Histogen news

[35YrsAfter]

The image below illustrates the problem I have with the Histogen photographic evidence. I downloaded a copy of "Embryonic-like cell-secreted proteins induce hair growth
in a phase I/II trial in male pattern baldness" *.pdf from the Histogen Website. A convincing side by side comparison should of course always be from the same region of scalp. I brought the images into PhotoShop and created a new transparent layer over the top of the image on the left. Next I placed green, 3 pixel dots over the hair shafts at the point they exit the scalp. Next I created a purple circle over the red dye originally on their photo. I used the duplicate layer function and created an exact copy of the transparent dot layer. Next, I moved the dot layer using the shift key (to preserve alignment) from over the top of the left (baseline) image to over the top of the (right) 3 month result photo aligning the purple circle over the red dye dot. The dots as you can see, don't align with the hair shafts emerging from the scalp. Note the hair direction is different as well!!! To be fair, I rotated the image on the right to simulate the baseline hair direction under the transparent layer. I used the "Again" command to rotate the transparent green dot layer into the exact position of the rotated scalp image below. I was still unable to align the dots in any reasonable way. I even tried moving the dot layer around every which way to see if there was any pattern of alignment to be found. There was not. One would think in a fair before and after comparison photo, a dye spot on the "before" image, would indicate the identical region of scalp on the "after" image. In other words, what good is a comparison between two different regions of scalp? Hair density and caliber would of course be different from region to region.



35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
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[hellouser]

I also got the same message a year ago.. it means they're not moving forward...

Yup, just like I said; take it with a grain of salt. It's just a typical corporate answer. They'd give the same response even if they we're about to launch the product today.

[Scientalk56]

Email from Histogen from a few days ago ...

Thank you for your interest and message. In response to your inquiry, development of HSC is continuing. Histogen is currently focused on completion of preclinical and development work that will allow HSC to move into the next stage of clinical trials. In addition, the Company is raising a Series B financing round to support the further development of HSC and Histogen’s other therapeutic programs.

Although Histogen is not currently sharing estimated timelines for market introduction of HSC, I can say that at least one additional clinical trial will be required in any country where HSC will be introduced. The two completed trials were 2 years and 1 year in length, to give you an idea of trial duration. The initial regions of focus for HSC development continue to be the US and Asia.

If you would like to be added to the HSC interest list, for updates on the trials and plans for subject recruiting, please just let us know. We look forward to sharing updates soon.

I also got the same message a year ago.. it means they're not moving forward...

[hellouser]

We should crowd fund this, or have spencer talk to investors. He said on his show a month ago getting millions for a great treatment wouldn't be hard for him to do if he made a few calls...so why not for histogen? they don't even need that much funding.

Sure.... but do we get some kind of early treatment ourselves?

[FearTheLoss]

We should crowd fund this, or have spencer talk to investors. He said on his show a month ago getting millions for a great treatment wouldn't be hard for him to do if he made a few calls...so why not for histogen? they don't even need that much funding.

[hellouser]

That Histogen hasn't officially started the next trial yet is not a good sign. The results they shared with us a while back, while not amazing, at least showed some regrowth. One of the female trial subjects even seemed to have some decent growth in her temples. I have to wonder if potential investors have seen something from the company that is giving them pause.

The investors are clearly stupid seeing how they don't realize how desperate so many of us are for a treatment.

[rdawg]

Email from Histogen from a few days ago ...

Thank you for your interest and message. In response to your inquiry, development of HSC is continuing. Histogen is currently focused on completion of preclinical and development work that will allow HSC to move into the next stage of clinical trials. In addition, the Company is raising a Series B financing round to support the further development of HSC and Histogen’s other therapeutic programs.

Although Histogen is not currently sharing estimated timelines for market introduction of HSC, I can say that at least one additional clinical trial will be required in any country where HSC will be introduced. The two completed trials were 2 years and 1 year in length, to give you an idea of trial duration. The initial regions of focus for HSC development continue to be the US and Asia.

If you would like to be added to the HSC interest list, for updates on the trials and plans for subject recruiting, please just let us know. We look forward to sharing updates soon.

