We have 3 companies working on topical "side free" finasteride equivalents

[rdawg]

I think realistically, some people need an internal AA on top of RU. There's a study (I'll look for it), which says something like RU blocks 70% DHT at the AR, and also it stays active at the AR for ~20hr. So if you have high levels of DHT in the scalp, and are only applying once a day at 5% for example, and your a person with aggressive MPB, fin/dut may be needed on top of that.

I do believe if you use RU and fin and still lose hair the loss may not be androgen related there must be other things at play.

100% im under the aggressive hairloss category and agree with this.

Fin works for me in terms of slowing down the loss alot, but since starting on it I'd say i've lost about 5% of my hair(hairline has receded a little bit more and density has gotten a little bit worse), noticeable for sure but I can hold off until I can find something to add to this.

I dont like RU personally with the sides i've heard from it and it's untested, so i'm holding out for someone to start pre-mixing CB with the proper vehicle as I think it has a much higher safety profile.

[deuce]

The problem is there are no good AA topicals. Unlike many on here I do take issue buying an experimental chemical from an unregulated company overseas to try playing chemist in my basement.
If we have some real proven packaged and tested solution like CB or something it would be a whole different story. Then its regulated and you know for sure what your getting and that its safe to use long term.
The way guys on here talk you would think RU and CB are perfectly safe and legit to use. Why even bother with FDA trials if its already safe and ready to roll? Drop it in some alcohol mix and stock it out next to the rogain and save us all the 3 years of trials. Seems like a waste of time and money for FDA and companies pursuing this if its already done

Not trying to sound like a jerk or anything here, but if you give the FDA so much validity why don't you not worry about a topical and just take fin. They approved that so they must be spot on right?

[burtandernie]

The problem is there are no good AA topicals. Unlike many on here I do take issue buying an experimental chemical from an unregulated company overseas to try playing chemist in my basement.
If we have some real proven packaged and tested solution like CB or something it would be a whole different story. Then its regulated and you know for sure what your getting and that its safe to use long term.
The way guys on here talk you would think RU and CB are perfectly safe and legit to use. Why even bother with FDA trials if its already safe and ready to roll? Drop it in some alcohol mix and stock it out next to the rogain and save us all the 3 years of trials. Seems like a waste of time and money for FDA and companies pursuing this if its already done

[Tenma]

On the other hand I've heard of countless guys dropping dut and switching to RU with success.

I think realistically, some people need an internal AA on top of RU. There's a study (I'll look for it), which says something like RU blocks 70% DHT at the AR, and also it stays active at the AR for ~20hr. So if you have high levels of DHT in the scalp, and are only applying once a day at 5% for example, and your a person with aggressive MPB, fin/dut may be needed on top of that.

I do believe if you use RU and fin and still lose hair the loss may not be androgen related there must be other things at play.

We agree some will need to use them both to maintain their hair. It could be risky for them long term to rely on one drug only. They surely need a synergic approach. A 2-a. reductase inhibitor combined with an androgen receptor blocker should do the trick.

But, like you said, much more people using only a strong topical AA are having good success, which could mean that for guys in very early stages of MPB, a strong topical AA will do the trick.

[Dan26]

The very few people claiming having lost ground while on RU almost never showed evidence (pictures) of that happening.

Nevertheless, i think the better approach for maintenance will be the combination of DUT and CB/RU.

Remember that Hamilton long term studies already proved that strong androgen desestimulation stops the balding process, even after puberty.

If you have some study or properly documented cases of ru users losing their hair i'd really like to read-seeing them

I can say that my hairline definitely continued to recede while on RU. Took it for 8 months alone, then added fin, then dropped fin for dut. I have photos to prove it but just take my word. My friend also did not have great success with RU but when he dropped it and started fin/minox, had great success.

I still use it now anyways on my hairline, not sure if it does much, but doubt it hurts, and probably provides a bit of insurance.

On the other hand I've heard of countless guys dropping dut and switching to RU with success.

I think realistically, some people need an internal AA on top of RU. There's a study (I'll look for it), which says something like RU blocks 70% DHT at the AR, and also it stays active at the AR for ~20hr. So if you have high levels of DHT in the scalp, and are only applying once a day at 5% for example, and your a person with aggressive MPB, fin/dut may be needed on top of that.

I do believe if you use RU and fin and still lose hair the loss may not be androgen related there must be other things at play.

[Tenma]

some ppl still lose ground on AAs and CB will be no different

The very few people claiming having lost ground while on RU almost never showed evidence (pictures) of that happening.

