View Full Version : more finasteride

02-16-2011, 08:36 PM
Every month I go on pubmed.com (the medical literature website) and just 'google' what latest horror stories are being published on finasteride. and every month i am never disappointed:

Fertil Steril. 2011 Feb 2. [Epub ahead of print]

Finasteride-induced secondary infertility associated with sperm DNA damage.
Tu HY, Zini A.

Division of Urology, Department of Surgery, McGill University, Montreal, Quebec, Canada.

OBJECTIVE: To report a case of low-dose finasteride-induced secondary infertility with associated elevated sperm DNA fragmentation index (DFI) and otherwise normal semen parameters.

DESIGN: Case report.

SETTING: University hospital.

PATIENT(S): A 48-year-old man on low-dose finasteride and his 37-year-old wife with normal menses and normal gynecologic exam.

INTERVENTION(S): Determination of sperm DFI and discontinuation of low-dose finasteride.


RESULT(S): The sperm DFI done a year earlier was 30%. This value was unchanged when repeated 2 months later. The patient was advised to stop finasteride. Three months after discontinuing the finasteride, the DFI decreased to 21% and subsequent DFI after another 3 months improved to 16.5%. To date, there is still no documented full-term pregnancy or live birth.

CONCLUSION(S): The significant reduction in DFI within 3 months of finasteride cessation and continued improvement suggests a causal link between finasteride and sperm DNA damage. We hypothesize that low-dose finasteride may exert a negative influence on sperm DNA integrity, resulting in increased pregnancy losses. We suggest that in infertile men using finasteride, sperm DFI should be measured in addition to semen parameters, and a trial of discontinuation of finasteride may be warranted.


DFI of >30% is "poor fertility potential". Good fertility potential is under 15%. Note it took 6 MONTHS of discontinuation and this patient is not yet under 15%. To those 'agonizing' about this drug - if you have your life ahead of you, do you want potentially long lasting infertility or hair?

02-17-2011, 03:35 AM
That kind of thing makes me think a Jason Statham look - with a working dick isnt so bad afterall.

But its fkn hard getting my head around it - vanity is a damn bitch.