This is basically the same thing they said a year and a half ago.

The message here is they cant get funding, they're just stuck in limbo with the product trying to get someone to give them money to continue. Could take a month could take more years.

makes me mad too, they would've been nearing phase IIb completion by now if they started very soon after the last one, waste of time here

[Thinning@30]

That Histogen hasn't officially started the next trial yet is not a good sign. The results they shared with us a while back, while not amazing, at least showed some regrowth. One of the female trial subjects even seemed to have some decent growth in her temples. I have to wonder if potential investors have seen something from the company that is giving them pause.

[hellouser]

Email from Histogen from a few days ago ...

Thank you for your interest and message. In response to your inquiry, development of HSC is continuing. Histogen is currently focused on completion of preclinical and development work that will allow HSC to move into the next stage of clinical trials. In addition, the Company is raising a Series B financing round to support the further development of HSC and Histogen’s other therapeutic programs.

Although Histogen is not currently sharing estimated timelines for market introduction of HSC, I can say that at least one additional clinical trial will be required in any country where HSC will be introduced. The two completed trials were 2 years and 1 year in length, to give you an idea of trial duration. The initial regions of focus for HSC development continue to be the US and Asia.

If you would like to be added to the HSC interest list, for updates on the trials and plans for subject recruiting, please just let us know. We look forward to sharing updates soon.

Take the email with a very fine grain of salt.

[jpm14]

Email from Histogen from a few days ago ...

Thank you for your interest and message. In response to your inquiry, development of HSC is continuing. Histogen is currently focused on completion of preclinical and development work that will allow HSC to move into the next stage of clinical trials. In addition, the Company is raising a Series B financing round to support the further development of HSC and Histogen’s other therapeutic programs.

Although Histogen is not currently sharing estimated timelines for market introduction of HSC, I can say that at least one additional clinical trial will be required in any country where HSC will be introduced. The two completed trials were 2 years and 1 year in length, to give you an idea of trial duration. The initial regions of focus for HSC development continue to be the US and Asia.

If you would like to be added to the HSC interest list, for updates on the trials and plans for subject recruiting, please just let us know. We look forward to sharing updates soon.

[hgs1989]

Exactly, one trial away from a release..so why no investors? why have they not started this clinical trial? as they have finished over a year ago now with 2a. It can't be that much money they need right? maybe a couple million? and if this is released I can guarantee they will be making more than a couple million. If I had the couple million, I would throw it their way for sure.

how do you know there is no investor? maybe they are trying to figure out the maximum no side effects dosing and testing on animals, maybe they want to move slowly to progress in other directions , maybe they are done , maybe , maybe. WE Don't KNOW.

[FearTheLoss]

the acquisitions made by histogen recently only shows how strong financially they are. the results they have show will attract investors; unless there are complications and serious side effects of their product. once they tell us that they are done, we can say they are; and we will be wondering why. I said that about follica and now we know for sure that they are not successful with their methods and they need money, basically useless for us. we are one clinical trial away from a release.

Exactly, one trial away from a release..so why no investors? why have they not started this clinical trial? as they have finished over a year ago now with 2a. It can't be that much money they need right? maybe a couple million? and if this is released I can guarantee they will be making more than a couple million. If I had the couple million, I would throw it their way for sure.

[hgs1989]

the acquisitions made by histogen recently only shows how strong financially they are. the results they have show will attract investors; unless there are complications and serious side effects of their product. once they tell us that they are done, we can say they are; and we will be wondering why. I said that about follica and now we know for sure that they are not successful with their methods and they need money, basically useless for us. we are one clinical trial away from a release.

[FearTheLoss]

has anyone had any contact with histogen? I don't understand how they wouldn't be able to get an investor when their results were clearly superior to fin/minox and it's an injectable treatment, so it would only have to be done every few years...i mean COME ON...they had results still improving TWO YEARS AFTER the treatment.


I hate to say it, but histogen is dead..sad to see them go as I would have paid thousands for their treatment as is.

[Scientalk56]

Histogen is DEAD...