduced the dosis because I started to have sides, It deffinetly stopped my sheding!! I am really excited!

Treatment:
Disolved Bicalutamide in liquid minoxidil 5% to get a dosage of 10mg of Bica and 2 ml of Minox every day.
1.25 Finasteride in the morning
Ketaconazole shampoo every other day.

Results:
Shedding stopped massively. I usually lost around 45 to 70 hairs every time I shuffled my hair, now I juse see a total of 10 or 15.

Sides:
I started problems with erections and saw no difference after a while on the same dosages


Treatment:
Disolved Bicalutamide in liquid minoxidil 5% to get a dosage of 6.5mg of Bica and 2 ml of Minox every day divides in two doses Morning and Night
1.25 Finasteride in the morning every other day
Ketaconazole shampoo every other day.

Results:
Same results. Shedding stopped massively. I usually lost around 45 to 70 hairs every time I shuffled my hair, now I juse see a total of 10 or 15.

Sides:
I stopped having problems with boners and everything appears to be going well

Steps to follow:
Continue with tratment and will continue posting

Hello, that's an interesting treatment/experiment. I am wondering if you can use it every other day since bicalutamide has a good half-life and it's building up systemic. Could you explain a bit further how you dissolve it into Minoxidil? I mean buying Casodex(Bicalutamide) pills, pulverizing them, and throw them inside? Thank you

Yeah, I am now sticking to daily los doses based on the studies to maintain certain level of action on the scalp. Indeed I crush the pills of 50mg of bicalutamide calculating the dosage desired of 6.5 per day.

Thank you very much for your response! I believe that with a bit lower mg dose maybe bica will be good because it's very strong.So, you are pulverizing about 4*50mg Bica pills into 60 ml of Minoxidil?(That makes 0.33% solution=3,3mg/ml) Thank you very much again

I might actually lower the dosage after a month of sticking and reviewing the results. Will keep on posting.

Have you experienced any signs of gyno, i.e. puffy nipples, tenderness in the chest? It's supposed to be one of the most common side effects of bica when taken orally. How long have you been on topical bica and when did you start noticing results?

Asking cause I've been losing ground on oral dut and am interested in trying topical bica too.

Not gyno at all, I take low topical doses to minimize the probability of getting it. I have been on bica for almost two months and a half. I noticed that the shedding stopped on two weeks.

Is Bica a anti androgen in general or does it just combat DHT?

Anti androgen

Have you continued to improve? And can you keep us updated if you start experiencing any sides, i.e. ED, gyno, etc.?

There's at least one study showing that theres 30 percent of ppl who took 10 mg of *oral* bicalutamide got gyno within a 6-9 month period, but it sounds as if the topical formulation might be one way to avoid sides.

I have decreased the intake to let my system un saturate cause I noticed starting to have problems with erections. But no Gyno, nor other sides. After decreasing the dosage I stopped with erectile function but I also noticed shedding increased a bit.

That’s good to hear. Have your hairs thickened or regrown since starting treatment? Are you still above baseline, even with the increased shedding?

Also, are you using any treatments (fin, dut) in addition to topical bica?

Hairs have thicken and got a few new hairs. Sheding is minor than baseline. I am currently taking 1.25 mg of fin everyday + 2 ml of minox + 3 mg of Bica to unsaturate

Hi way back in the late 90s to 2000 you could buy topical Flutamide gel a guy i think in germany got it made and i tried it i did not get any side affects but the company went out of business as you could look up the sintov file on topical flutamide which is the mother of all anti androgen's but there can be side affects that's why sintov made a gel that was safer to use topically.
As to mixing in minoxidil you really need a pure powder that like ru you can mix in pure alcohol as ru i tried mixing in minox and it did not work so i returned to the latter.
I also tried crushing up flutamide and finasteride but even with straining through a funnel with filter there was a gritty minox mess.
Thats why i am buying topical 5% minox with finasteride in it and going back to the topical flutamide gel everyone at that time wanted to get there hands on it or the gel needed to make but could not but one things for sure the sinov trial did regrow male hair.

How might flutamide treat androgenetic alopecia

Flutamide is the generic name for the commercial brand name drugs Euflex and Eulexin by Schering. Flutamide comes as 250mg oral tablets.

Flutamide is a non-steroidal antiandrogen which inhibits androgen uptake. Flutamide also stops androgens from binding to receptors in the nuclei of cells. Flutamide is used to treat a variety of androgen influenced diseases such as prostate carcinomas, hirsutism, acne, and alopecia. As an antiandrogen oral flutamide has been used to treat female androgenetic alopecia, but only one or two published studies on its effectiveness are available. One study involved treating women with hirsutism, acne, or alopecia. The investigators reported an 80% success rate for women with acne of alopecia when treated with flutamide. They reported that Flutamide was significantly superior to Spironolactone for treating androgen dependant conditions in women. There are several studies on the use of flutamide to treat androgen dependent hirsutism in women and all suggest moderate to good success rates.