Nevertheless, i think the better approach for maintenance will be the combination of DUT and CB/RU.

Remember that Hamilton long term studies already proved that strong androgen desestimulation stops the balding process, even after puberty.

If you have some study or properly documented cases of ru users losing their hair i'd really like to read-seeing them

[jamil]

Man, I went on dut and I had to piss all the time and got a tingling burning in my prostate. Basically I got prostatitis ie inflammation of the prostate. Sucks

Been off for 2 weeks now or so, everyday is getting better. Im getting on ru now and then trying again with fin ( I only did 5 days of dut cause I was rightfully worried about the half life).

Man the same thing happened to me two years ago. But in my case was because I stopped using Fin, I was using 2.5 mg at that time and I stopped suddenly because of side effects and the prostatitis started. I went to see many doctors and they prescribed me Sulfameth and work but not very much. Then I went to see some other doctors until finally after the third antibiotic the prostatitis ended. It is a pain in the ass bro, literally hahah

[burtandernie]

Im not using CB at all since its an experimental chemical not approved to be safe to use in humans yet
I dont think we know if RU or CB works as of right now. I dont know of any large scale phase 3 type studies in humans done using RU or CB. Without those I dont know how we guess at well something like RU should work as an AA. I think evidence says a strong enough AA should stop MPB long term by preventing it. I am just basing that off of the past history of those studies showing castration prevents MPB. I could be wrong though.

[HARIRI]

Yeah 4 years from now men will be like MPB what? Just use your CB everyday like brushing your teeth and its a thing of the past. All of course assuming you start preemptively before you lose any hair. We know its not going to fix MPB for those that are in advanced NW.
I still dont think any results using these experimental chemicals means anything as to what actual results in a final product will be. Its also dangerous.

burtandernie, which CB are you using these days? Are you applying it once a day? Im actually thinking of applying it along with my Regaine 5%.

COB984, Did you face any sexual sides with CB-03-01? Are you still using it? From where do you buy it from? Thanks.

[Dan26]

Yeah 4 years from now men will be like MPB what? Just use your CB everyday like brushing your teeth and its a thing of the past. All of course assuming you start preemptively before you lose any hair. We know its not going to fix MPB for those that are in advanced NW.
I still dont think any results using these experimental chemicals means anything as to what actual results in a final product will be. Its also dangerous.

man CB is not even as potent an AA as RU yet RU doesn't automatically save everyones hair

some ppl still lose ground on AAs and CB will be no different

[burtandernie]

Yeah 4 years from now men will be like MPB what? Just use your CB everyday like brushing your teeth and its a thing of the past. All of course assuming you start preemptively before you lose any hair. We know its not going to fix MPB for those that are in advanced NW.
I still dont think any results using these experimental chemicals means anything as to what actual results in a final product will be. Its also dangerous.

[HARIRI]

except you wont save your dick on RU

Yes trust Cob984, he is the only member I know that tried all of these stuff from Finasteride to RU to CB. According to him, the only thing that did not cause sexual sides was the CB but he suffered it from it in another way I believe.

Cob984, if they will produce a topical Finasteride without any sexual sides then would you give it a try? However scientifically I still don't get it! How will it not cause any sexual side as long it will absorbed in our body system!!!

[Cob984]

Theres always RU aswell. Expensive as ****, but I'll take it to save my dick.

except you wont save your dick on RU

[hellouser]

Theres always RU aswell. Expensive as ****, but I'll take it to save my dick.

It's really not THAT expensive;

10g for $225. Use at 50mg/1ml once a day and it will last you 200 days, or basically 6 months.

[LMS]

It probably will but like fin its not usually the case. Stopping hair loss is the most you can count on and any growth is just a lucky bonus. Most times the regrowth is not that cosmetically significant anyways its not like most guys are jumping ahead norwood levels or anything.
I would think CB basically does the same thing, but anything is really possible until we see more. It just really hurts to think about 3 more years with just finasteride as you option for prevention

I agree about why propecia did not turn out that well and I think a topical that has no chance at sexual sides will do a lot better. I dont think the idea of taking a drug in general sits that well for most guys just to keep hair and ever that might be a losing battle long term. If CB or one of these topicals could become over the counter someday next to rogain that is the big win I think. It will be much easier to get, and the cost will come down when it sells in mass because people dont need to see a doctor to get it

Theres always RU aswell. Expensive as ****, but I'll take it to save my dick.