Where the hell is Desmond?

[mlamber5]

Forgot to add also, everyone thinks that there are 1,000,000 different things going wrong in the scalp of a AGA person and that is why the riddle of AGA has been so hard to crack/won't be cracked. I'm of the opinion that there is probably ONE thing way out of wack which is directly causing everything else to be wrong. It clearly takes androgens to kickstart this "one thing." in genetically susceptible individuals.

[sdsurfin]

Desmond has been away for a long time and a lot of things have changed. We found out pretty conclusively that a low dose of CB does very little. we know that because cosmo upped their concentration by a ton in their new trials. We also know the vehicle is not the issue. Unless you are rich, don't waste your time on CB right now, it is too expensive at the proper concentrations and we won't even know itv its working unless you use it exclusively.

Secondly, PGD2 is not very far downstream from the androgen receptor. Inflammation wise it is probably the most important pathway, and there is a reason that cotsarellis (most knowledgeable hair dude perhaps in the world) and kythera (successful medical company are putting their chips behind it. They know more than desmond does, trust me. You probably don't have to block or fix all downstream pathways to retain your hair. if you can use one pathway strongly enough, it may make the other ones unimportant. just gotta keep the hair growing. that is what follicept is after. Setipiprant might not end up growing back tons of hair, but neither will CB, and my guess is that they release setipip at the same time as something like bimatoprost or SM, which will act as growth agents.

Folicept is also very valid in terms of the science and potential, we just have to see if it does what its supposed to.

Stem cell wise I think desmond is correct, although even a near term breakthrough will require a ton of trials to come to fruition. don't count replicel out either, they have the backing and funding now, and if their trials go well then they are in good shape.

Hopefully hear back from TLR about OC and such in the near future. I will ask him about CB, perhaps he can get it at a price that is reasonable for the higher concentrations needed.

[Artista]

Good to see you back on Desmond

[Kiwi]

Yup good to see you.

You and sdsurfin need to bang heads and get each other up to speed

[sdsurfin]

Yup good to see you.

You and sdsurfin need to bang heads and get each other up to speed

Always happy to talk to desmond. have really appreciated his efforts and positivity. Sometimes his hopes are a bit far sighted and he lets himself get carried away with a conviction, but always a pleasure to read his posts. Definitely a lot to be kept up to speed on though.

[nameless]

Stem cell wise I think desmond is correct, although even a near term breakthrough will require a ton of trials to come to fruition. don't count replicel out either, they have the backing and funding now, and if their trials go well then they are in good shape.

I disagree with you here. Once they figure out how to make implanted cells grow a good amount of hair the treatment could be on the market within a couple years. There are countries that allow treatments into the marketplace quickly. A good example would be ADSCs, which are already available in some countries, including at least one European country, even though they have not been through thorough FDA-type human clinical studies.

[mikes23]

I have to agree with nameless. We all know in Japan they can push it through relatively quick, and almost every country are using some type of 3d printed organ. If we get these lab follicles to grow when implanted, we could see it out on the market pretty quick. I feel like we will get the breakthrough soon. An Italian research team is talking about having bioprinted eyes by 2027. I can't see how implanting and getting a follicle to grow to be harder then having your eyes replaced with 3d printed ones. But who knows with hairloss.

[sdsurfin]

I have to agree with nameless. We all know in Japan they can push it through relatively quick, and almost every country are using some type of 3d printed organ. If we get these lab follicles to grow when implanted, we could see it out on the market pretty quick. I feel like we will get the breakthrough soon. An Italian research team is talking about having bioprinted eyes by 2027. I can't see how implanting and getting a follicle to grow to be harder then having your eyes replaced with 3d printed ones. But who knows with hairloss.

