This does not in any way exclude DHT from the picture - as hormones are involved in regulating genexpression. It could very well be DHT that regulates PGD2 synthesis in the follicles that are prone to MPB.
03-22-2012 12:51 AM
Mojo Risin
This won't give hair back to a Norwood 7.
Just a minoxidil on steroids.
03-22-2012 03:14 AM
Gubter_87
Mojo: What makes you say that?
Truth is we have no idea what significance this will have today. If the hair follicles are actively inhibited by PGD2, and we are able to inhibit that inhibition - then there is no saying if the hair will grow back or not.
It could give a NW7 a full head of hair, and just as well it could be of minimal significance to hair loss.
There is no logic in comparing this to minoxidil, which stimulated potassium channels. They have nothing in common.
Come on guys, are you really going to fall into Cotsarelis trap again ? Isn't it obvious enough that the guy is just seaking easy fundings ? Seriously we're more intelligent than that, I'm not buying into Cotsarelis BS again. The guy comes out every year or so with a new piece of the puzzle ...
He comes up with a new hypothesis every year or so ... it gets so redundant. I just have no reason to trust this guy honesty anymore.
Couple weeks ago, someone tried to get Cotsarelis in an interview to talk about Follica ... and he refused. And now all of a sudden, he's all over the media. Come on ...
03-22-2012 03:42 AM
Pate
Quote:
Originally Posted by Gubter_87
There is no logic in comparing this to minoxidil, which stimulated potassium channels. They have nothing in common.
Actually they have a lot in common, namely the fact they act on prostaglandins. We know the potassium channels aren't the cause of hair growth in minox because other K channel drugs and other vasodilators have no hair growth effects. It is thought that minox regrows (some) hair because... surprise surprise, it stimulates a certain prostaglandin. Latisse stimulates another one. This discovery is about inhibiting a third.
I think this is fascinating. No immediate joy for hair loss sufferers, even these asthma drugs in Phase III will need to go back through clinical trials for hair loss. The only real benefit is probably that they won't have to do the pre-clinical toxicology research etc, plus there will be less red tape with the FDA.
But Cotsarelis is doing some amazing work. This led directly from his discovery about the inactivated stem cells. They figured something be preventing the activation of the stem cells so they went out and looked for it, and in a pretty short space of time found something.
It just sucks this work isn't likely to lead to viable treatments in time for most of us.
03-22-2012 03:55 AM
Mojo Risin
And aren't you guys tired of seeing every single findings getting reported by media as a POTENTIAL CURE FOR BALDNESS. I mean ... it gets so frustrating. How many times did we read that in the past 10 years ?
03-22-2012 04:14 AM
Pate
Quote:
Originally Posted by Mojo Risin
And aren't you guys tired of seeing every single findings getting reported by media as a POTENTIAL CURE FOR BALDNESS. I mean ... it gets so frustrating. How many times did we read that in the past 10 years ?
Sure. But that's the media's fault, not Cotsarelis's. The media don't give a damn about prostaglandin inhibitors and their effect on GPR44 receptor. All they care about is that they can print POTENTIAL CURE FOR BALDNESS and watch the paper sales and the advertising revenue roll in.
I think you're picking on the wrong target. Before fully effective treatments of hair loss can be developed we need to know the exact mechanisms that cause it. Cotsarelis is working on this and doing some groundbreaking research. And if he can ensure continued funding for his research with the occasional media press release, then I say good on him. I'd much rather that than that his centre goes bust through lack of funds, hair loss research comes to a dead end and Cotsarelis goes off to study the life cycle of earwigs, or something.
03-22-2012 05:28 AM
Thermal
Sodium cromoglycate (SCG) found to inhibit prostaglandin D2 (PGD2)
i think inhibiting pgd2, would yeild really good results at the temples/hairline!
03-22-2012 07:54 AM
UK_
So... After they tested the hair follicle that was immune to the effects of PGD2... was it still affected by DHT?
I can't believe after all this time, this is the best Follica can come out with - I thought back in 2008 they were "just around the corner" lol - another 5 years I take it now? so we're all set for 2017? What happened to the lithium study?
Im guessing Histogen will be releasing some Phase II data at the medical convention this May.