Another study looked at the efficacy of topically applied flutamide versus finasteride in human bladnig sclpa skin grafted onto mice. The researchers observed that flutamide was better than finasteride in terms of promoting hair growth. From this study it may be possible for men to use topical flutamide and avoid the systemic side effects that men develop when taking the drug orally.

How might flutamide treat androgenetic alopecia references

Luthy I, Caron S, Belanger A, Labrie F. Effects of flutamide, a pure antiandrogen, on endocrine parameters, in the adult female rat. Gynecol Endocrinol. 1987 Jun;1(2):151-68.
Cusan L, Dupont A, Gomez JL, Tremblay RR, Labrie F. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil Steril. 1994 Feb;61(2):281-7.
Sintov A, Serafimovich S, Gilhar A. New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice. Int J Pharm. 2000 Jan 20;194(1):125-34.
Singh SM, Gauthier S, Labrie F. Androgen receptor antagonists (antiandrogens): structure-activity relationships. Curr Med Chem. 2000 Feb;7(2):211-47.
Muderris II, Bayram F, Sahin Y, Kelestimur F, Tutus A, Ayata D. The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism. Fertil Steril. 1996 Aug;66(2):220-2.
Marcondes JA, Minnani SL, Luthold WW, Wajchenberg BL, Samojlik E, Kirschner MA. Treatment of hirsutism in women with flutamide. Fertil Steril. 1992 Mar;57(3):543-7.

There is as we know RU58841 but the only problem with that is none of us can tell if what we buy or even when made its stable there ae no guarantee's that's the most frustrating part as until topical cb-03-01 or Breezula come's onto the market we will see i am not sure if that will be as strong as flutamide but it will have to be safer before it is sold.
There was a guy on the hairloss forums that tried oral flutamide and i think he did grow his hair back but the side affect's were not good he said he felt so weak he had to crawl along to get out of bed as it can damage the liver as well so take that as a warning.

I've started dissolving about 8-10 mg of bica into either stemoxydine or minoxidil every day and applying it to the scalp. It's been about 10 days, but my scalp still itches.

Did you notice a reduction in scalp itch immediately?

Any update? And how long did it take for the scalp itch to disappear? I tried topical bica for a little under 2 weeks but it seemed to increase my itch and even put me slightly below baseline (though that could also have been a coincidental shed from the minox I'm using).

I am posting this as an official end of this trial. Eventhough I have decreased doisis to a point of halting taking it because of ED problems. I have stoped now for 3 weeks and normal erectile function has been restore to normal.

I am happy to answer any questions.

Itching for me has been caused by minox liquid solution. I could eliminate it by washing my hair with Traditional Head and Shoulders everyday.

Quote:

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Originally Posted by Wolfen

I am posting this as an official end of this trial. Eventhough I have decreased doisis to a point of halting taking it because of ED problems. I have stoped now for 3 weeks and normal erectile function has been restore to normal.

I am happy to answer any questions.

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How has your hair been since stopping the bica? What will you do now? I thought you said that neither fin nor dut was working anymore, which is basically my situation.

And you were never below baseline while you were on bica, right?

Yeah, none of it works but ED is something I am not willing to experience in order to stop hair loss. I will continue to tak 1.25 mg of fin and 2 ml of minox a day.

As I mentioned before here, Bicalutamide is very strong and it has such a good half-life, so it can go and build up systemic, easily. That's why I said that maybe cycling the drug with even a lower dose, for example, a dose of 1mg per 2ml, apply 4 days/week, 3 days/week, 2/week days stop 1 week and repeat, it would be beneficial without the risk of side effects. Again, this may be not the case as well, because as I said Bica is a very strong drug, it is just a speculation for a different approach of the drug topically. Thank you for trying this experiment Wolfen, stay safe and keep up the fight!

I do not know if the dosage would be enough to make a difference on hair loss. I might give it a try after a couple of months under the same advice. I will post about it

Quote:

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Originally Posted by Wolfen

I do not know if the dosage would be enough to make a difference on hair loss. I might give it a try after a couple of months under the same advice. I will post about it

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Where did you get your bica, by the way? How did you crush the pills fine enough to dissolve in a vehicle? And did you ever have trouble dissolving in minox (I.e. getting a cloudy solution instead of a clear one)?

I got it in the pharmacy. WHere I live I do not need a perscription for bica. No problem crushing them nor dissolving it you will get a slightly cloudy mix

Quote:

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Originally Posted by Wolfen

Yeah, none of it works but ED is something I am not willing to experience in order to stop hair loss. I will continue to tak 1.25 mg of fin and 2 ml of minox a day.

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Did you try taking an AI while on bica? Your ED might've been a result of high estrogen levels since bica is known to raise them.