For those who are desperate to buy CB (I am), we all need to find a way to get Versapro. I figured I'd make this thread so people could throw up potential ideas. Or if anyone has a way to get it and could help us out, that would be amazing. I'm ready to order CB from Kane, but can't figure out how to get this Versapro vehicle.
Versapro: How can we all get it?
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Hey guys,
There is nothing wrong with the current vehicles to deliver drugs under 550mol into the dermal papilla compartment. Ethanol vehicles are proven delivery methods, and great penetration enhancers. what do you think that makes CB so special that it needs a other type vehicle? the molecules can easily penetrate through the hair root with the current proven vehicles.
some people even dared to rumor that it had to do with the crystalline form.. and made a hype that you needed the cosmo cream for cb to work, however when a chemical is dissolved, it will be not in crystal form... this is basic chemistry. that was the second time that people went into the hype/ cb boat. Again allot money and time wasted there. they did 3-4 group buys in the past, and the cb was always 3d party tested.
The problem is the dose/ efficiency on the androgen receptor.
here is a quote from swooping where he explains cb's effectiveness in relation with cyproterone acetate.
Fcking no hell lol broscience, we wish it was like that. Evidence atm points out it is less potent than RU-58841. You refer to this study; http://www.ncbi.nlm.nih.gov/pubmed/15646372
This is from the study, now note cyproterone acetate is just a little bit more active than cb-03-01 in the hamster flank organ test. I have a study about RU-58841 on hamster flank organ test also I'll dig it up later if you are interested but I'm sure it was more potent than these figures. Secondly the following is a statement about RU58841;
Meaning RU-58841 is likely stronger than than cyproterone acetate and thus likely stronger than CB-03-01.
Also be aware that the cb-03-01 comparison to finasteride in this test is hilarious. They are comparing a 5ar2 inhibitor with a anti-androgen. This obviously will say nothing about it translating for AGA, keep that in mind.
Now guys, think about it. Why was the vehicle ever a problem? Wouldn't it be logical for it that we need a higher concentration for it being effective?
If RU-58841 and cyproterone acetate outperform cb-03-01 then why would cb-03-01 work at a dosage of 1-2%, do you see RU-58841 or cyproterone acetate working that good at such a dosage? I don't think so.
That is what the problem ever was, cosmo just released a new patent in 2014, where they also state the pharmaceutical composition of the cream, and it is nothing special.
The vehicle was never a problem, the concentration was. If you think otherwise come up with reasoning, or I would like to hear it from desmond. I have spoken to chemists and there is literally no reason to think the vehicle was a problem ever.
And yes 5% is going to be expensive as hell I guess.
the efficiency at the same dose as ru is likely less potent, however lets assume for a minute that it is the same, the price is very high, and the risk for importing a patented steroid-structure makes it hard.Comment
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And it is suposed to be sidefree as advertised , but that seems not the case in the groupbuy trials.
About 6-7 reported chest pains and other sides.
Copy paste from other forum :
Reported side effects from the 1% cream
Throat discomfort, headache, chest pain and aching testicles decreased vision, sexual sides, brainfog.Comment
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damn! so the conclusion is we should forget about CB. one of the most promising treatments within the next years just turned out to be totally useless. all the hype for nothing.
remaining hopes is only replicel. histogen seems to be dead, and team lauster doesn't even manage to put the new info website online as they claimed.Comment
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CB is totally useless? They need to find the right concentrations for it work for MPB thats all. It might work really well and still be safe at high doses. Again no one knows until they figure outComment
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Pure desperateness and 3 years ago the most of us in the community where not capeble of interpreting research studies. So yeah easy to buy into some hypes.
And it is suposed to be sidefree as advertised , but that seems not the case in the groupbuy trials.
About 6-7 reported chest pains and other sides.
Copy paste from other forum :
I suppose that even Desmond never pointed sides from CB considering his researches.Comment
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I haven't been able to find anything about how often to apply or concentration that you guys are talking about. Some sources would be nice. Has anyone started yet? Before we scrap an idea that has been talked about at least since late 2011, don't you guys think we should try it? I'll be using at 2% concentration. Hopefully some people will use it at 5%. We'll see what happens.Comment
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damn! so the conclusion is we should forget about CB. one of the most promising treatments within the next years just turned out to be totally useless. all the hype for nothing.
remaining hopes is only replicel. histogen seems to be dead, and team lauster doesn't even manage to put the new info website online as they claimed.
Just because some guy interprets one clinical trial for you in a negative way doesn't mean shit. Cosmo obviously saw potential in developing this drug, and is continuing to test it, which means that NOBODY knows how good or bad it will be. Nobody knows what side effects it will have (every drug has sides. period. sometimes they are mild enough to ignore, and hopefully that is the case for CB for most people. Im sure some people won't be able to take it). I also doubt that the vehicle was an issue, but we also don't know if people were maintaining their hair on it and just gave up due to price, wrong form of the molecule, sides, etc. Also, most of the people on here seem to be people that are especially prone to sides/hypochondria/anxiety etc, and just cause a few dudes say they got heart palpitations or a headache doesn't mean shit. You can get those from anything, including maybe whatever vehicle they were using.
Seeing as CB is just an anti androgen, and has been used to some extent by forum people, I doubt it's a wonder drug. However, I also am sure that if it gets passed, it will have some positive effect on hair loss. the only way to know is to wait and see. Best case scenario, its a good alternative to propecia, though personally I'd rather shave my head than be applying shit to it topically every day. Just isn't really worth it to me. Something like replicel is much more promising, as you don't have to invest your dignity every day into a losing battle, and cells from the back of your head are gonna keep multiplying and growing, so hopefully it proves to be at least a semi-permanent way to fight this thing.Comment
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Also a lot of the people on this forum are young guys with severely aggressive hair loss. You can't base the general effectiveness of a drug based on the worst case patients. For those of us with slow loss, something like CB could make a big difference. I even know guys who maintained on romaine for many years. And for those with aggressive loss, I would have thrown in the towel a long time ago- nothing is gonna halt that kind of balding if propecia doesn't, might as well just live and someday they will be able to create brand new follicles. propecia stops loss for 80 or 90 percent of men, so if it doesn't work for you then shit, why even bother worrying about CB etc. the mechanisms aren't that different.Comment
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