8th World Congress For Hair Research - Korea (2014)
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VERY EXCITING NEWS
Hey guys, the abstract titles for this year's Hair congress just got announced and some of these talks look absolutely ground breaking. Here's the TOP SIX presentations that I picked out which show 6 different research teams cracking the DP culturing problems, while another team has found what makes the DP cells in the MPB zone so different to the permanent zone. It's also interesting to note that these 6 teams are NOT part of the Chinese or Taiwanese teams we already knew about.
It seems that this beast is about to be crackedI will post more information once more information is published. Science is finally giving us the answers we were waiting for
Here are the titles:
1) P032: GENOME-WIDE EXPRESSION PROFILE ANLYSIS OF 3D CULTURED DERMAL PAPILLA CELLS FROM ANDROGENIC ALOPECIA PATIENTS
Weixin Fan
2) P081 (WS3): DERMAL-EPIDERMAL INTERACTIONS IN 3D CULTURE RESTORE MARKERS OF DERMAL PAPILLA INDUCTIVITY
Aaron Gardner
3) P082 (WS3): 3D MICRO HAIR FOLLICLE CULTURE IN A DYNAMIC CHIP BIOREACTOR
Beren Atac
4) P202 (SY10): REPROGRAMMING REGULAR SKIN FIBROBLASTS INTO HAIR INDUCING DERMAL PAPILLA CELLS
Carlos Clavel
5) P221 (FC6): ENHANCING EXPRESSION OF HAIR INDUCTION MARKERS IN HUMAN DERMAL PAPILLA CELLS
ARP Sari
6) P228 (SY3): OPTIMIZED PREPARATION OF DERMAL PAPILLA CELL (DP) AND DERMAL SHEATH CELL (DS) CONSTRUCT FOR HAIR REGENERATION
Koji Kanayama
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On a side note, the third title points out to growing hair germs (microtissues) in a bioreactor to maturations prior to transplantation. Sounds very cool!
What a great year so farA big thumbs up to all these researchers working towards a final cure.
Nothing.
Just a dead concert of scientists that are still all 30 - 40 years away from even clinical trial.
Its over.Leave a comment:
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Hey HellSorry I was so excited I forgot to post the link. Here's the link to titles of all abstracts:
Cheers
This one in particular looks the most promising for the immediate future:
3D MICRO HAIR FOLLICLE CULTURE IN A DYNAMIC CHIP BIOREACTOR
I don't know how far advanced this is, but if they can grow follicles (to perfect completion) in a bioreactor outside the body then that should mean they can create an unlimited donor supply because if they can create one follicle then why not 100,000?
The other subjects appear to be simply re-creating results that others have already accomplished or slight advances, but creating bioreactor follicles could be huge if they are producing perfect follicles. It would probably have to go through clinical trials but that doesn't seem fair because really all they're doing is growing your own hair outside your body and then sticking it back in you.Leave a comment:
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2 important points:
1. This thread is not supposed to be an "attack-Nigam-thread" so please stop the attacks against Nigam. Everyone knows that there are some posters who think Nigam is OK so when the Nigam-haters do attacks against Nigam they're starting arguments about whether or not Nigam is positive or a negative. It would be OK if this were a Nigam thread but it isn't. The Nigam haters initiate arguments about Nigam in threads that are not even about Nigam and they should stop. I'm happy to discuss Nigam in a Nigam thread but please stop ruining every thread with the Nigam attacks.
2. It looks to me like there may not be any new breakthrough at the 2014 Hair Loss Congress. It looks to me like all they have accomplished so far is to replicate Jahoda's study from last year. I don't see where any of the 2014 Hair Loss Congress abstracts involve increasing trichogenicity in cultured DP cells beyond what Jahoda already presented last year. It looks like the 2014 Hair Loss Congress abstracts refer to "partial" preservation of trichogenicity just like Jahoda's 2013 study but no improvement beyond that.Leave a comment:
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Although I truly dig the positivity that posters like desmond have, I think that there's a strong case to be made for not getting overly optimistic about all this stem cell stuff.
I think it will definitely end up curing hair loss, but I doubt it will be anytime soon enough for it to matter for anyone over 25. Just because they are able to recover some of the inductive capabilities of dermal papillae does not mean that they can grow a follicle that will thrive on your scalp, or even a follicle that is similar to the ones you lost. they are now able to make crappy hairs by combining these cells, but interaction of the genes/ factors/proteins that work together to make a fully cycling, anatomically correct hair are so much more complicated than just implanting some DP cells. They still have no idea whatsoever what makes bald scalp different than non bald scalp.
Even once they master growing new follicles, getting them to grow in a cosmetically appealing manner is another ten years of work probably. I'd say we're looking at twenty more years before they can really put baldness to rest with stem cell technology. They are frustratingly close, but I don't think we're even close to starting trials. When Jahoda and tsuji cite the "near future", i think they are thinking more along the lines of 10 years to start trials than say next year.
