Morphogenesis involves a complex series of cell signaling, migration and differentiation events that are coordinated as tissues self-assemble during embryonic development. Collective cell movements such as those that occur during morphogenesis have typically been studied in 2D with single layers of cultured cells adhering to rigid substrates such as glass or plastic. In vivo, the intricacies of the 3D microenvironment and complex 3D responses are pivotal in the formation of functional tissues. To study such processes as collective cell movements within 3D multilayered tissues, we developed a microfluidic technique capable of producing complex 3D laminar multicellular structures. We call this technique “3D tissue-etching” because it is analogous to techniques used in the microelectromechanics (MEMS) field where complex 3D structures are built by successively removing material from a monolithic solid through subtractive manufacturing. We use a custom-designed microfluidic control system to deliver a range of tissue etching reagents (detergents, chelators, proteases, etc.) to specific regions of multilayered tissues. These tissues were previously isolated by microsurgical excision from embryos of the African claw-toed frog, Xenopus laevis. The ability to shape the 3D form of multicellular tissues and to control 3D stimulation will have a high impact on tissue engineering and regeneration applications in bioengineering and medicine as well as provide significant improvements in the synthesis of highly complex 3D integrated multicellular biosystems.
The emergence of 3D technology has enabled scientists to mimic the exact cellular environments and helped to provide better insights into the cell signalling, migration and differentiation in cells.
One of the ways of mimicking the cellular architectures is bio-etching which involves subtractive manufacturing. Bioetching of monolayers of cells in response to laser cuts or scratch assays is achieved by using 2D cell culture studies. But the actual biological systems such as tissues and organs are much more complex and cannot be mimicked using simple monolayers. For long time, scientists have been working on developing better technologies to address this problem. One of the ways to achieve this is 3D bio-etching.
William C. Messner et al. from Tufts University in a recent article in Lab on a Chip explain the utility of 3D bioetching technique to create and shape 3D composite tissues using a microfluidics based approach.The ability to shape the 3D form of multicellular tissues and to control 3D stimulation will have a high impact on tissue engineering and regeneration applications in bioengineering and medicine as well as provide significant improvements of highly complex 3D integrated multicellular biosystems."
3D bio-etching hair germs soon in clinical trial, mark my words :D
08-31-2015 05:52 AM
Hairismylife
How soon? 3 years? 10 years?
08-31-2015 06:32 AM
baldybald
Quote:
Originally Posted by Hairismylife
How soon? 3 years? 10 years?
10+ years bro
08-31-2015 06:38 AM
Link Mahboi
Quote:
Originally Posted by Hairismylife
How soon? 3 years? 10 years?
Never, and you know that..
08-31-2015 06:42 AM
lacazette
IMO with this new tissue engineering method and that rate of progress, i think at least one of them will enter trial in 2016: takashi tsuji and riken center, Regience company, sung jan lin from taiwan engineering (who already tested 3D hair on human clinical trial since 2007), sisheido, keio university, protect& gambler collaboration with Singapore multi labs for tissue engineering therapies, theracell, the many chinese affiliated hospitals/universities for tissue engineering, 3D bioprinting solutions from russia, and add a few ones from europe and usa, and all the lab/university/company in the world who work on tissue engineering and aims for clinical trial, it's sounds good
Look at the 3D bioprinting/engineering vitess progress, it's unreal
This kind of method above lowered the timeline, I really think that the 2018 2020 cure is becoming concrete day after day, and that we will be able to travel to japan, taiwan or Singapore to get our 20000 hair germs transplanted! That day will be insane :D
08-31-2015 04:32 PM
joachim
Quote:
Originally Posted by lacazette
IMO with this new tissue engineering method and that rate of progress, i think at least one of them will enter trial in 2016: takashi tsuji and riken center, Regience company, sung jan lin from taiwan engineering (who already tested 3D hair on human clinical trial since 2007), sisheido, keio university, protect& gambler collaboration with Singapore multi labs for tissue engineering therapies, theracell, the many chinese affiliated hospitals/universities for tissue engineering, 3D bioprinting solutions from russia, and add a few ones from europe and usa, and all the lab/university/company in the world who work on tissue engineering and aims for clinical trial, it's sounds good
Look at the 3D bioprinting/engineering vitess progress, it's unreal
This kind of method above lowered the timeline, I really think that the 2018 2020 cure is becoming concrete day after day, and that we will be able to travel to japan, taiwan or Singapore to get our 20000 hair germs transplanted! That day will be insane :D
i have to agree. a new era of modern tissue and organ engineering is happening NOW in front of our eyes and will advance rapidly over the coming years. bio-engineers now have better tools than ever, for building and screening complex tissues.
the main focus is of course not hair-related but skin and organs in general, this is why more and more research labs worldwide are popping up from nowhere as the interest is extremely high. if i were a student in biology or medicine at that time, this is exactly the most interesting field i would like to go to. iPS stem cells, gene editing, and building organs at will is the key to a much longer and disease-free life. it's THE modern medicine of the future and will change mankind forever. of course, researchers want to be part of that evolution.
those breakthroughs will also help engineering perfect lab-grown follicles very soon.
it's even possible that building whole skin patches with hair follicles is easier than creating single follicles. maybe those projects at DARPA or wake forrest will be a possible route.
all in all, lab-grown follicles are happeing within the next 1,2,3, or 4 years or so. if that day comes, we can only hope that trials and bureaucracy aren't holding the cure back. i think we all agree that the cure can only happen in japan within the next years.
Omg Im student of sogang university i'll try to contact the professor
09-01-2015 06:49 AM
allTheGoodNamesAreTaken
Lacazette you are one of the only reasons to bother visiting this site anymore. You seem to be the only one turning up actual cutting edge news these days, the rest is just people whinging that life's not fair and there won't be a new product commercially available in 5 minutes.
09-01-2015 07:56 AM
hellouser
Quote:
Originally Posted by allTheGoodNamesAreTaken
Lacazette you are one of the only reasons to bother visiting this site anymore. You seem to be the only one turning up actual cutting edge news these days, the rest is just people whinging that life's not fair and there won't be a new product commercially available in 5 years.