Who knows, but it will definitely take more than a couple of years. Japan has the best stem cell laws around, and they still have to go through two phase trials before they can apply for commercialization. Preclinical, plus phase1, plus phase 2 is minimum like 5 or six years, and thats only once you have it all worked out. The average time for a new drug to get commercialized in the states is around 12-16 years. So chop off a few years if it's in japan and it still takes a while. Just look at how long its taken replicel, they had their concept locked down like a decade ago and they still probably have 3 or four left if they are lucky. It never moves as fast as you think it will and we are still pretty far from a full proof method for regeneration. Hopefully we keep improving at a steady rate though, and things like replicel pan out. and hopefully things move fast not only with hair but in all types of medicine. I hope they make some progress with things like cancer as well, because one day most of us are going to have to worry about worse health related things than hair loss.

[Kiwi]

Who knows, but it will definitely take more than a couple of years. Japan has the best stem cell laws around, and they still have to go through two phase trials before they can apply for commercialization. Preclinical, plus phase1, plus phase 2 is minimum like 5 or six years, and thats only once you have it all worked out. The average time for a new drug to get commercialized in the states is around 12-16 years. So chop off a few years if it's in japan and it still takes a while. Just look at how long its taken replicel, they had their concept locked down like a decade ago and they still probably have 3 or four left if they are lucky. It never moves as fast as you think it will and we are still pretty far from a full proof method for regeneration. Hopefully we keep improving at a steady rate though, and things like replicel pan out. and hopefully things move fast not only with hair but in all types of medicine. I hope they make some progress with things like cancer as well, because one day most of us are going to have to worry about worse health related things than hair loss.

You do realise USA phase 2 trials are recognized in Japan right. So Histigen don't need to go through all of that.

Reading between the lines over the years my interpretation, albeit optimistic, is that they are working on efficacy and hope will have some in the Japanese market sometime soon.

[BiqqieSmalls]

You do realise USA phase 2 trials are recognized in Japan right. So Histigen don't need to go through all of that.

Reading between the lines over the years my interpretation, albeit optimistic, is that they are working on efficacy and hope will have some in the Japanese market sometime soon.

Well, according to RepliCel's newest release (http://www.replicel.com/wp-content/u...Final-2015.pdf) on page 7 it states that data from the phase II trials in Japan will be released by early 2017

[joachim]

i would like to hear desmonds opinion on the IGF1 thing. he's definitely good at interpreting studies and science.
also, arashi and hellouser have been relatively quiet lately.
arashi's investigational skills would be nice here.

[nameless]

i would like to hear desmonds opinion on the IGF1 thing. he's definitely good at interpreting studies and science.
also, arashi and hellouser have been relatively quiet lately.
arashi's investigational skills would be nice here.

joachim, different posters have posted numerous different study abstracts that make it clear that some respected researchers have been investigating IGF to treat hair loss and it has shown some promise. Why do you need Desmond to tell you that? Desmond would probably be as surprised by this as we are. He would need time to go over the scientific studies that have already been done.

That aside, I would have no faith in anything that clown Arishi has to say. Don't forget that he's the same clown who accused needhairasap of being in cahoots with the makers of Pilox to cheat us all. LOL.

And Hellouser is merely moderately reasonable and intelligent. You would be better off just looking at the posts that have IGF study abstracts and contemplate what those abstracts are telling us. I will tell you that those abstracts are telling us that some respected hair loss researchers think that IGF COULD lead to reversal of hair loss. They aren't sure it will work but they say it should be investigated.

[joachim]

joachim, different posters have posted numerous different study abstracts that make it clear that some respected researchers have been investigating IGF to treat hair loss and it has shown some promise. Why do you need Desmond to tell you that? Desmond would probably be as surprised by this as we are. He would need time to go over the scientific studies that have already been done.

That aside, I would have no faith in anything that clown Arishi has to say. Don't forget that he's the same clown who accused needhairasap of being in cahoots with the makers of Pilox to cheat us all. LOL.

And Hellouser is merely moderately reasonable and intelligent. You would be better off just looking at the posts that have IGF study abstracts and contemplate what those abstracts are telling us. I will tell you that those abstracts are telling us that some respected hair loss researchers think that IGF COULD lead to reversal of hair loss. They aren't sure it will work but they say it should be investigated.

sorry, but i have more respect for arashi's and hellouser's opinion than for yours. they, and desmond too, have much more useful knowledge.