Bulge Cells!!!!

**Henkeh91** · 04-26-2013, 02:30 AM

Originally posted by Kiwi

What do you guys think?

If they can work out how to activate these stem cells we might be getting fixed up sooner rather then later?

http://www.baldingblog.com/2013/04/2...hair-follicle/

Great finding Kiwi! Stem cells seems to be the answer, hopefully they can crack the code soon!

**LongWayHome** · 04-26-2013, 07:08 AM

I'm telling you, soon there's gonne be for sure something big that will change everything.
Everyone is such in a rush to find something, and it definitely wasn't like that in the past.

**youngin** · 04-26-2013, 07:52 AM

This was already posted and ignored. It doesn't seem like that great of a find to me. Studies show that there's genetic damage to the dermal papilla in balding hair. Don't see how this will fix that genetic damage.

**534623** · 04-26-2013, 08:41 AM

Originally posted by youngin

Studies show that there's genetic damage to the dermal papilla in balding hair.

I would like to read one of these studies - at least one.

**youngin** · 04-26-2013, 08:44 AM

Originally posted by 534623

I would like to read one of these studies - at least one.

I don't know if you are being your usual sarcastic self or not, but here you go: http://www.nature.com/jid/journal/v1.../5701147a.html

**534623** · 04-26-2013, 08:57 AM

Originally posted by youngin

I don't know if you are being your usual sarcastic self or not, but here you go: http://www.nature.com/jid/journal/v1.../5701147a.html

First of all, I do not read any studies as soon as one of the Farjo's are involved - because they know a shit about hair follicle biology.
Second, I also do not read any studies who start with the completely wrong information - like this ...

"Androgenetic alopecia (AGA), a hereditary disorder that involves the progressive thinning of hair in a defined pattern, is driven by androgens. The hair follicle dermal papilla (DP) expresses androgen receptors (AR) and plays an important role in the control of normal hair growth."

The dermal papilla doesn't play ANY role "in the control of normal hair growth".

The dermal papilla does only -and that's what this thread is all about- what 1) the bulge stem cells and especially 2) the bulge stem cells microenvironment is telling them what to do. If the tell them, for example, "GAME OVER" - they simply understand this signal FROM THE STEM CELLS' MICROENVIRONMENT as "game over". The dermal papilla is just a "slave" (not the "master") in this whole game. This has something to do with the ORIGINS of the DP.

**youngin** · 04-26-2013, 09:01 AM

You are a ****ing moron. The DP is the controller of all hair growth. Length, texture, curl, everything. The studies on DP's are numerous. You are such a tool. Not even worth debating with. Good luck on your "I know more than everyone" journey.

**534623** · 04-26-2013, 09:18 AM

Prove this ...

Originally posted by youngin

You are a ****ing moron.

... and prove that:

Originally posted by youngin

The DP is the controller of all hair growth. Length, texture, curl, everything. The studies on DP's are numerous.

... and then we will see who is the "****ing moron".

**youngin** · 04-26-2013, 09:30 AM

I'm sick of proving shit to people like you. Do your own damn research. The paper I just provided you showed obvious differentiation between the dermal papillas in bald and non-bald scalp. GET IT?? THE BALD DP WAS DAMAGED AND THE STEM CELLS DID NOT RE-CREATE AN UN-DAMAGED ONE AT ANY POINT. Stimulating the stem cells will probably do nothing! There's multiple studies comparing beard DP's to hair DP's and profiling of both. You are just a troll to this community. Why don't you try and be constructive and go look some shit up for yourself. The fact that DP's control hair length/texture/etc is not some hidden fact.

**534623** · 04-26-2013, 10:27 AM

Originally posted by youngin

I'm sick of proving shit to people like you.

Okay - then for all the other guys. I swear, I will not read your proofs!

**hellouser** · 04-26-2013, 11:02 AM

Originally posted by youngin

I'm sick of proving shit to people like you. Do your own damn research. The paper I just provided you showed obvious differentiation between the dermal papillas in bald and non-bald scalp. GET IT?? THE BALD DP WAS DAMAGED AND THE STEM CELLS DID NOT RE-CREATE AN UN-DAMAGED ONE AT ANY POINT. Stimulating the stem cells will probably do nothing! There's multiple studies comparing beard DP's to hair DP's and profiling of both. You are just a troll to this community. Why don't you try and be constructive and go look some shit up for yourself. The fact that DP's control hair length/texture/etc is not some hidden fact.

Are you suggesting Replicel is pretty much a write-off?

**UK_** · 04-26-2013, 11:12 AM

Sorry but I think Iron_Man is right here - if you look into the work of Jerry Cooley and plucked hair follicles the dermal papilla only respond well when they are transplanted into areas of thinning hair and not slick bald regions. This is (according to Cooley) because the stem cells in thinning regions are still actively sending out some 'growth' signals to the DP, when in slick bald regions there are no 'masters' so to speak or they have become entirely deactivated.

The stem cells are key to it all, I personally believe that Costeralis was right in that slick bald regions do have deactivated stem cells (you cant really refute those biopsies he took) however I do still believe in the theory of a point of no return after a very long time after going bald.

**youngin** · 04-26-2013, 11:20 AM

Originally posted by hellouser

Are you suggesting Replicel is pretty much a write-off?

Replicel uses DERMAL SHEATH CUP cells. So no, I was not suggesting that. Though in my opinion Aderans has a better shot of working since it uses dermal papilla cells. I think either of those COULD migrate to existing dermal cells and be of help.

**youngin** · 04-26-2013, 11:29 AM

Originally posted by UK_

Sorry but I think Iron_Man is right here - if you look into the work of Jerry Cooley and plucked hair follicles the dermal papilla only respond well when they are transplanted into areas of thinning hair and not slick bald regions. This is (according to Cooley) because the stem cells in thinning regions are still actively sending out some 'growth' signals to the DP, when in slick bald regions there are no 'masters' so to speak or they have become entirely deactivated.

Did Jerry Cooley publish this? The ACELL guy, really? I am not even going to acknowledge his work. I never said I don't believe stem cells generate the dermal papilla. I absolutely do. I just don't think the regenerate it often, and I have seen no proof to say that "boosting" stem cells will regenerate the DP and CHANGE the damaged DNA (as noted by the study).

Iron_Man's dumbassery is in the fact that he nitpicks about shit to make himself feel like hes the best. By saying this:

"and plays an important role in the control of normal hair growth." The dermal papilla doesn't play ANY role "in the control of normal hair growth".

..proves his idiocracy. OF COURSE IT PLAYS A SIGNIFICANT ROLE. Ofcourse the stem cells play a significant role also! I just don't think BOOSTING them will change the damaged DNA.

Bulge Cells!!!!

Bulge Cells!!!!

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