View Full Version : Dutasteride powder dissolved in ethanol/vodka for topical. Few questions!

11-21-2011, 05:18 AM
Dear friends,
Hopefully someone is here who could help me with this!
I am working on my own Dutasteride topical.

I have imported 5 grams of pure dutasteride powder, and I want to use 5mg per day for topical use.

Dutasteride is soluble in ethanol (44 mg / mL), methanol (64 mg / mL) and polyethylene glycol 400 (3 mg / mL), but insoluble in water.

For a solution, I use vodka (40% ethanol). I want to put 5mg dutasteride in 1ml of wodka.
A solution is now made for 100 days: 100 ml (vodka, 40%, so 40ml ethanol) and 500mg dutasteride.

This is now in a jar and I have stirred, shaken, etc., but not all of the dutasteride is dissolved in the solution. You keep seeing bits and dots floating around.

I really want the 500mg to perfectly dissolve in 100ml vodka, so that each dose of 1ml remains the same ...

Does anyone know how to solve this? Is it perhaps because dutasteride is not soluble in water? And vodka contains some water? Or is it neccesary to heat up the solution?

Hopefully someone knows how to help me!
Thank you very much in advance!

11-21-2011, 11:55 AM
Im not a doctor but you should not be messing with that like that. A topical solution can expose the drug to other human beings. It's a known fact that pregnant woman women or male child can be harmed by residue of the meds. Please ask a doctor or go to your pharmacy.
The drug blocks a enzyme in your body from converting testosterone to dht. I don't see how a topical would help anyway.