The abstracts from the hair expo are great titles, but if you do research into any of them, you'll see that the actual experiments are very far from solving the issues that they delineate in the titles. The main problem, as Tsuji has stated, is figuring out the connections between a new follicle and the recipient environment. I suspect that balding has more to do with the genetics of the surrounding skin than just the stem cells of the follicle itself. I also suspect that they will have to build more than just a cell grouping, but instead a whole, follicular unit type of micro-environment if the hair is to grow. Also, how will they control hair cycling? If anyone has a counterargument or knowledge as to why a cure might come sooner, please respond, cause I'd like to be more optimistic. I very much doubt that a chemical treatment or cure will be any good, propecia is poison and it doesn't look like CB or histogen or any of those things actually work very well.
I looked at some of the 2014 Hair Loss Congress study abstracts and it looks to me like the researchers are saying that they have found ways to protect some of the trichogenicity of dp cells in culture. They are not saying they have found ways to protect ALL of the trichogenicity. I think they will need to protect all, or almost all, of the cellular trichogenicity in order to solve the problem.Leave a comment:
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That's great that propecia saved your hair, but judging by what it did to my body in the months that i took it, i can't really call it anything other than posion. It blocks the action of an enzyme that's necessary in most of your body, as well as an androgen that we still dont totally understand the role of. and that alone makes me view people who think they are not going to get damaged by it with skepticism. If it works for you then maybe it's worth it, but for me it hurt my brain and my testicles, and who knows what else that i wasn't feeling.
Even if they are making perfect follicles, the question then becomes: why should these follicles thrive on a balding scalp? When someone goes bald, the fat layers decrease, sebaceous glands shrink etc etc- a whole host of reactions and chemical links that are native to that part of the scalp and not the DP cells.
Oh and PS, Nigam is speaking twice at that congress, so either the congress is kind of lax, or the guy is being taken seriously by someone. My guess is that he's actually well versed in hair science and means well, but India is just such a messed up place that he resorted to using made up stuff to jump start his business.Leave a comment:
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Oh and PS, Nigam is speaking twice at that congress, so either the congress is kind of lax, or the guy is being taken seriously by someone. My guess is that he's actually well versed in hair science and means well, but India is just such a messed up place that he resorted to using made up stuff to jump start his business.
I just looked at the abstract and 'Vivek Nigam' IS presenting at the congress;
* P156 (FC3)
APPLICATION OF TISSUE ENGINEERING IN HAIR TRANSPLANT TO REDUCE AND/OR ELIMINATE POST FOLLICULAR UNIT HAIR TRANSPLANT MICRO SCARING OR WHITE DOTS AT DONOR SCALP.
Vivek Nigam
P157
A CASE STUDY OF HAIR DOUBLING, GROWING 2 HAIR FOLLICLES FROM 1 BY TRANSVERSE BISECTION AT DERMAL CUP SHEATH, SUPPORTED WITH EPITHELIAL STEM CELLS & FRESH DERMAL PAPILLA CELLS
Vivek NigamLeave a comment:
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also
This DP culturing and micro-organ creation is only really a cure if the secret to non bald scalp is non balding DP cells. My guess is that the entire scalp environment is different, as well as the signals between the body as a whole and the balding scalp. Transplants bypass this issue by moving the implanted follicle in a substantial chunk of donor skin. I would love to know how exactly DHT begins and mediates the process, and if our androgen receptors exist only on the DP cells or on all different kinds of cells in the balding scalps. If the androgen receptors are only on the DP cells, then maybe this is indeed a cure that will work soon. The frustrating thing about this forum is that there doesn't seem to be anyone on here that actually knows much about this kind of science beyond the basics.
Then again, if the newly formed follicles are not DHT resistant, they may still function for a number of years, which means a re-up on your treatment. I'm incredibly curious to know how the taiwanese study will go, someone on this forum that is in that part of the country needs to work on a connection there, it's gonna suck to have to wait til 2016 or whenever that study is over.Leave a comment:
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response
I'm definitely making an educated guess, but it is a guess. Basically trials have proven to take about ten years, and I'd say we have about ten more years before we really understand the human scalp and why it acts the way it does.
That's great that propecia saved your hair, but judging by what it did to my body in the months that i took it, i can't really call it anything other than posion. It blocks the action of an enzyme that's necessary in most of your body, as well as an androgen that we still dont totally understand the role of. and that alone makes me view people who think they are not going to get damaged by it with skepticism. If it works for you then maybe it's worth it, but for me it hurt my brain and my testicles, and who knows what else that i wasn't feeling.
