Why is Nizoral considered a big three?

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  • oldschoolplaya
    Junior Member
    • Sep 2015
    • 18

    Why is Nizoral considered a big three?

    Has there ever been any any studies done that this shampoo is anything but snake oil? It isn't even marketed for hair loss. Why would a company not market their shampoo for hair loss if it had such amazing results? Everyone uses it as a supplement for the other big 2... Has anyone actually maintained/grown hair using only it?

    Just because someone had good results using the big 3 doesnt prove jack that it had anything to do with nizoral.
  • JohnMPB
    Senior Member
    • Nov 2009
    • 382

    #2
    Google is your friend


    Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase …

    Our understanding of the aetiology of androgenetic alopecia (AGA) has substantially increased in recent years. As a result, several treatment modalities have been tried with promising results especially in early stages of AGA. However, as far as has been ascertained, there is no comprehensive study …

    Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.

    Ketoconazole (KCZ) is an imidazole anti-fungal agent that is also effective in topical applications for treating seborrheic dermatitis and dandruff. Recently, topical use of 2% KCZ shampoo has been reported to have had a clinically therapeutic effect on androgenetic alopecia. The present study was c …

    Hair shedding and hair thinning have been reported to be affected by dandruff and seborrhoeic dermatitis. The present study was conducted in 150 men presenting with telogen effluvium related to androgenic alopecia associated with dandruff. They were randomly allocated to three groups receiving each …

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    • polios
      Member
      • Oct 2015
      • 74

      #3
      It considered to be part of the big 3 because it is actually some medical treatment and not some herbal mixture of something. The results are well documented and the studies on the active ingredient ketoconazole are not only done by the company selling the product.

      Using it as a hair loss shampoo is considered an off-label use. However, there all other hair loss medicine was also developed for other reasons and the anti-hair loss effect was only a side effect of most of them.

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      • warner8
        Senior Member
        • Jan 2015
        • 352

        #4
        kept is supposed to have anti-dat properties and anti inflammatory properties in the scalp. obvious the anti dht is not anywhere as strong as fin or cut, but it might be worthwhile adding to your regimen if you have the extra cash, i use regenepure dr.

        Originally posted by oldschoolplaya
        Has there ever been any any studies done that this shampoo is anything but snake oil? It isn't even marketed for hair loss. Why would a company not market their shampoo for hair loss if it had such amazing results? Everyone uses it as a supplement for the other big 2... Has anyone actually maintained/grown hair using only it?

        Just because someone had good results using the big 3 doesnt prove jack that it had anything to do with nizoral.

        Comment

        • JohnMPB
          Senior Member
          • Nov 2009
          • 382

          #5
          Originally posted by Rashid Rashid, MD, PhD
          It is great to see people using pubmed/medline and ncbi. Rather then be pushed around by marketing hype, its good to focus on the evidence. Sure things like PRP and Acell may one day be proven effective, but why spend the money and take the chance before that time?
          Dr. Rashid, what is your opinion on dutasteride in regards to treating mpb? I've been waiting for long term studies to be released but I doubt that will never happen. Given the fact that generic avodart has been released the last few months I doubt this will ever happen.

          Comment

          • mark8
            Member
            • Oct 2015
            • 54

            #6
            Originally posted by Rashid Rashid, MD, PhD
            It is great to see people using pubmed/medline and ncbi. Rather then be pushed around by marketing hype, its good to focus on the evidence. Sure things like PRP and Acell may one day be proven effective, but why spend the money and take the chance before that time?
            But of course people finding a few abstracts on the internet and deciding what course of action is best is also not a good idea. One can find a study supporting just about any point of view, this is why one needs to talk to an experienced and competent doctor before medicating oneself. There are lots of expert, very experienced doctors who say Nizoral by no means should be considered part of a "big three" with finasteride and minoxidil, as it's either much much less effective, or completely ineffective for helping with hair loss. What's your opinion about this? Have you had patients who have significantly regrown hair using only Nizoral? Many, few? None? There are a lot of responses here, like google is your friend, and it's great to see people using google to find abstracts, which don't address the central question in the OP.

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