Spencer Kobren Speaks With RepliCel Life Sciences' CEO and President David Hall

[RichardDawkins]

Hey pennystock, could it be that ou are the banned ironMan? you use his pictures :-) clever

[Penny Stock]

Uploaded with ImageShack.us

My assumption is that Histogen is presenting Regenica to HT docs at the ISHRS Annual Scientific Meeting in Alaska, as a healing aid.

"Embryonic secreted proteins enhance follicular unit viability, and improve donor site healing."

http://www.histogenaesthetics.com/

While updating on HSC trials.


As they have remove Regenica from the market, and changed there business stratagy. The web site has been updated.

This is only my assumption, but I believe it has a solid grounding.

[Penny Stock]

So, are we all jumping from the Histogen bandwagon onto the RepliCel, now?

Hey Man,

By no means was I suggesting to "Jump Bandwagons".

There seems to be a common misconception on this forum, that the race for a cure is a first past the post race.

This is by no means the case, I will explain when I get a few moments.

There also seem to be the misconception that there are only four companies
working on a cure... there are numerous privately funded company’s, who are aiming for the same goal.

One Example:

Celtigen Therapeutics, LLC.

Celtigen is a biotechnology company focused on commercializing its autologous adult dermal stem cell technology for hair follicle regeneration and skin tissue engineering.

http://www.stemcellsummit.com/agenda.html

The basis of every argument against a cure arriving in the near future,
seems to ground itself on the demise of one biotech company.


People get nervous when Histogen changes its site, and removes a time line.

But don't bother to look deeper.

http://www.histogenaesthetics.com/

I don't have much time as I'm at work, but I'm sure you can connect the dots.

We are nearing a tipping point with regards to stem cell research, as a whole.
This is an exciting time in human history, a Baldness cure, a cure for cancer, transplanted organs that don't reject, all on the horizon.

Have a good day Mate.

[HairTalk]

That makes zero sense. Histogen are talking 2015 and they are already well into phase II trials and they are talking 2015 release.

There is no way they can do 2015 unless im missing something.

We have no idea where Histogen is in terms of their clinical trials on H.S.C.; it's possible they're no farther ahead than RepliCel (they might even be behind). The company began phase "I/II" testing, mid-2011; we don't know whether all their subjects have yet been recruited, let alone injected. According to the president of RepliCel, that company has (Sept., '11) completed injections on their last subject.

This said, it's true RepliCel's current work includes 19 participants, whereas Histogen's has aimed for, I believe, 50 or 100.

The bottom line, I think, is, at the moment (Sept., 2011), the earliest by when we might have a new treatment, from anyone, is mid-2015. The only thing I feel could happen sooner, is work involving ACell and/or multiplication-by-transection: perhaps we'll have some sense of these matters by mid-2012 (from Drs. Bernstein or Cooley — I'm not very interested in what words Hitzig or Gho might wish to contribute).

[HairTalk]

Why is there such a gap between phase 1 completion and phase 2 beginning in your timeline hairtalk?

It's just by what's said in the interview with the president of RepliCel, posted in this thread (first post).

[uninformed]

That makes zero sense. Histogen are talking 2015 and they are already well into phase II trials and they are talking 2015 release.

There is no way they can do 2015 unless im missing something.

Also wasn't it nice how histogen were actually in here answering question until dorkins scared them away.

correct me if i am wrong but I think it may have something to do with replicel being the patient's own cells whereas histogen is external growth factors

[PinotQ]

Good Summary Penny Stock. I would add also that my understanding regarding cell culturing, whether it be DP or DSC cells, is that one of the key issues involves being able to culture or multiply the cells in such a way that they do not lose their identity or potency. I don't have any links but I recall that in the early going, those trying to culture cells found out that the longer they were in culture, the more they tended to lose their identity and/or that the new cells being created started to take on irregular shapes. I don't know the actual cell counts or division ratios but for example when 1000 cells divided into 5,000 cells and then 5,000 cells divided into 20,000 cells, then 20,000 cells divided into 100,000 cells, etc........ the new cells were fine. But I believe at about the 5th or 6th division, the process started to breakdown. It may be that Replicel has found a way to solve this problem. It may also be that that is why Replicel can culture for 3 months as opposed to 6-8 weeks but this is all just speculation. I have been under the assumption that solving this issue was one of the big reasons that it has taken so long to get to this point.

[Kiwi]

RepliCel:

~March, 2012: Phase I of testing complete; results available.

~Early 2014: Phase II begins: 3 mos. to enroll pts.; 3 mos. to replicate/inject cells; 6 mos. till follow-up.

2015: release, if all goes well.

That makes zero sense. Histogen are talking 2015 and they are already well into phase II trials and they are talking 2015 release.

There is no way they can do 2015 unless im missing something.

Also wasn't it nice how histogen were actually in here answering question until dorkins scared them away.

[CAlex]

@HairTalk Im definitely still very excited about histogen and in no way have given up on Follica. Histogens pre clinical results have been the best regenerative results EVER and Follica has always just chosen the stay quiet and just work approach. I have no clue why Follicas continued silence causes people to freak out. They dont need more funding currently so whats the point of talking?

I think we are all glad to just have another legitimate approach being pursued.

Why is there such a gap between phase 1 completion and phase 2 beginning in your timeline hairtalk?

[HairTalk]

RepliCel:

~March, 2012: Phase I of testing complete; results available.

~Early 2014: Phase II begins: 3 mos. to enroll pts.; 3 mos. to replicate/inject cells; 6 mos. till follow-up.

2015: release, if all goes well.

[HairTalk]

So, are we all jumping from the Histogen bandwagon onto the RepliCel, now?

[Penny Stock]

I can't seem to edit my first post but I made a mistake.

It was Intercytex who were cultivating the DP Cells.
Aderans research brought there intellectual property.

Aderans research is cultivating two types of cells,
dermal cells and epidermal cells.

[Penny Stock]

Ps. Here's some light reading

http://www.freepatentsonline.com/y2011/0130711.html

and a video

[Penny Stock]

Dear Spencer...

Thanks for the valueable info that you are providing us about future treatment. However im lost...

Whats really the difference between REPLICEL AND HISTOGEN?

They sound the same and the 2nd part of my question is

Which do you think make more sense and could be achieved sooner?

Hey Man,

I'll summarise this as best as I can, however without reading all the available documentation you’ll probably struggle to grasp it fully.

Histrogen use a process that is designed to mimic an embryonic state, from that they utilise different parts of the bi-product for different applications.(They are not solely looking for a hair loss cure). And they are using the naturally secreted growth factors, proteins from that process to stimulate hair growth.



It’s really Aderans research and Replicel that have the most in common.


The fundamental differences, and advantages over the likes of Histrogen are, that they are both using, and multiplying D.H.T resistant hair cells. This is great because the cells come from your body, and they are the exact cell required for hair regeneration.


The difference between Aderans research and Replicel, is really the type of hair cells they are using and the incubation time.

Here's a link to Replicels paper on: Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla.

http://www.nature.com/jid/journal/v121/n6/full/5602058a.html

It was around this time patents were applied for internationally.

Aderans research cultivates there D.P cells for 6-8weeks
Replicel cultivates there D.S.C cells for 12weeks.

Considering Exponential growth, with regards to cell division, it’s probably safe to assume Replicel are producing well a lot more cells, for the use in their experiments.

I could go on but the information on all four companies is readily available.

I'm sure you'll find some interesting info out there, if you look hard enough.


Happy Googling.

[BoSox]

Wait for results, then predict a timeline. Let's all just be excited about this.


It's that simple.