The chinese team as well as jahoda's team have made great steps towards rehabilitating DP cells, I know. However, nowhere do they say that they "solved" issues like hair size and color and cycling etc. they simply say that a number of genes were expressed to a greater extent. Even if they are making perfect follicles, the question then becomes: why should these follicles thrive on a balding scalp? When someone goes bald, the fat layers decrease, sebaceous glands shrink etc etc- a whole host of reactions and chemical links that are native to that part of the scalp and not the DP cells. I could be totally wrong, I'm not a hair scientist, but I've read a lot about this and I'm not so sure that just inducing hair = a cure. I think a cure could possible come in the form of donor regeneration (could wesley add DP spheroids to clipped donor follicles?), but until we know why some scalp goes bald, I doubt any attempts to inject stem cell groupings will work. thats just my hunch.
Oh and PS, Nigam is speaking twice at that congress, so either the congress is kind of lax, or the guy is being taken seriously by someone. My guess is that he's actually well versed in hair science and means well, but India is just such a messed up place that he resorted to using made up stuff to jump start his business.Leave a comment:
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Even once they master growing new follicles, getting them to grow in a cosmetically appealing manner is another ten years of work probably. I'd say we're looking at twenty more years before they can really put baldness to rest with stem cell technology. They are frustratingly close, but I don't think we're even close to starting trials. When Jahoda and tsuji cite the "near future", i think they are thinking more along the lines of 10 years to start trials than say next year.Leave a comment:
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Just because they are able to recover some of the inductive capabilities of dermal papillae does not mean that they can grow a follicle that will thrive on your scalp, or even a follicle that is similar to the ones you lost. they are now able to make crappy hairs by combining these cells, but interaction of the genes/ factors/proteins that work together to make a fully cycling, anatomically correct hair are so much more complicated than just implanting some DP cells. They still have no idea whatsoever what makes bald scalp different than non bald scalp.
At least according to this 2005 study (Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells):
The small size of the reorganized HF found in our study can be explained by restricted proliferation of injected DP cell and therefore a small and irregular volume of the developed DP, which has been demonstrated to directly influence HF size and hair shaft diameter (27).
our method can enhance and restores DP cells unique characteristics in vitro.
We examined expression of several genes and protein and protein associated with hair inductivity of DP cells , such as NCAM, Versican and α NCAM, Versican and α-SMA, and confirmed that their was elevated in the spheres compared dissociated DP cells
They still have no idea whatsoever what makes bald scalp different than non bald scalp.
I very much doubt that a chemical treatment or cure will be any good, propecia is poison and it doesn't look like CB or histogen or any of those things actually work very well.
Propecia poison???That "poison" saved my hair (been on it since 2003).
Also, you really should read this 2 things:
2011 study by Dr. Alfredo Rossi, is the first comprehensive study on long-term safety and efficacy of Propecia. Click to read Dr. Bernstein's analysis.
Leave a comment:
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Hey HellSorry I was so excited I forgot to post the link. Here's the link to titles of all abstracts:
CheersLeave a comment:
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premature celebration?
Although I truly dig the positivity that posters like desmond have, I think that there's a strong case to be made for not getting overly optimistic about all this stem cell stuff.
I think it will definitely end up curing hair loss, but I doubt it will be anytime soon enough for it to matter for anyone over 25. Just because they are able to recover some of the inductive capabilities of dermal papillae does not mean that they can grow a follicle that will thrive on your scalp, or even a follicle that is similar to the ones you lost. they are now able to make crappy hairs by combining these cells, but interaction of the genes/ factors/proteins that work together to make a fully cycling, anatomically correct hair are so much more complicated than just implanting some DP cells. They still have no idea whatsoever what makes bald scalp different than non bald scalp.
Even once they master growing new follicles, getting them to grow in a cosmetically appealing manner is another ten years of work probably. I'd say we're looking at twenty more years before they can really put baldness to rest with stem cell technology. They are frustratingly close, but I don't think we're even close to starting trials. When Jahoda and tsuji cite the "near future", i think they are thinking more along the lines of 10 years to start trials than say next year.
The abstracts from the hair expo are great titles, but if you do research into any of them, you'll see that the actual experiments are very far from solving the issues that they delineate in the titles. The main problem, as Tsuji has stated, is figuring out the connections between a new follicle and the recipient environment. I suspect that balding has more to do with the genetics of the surrounding skin than just the stem cells of the follicle itself. I also suspect that they will have to build more than just a cell grouping, but instead a whole, follicular unit type of micro-environment if the hair is to grow. Also, how will they control hair cycling? If anyone has a counterargument or knowledge as to why a cure might come sooner, please respond, cause I'd like to be more optimistic. I very much doubt that a chemical treatment or cure will be any good, propecia is poison and it doesn't look like CB or histogen or any of those things actually work very well.Leave a comment:
Leave a comment: