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View Full Version : is Minoxidil "Sulfate" really 14x stronger than regular minoxidil?



Zmay1962
11-04-2015, 10:28 AM
I am new to this forum. This my first post. Hello everybody : )

I have used (Kirkland) minoxidil topical in the past with not that great of results after about 18 months worth of use. I am a middle aged female that has recently had a face-lift which pulled my hairline back, plus my hair is thinning....

Pubmed did a clinical study that claims that the sulfated version works exponentially stronger than regular minoxidil, 14x is what is stated in the study.

http://www.ncbi.nlm.nih.gov/pubmed/2230218

Has anyone tried a minoxidil sulfate topical? If not, would anyone have any info or insight or thoughts about minoxidil sulfate?

Surprisingly, I only found one seller selling it on an auction site.

If it is really stronger, shouldn't there be more formulations or different brands available for retail purchase?

I'm tempted to buy some, but would like to get any comments or thoughts about it.

Thanks in advance for any help : )

BradWellington
02-13-2016, 11:09 AM
Hi everybody,

This is my first post.

I can't seem to find much information online about minoxidil sulfate.

I am very intrigued after reading that Pubmed clinical study.

There is one vendor online that states that:

"The price is about 100 US dollars per 5 milligrams. In a 60 ml hair growth solution with 12% minoxidil sulfate, it has 7.2grams of minoxidil sulfate, which will cost more than 100,000 US dollars to procure the minoxidil sulfate for one bottle (one month supply)."

This is simply not true though. I found wholesale bulk powder suppliers of minoxidil sulfate online that sell per kilo. The price for minoxidil sulfate is more costly than regular minoxidil, but Definitely not anywhere close to $100 for 5 milligrams.

But, they are also selling a product on their site which makes me skeptical about there info.

I am very tempted to try minoxidil sulfate, but as I said before, there is not that much user info online.

if anyone has any experience with using minoxidil sulfate as a topical solution, any info would be greatly appreciated.

Zmay1962
03-02-2016, 08:54 AM
(Update)

It has been about 3 and a half months now of me using minoxidil sulfate 5%.

Even though the suggested dosage is 1 ml in the morning and 1 ml in the night. I think I use closer to 5-6 ml's per application.

The results have been quite dramatic. The new follicles that I am growing seem to be thicker than my usual strands.

It took about 3-4 weeks to notice a considerable difference, but I think it is really working great for me.

Also, at about the 4 week mark, I started mixing in DMSO(15%) with my 5% minoxidil sulfate. I don't know if it is a coincidence or just time that has elapsed while using minoxidil sulfate, but I really started noticing more and more new follicles at the 5 week mark after using the DMSO since the 4 week mark.

I have read that DMSO works as a great carrier to help the scalp absorb minoxidil subdermally.

I have also read that regular minoxidil "is not" soluble in DMSO, but I have read posts from users that it not being soluble "doesn't matter".

Would the fact that minoxidil sulfate "is" soluble in water (instead of PG, like regular minoxidil) make it blend with DMSO better? I do not seem to get any precipitate or separations of the solution.

I'll post another update after about another month of use or so.

If anyone else has any experience with using minoxidil sulfate or mixing DMSO with minoxidil sulfate, your comments or thoughts would be greatly appreciated.

Thanks.

May

BradWellington
03-19-2016, 03:10 PM
I also am interested in adding DMSO to my minoxidil sulfate. I still have 2 bottles left. I ordered an 8 oz. bottle of DMSO, and made about a 10% strength mix. I noticed though, that this new mix made my scalp slightly irritated. I only made 1 bottle's worth of that mix, but I am thinking that even 10% is probably too strong.

Are you getting any type of irritation or tingling at your 15% mix?

Could this "tingling/burning" just be a normal part of using DMSO as a carrier?

Zmay1962
03-29-2016, 08:48 AM
Could this "tingling/burning" just be a normal part of using DMSO as a carrier?[/QUOTE]

I have definitely found the addition of DMSO to produce a tingling sensation. I read online that is a typical reaction to DMSO when applied to the skin/scalp.

I would never classify the tingling as a "burning" feeling though. Do you have sensitive skin? I would describe my skin type as being semi-sensitive.

Maybe if you try adding the DMSO at a 5% or less concentration, the tingling/burning feeling will not be as pronounced.

The amount of tingling I get from the addition of the DMSO is comparable to a hair loss product I used years ago that contained graviola extract and menthol. The tingling always made at least feel like "something" is going on, even if it was just the menthol causing it.

Did you get any type of tingling sensation when you used the minoxidil sulfate topical alone?

eighteen
03-31-2016, 06:37 PM
This thread is shady...

JohnMPB
04-01-2016, 03:44 PM
thread is useless without pictures

BradWellington
04-17-2016, 05:17 PM
"Did you get any type of tingling sensation when you used the minoxidil sulfate topical alone?"



I felt a very very slight tingling, almost not noticeable, when I use the minoxidil sulfate alone.

I ordered more minoxidil sulfate, and this time, I only made a 5% DMSO concentration, and I have not noticed any irritation at this level.

I was just wondering about one thing when it comes to applying minoxidil topicals.

I read online that it is best to apply the topical after a shower, because allegedly, the scalp/skin becomes "water-logged" and is less likely to repel any topical and makes it easier for the scalp to accept the solution topically.

I have been doing this before I apply the minox. sulfate topical. Could this maybe be the reason why I might be feeling the slight tingling/slight burning sensation?

I have been definitely been seeing new thick strands in the front of my hairline, and the rest of my hair seems to be getting thicker.

How's your progress been going?

Do you have any photos that you wouldn't mind sharing?

I highly appreciate your input or thoughts, even without pictures, but it would be great to see any photo documentation.

I'd be willing to swap progress photos with you, even privately, if you wouldn't mind. Thanks B.W.

Zmay1962
04-23-2016, 03:04 PM
I just ordered another 2 bottles of minoxidil sulfate.

This time, I selected the option to have my minox sulfate come with an added 0.25% Retinol. Pubmed did a study on how retinol is supposed to aid with the topical absorption of minoxidil.

So, now I have my old minox sulfate with my added DMSO to help as a carrier and my two new bottles that contain the .25% Retinol.

I'm not sure if I should ad DMSO to my minox sulfate w retinol, maybe that would be too many "carriers" for absorption ( I don't want it to absorb to deep where it penetrates down through my skull bone....JK )

I want it to penetrate as much as I can, to get the best results, but I can't find any info on this 3 ingredient "****tail".

I think I am going to leave the minox sulfate with the DMSO alone, and when that runs out, I will use the sulfate with the added Retinol.

There is no information about this combo online that I was able to find.

Any thoughts would be greatly appreciated.

JohnMPB
04-24-2016, 01:18 PM
Show us pics of the results that are "quite dramatic" unless of course you're a vendor trying to peddle your product.

Zmay1962
06-04-2016, 12:39 PM
Hi,

I do not have any before pics. It got really bad, I wouldn't even go in front of a mirror let alone take any pictures.

I had patches of hair that started falling out , from what I was told by my Dr., was due to being on large doses of nadolol & on and off use of prednisone.

At least that what is what he said might be a main contributor.

I can post after pics, but that would not be any sort of before and after proof....Sorry

I'm not peddling anything.

I honestly thought anything with "sulfate" was a major no-no if you are losing or have thinning hair.

And, although it is scented, it tends to have a very very slight "raw eggs" sulfur smell to it when I leave it on and sweat at all.

But, it is worth it to me.


I have a coupon code if anybody wanted to make a purchase!


JK I HAVE NO COUPON CODE , and am not promoting anything, just my own experiences.

There's not that much user experience info on this subject online, that I could find.

There's some site that is talking bad about minoxidil sulfate, but their facts don't ad up.

Like when they talk about the price.

I checked online, and it is not $1,000,000,000 a gram or whatever that site is claiming that minox sulfate is, but it is more expensive per kilo.

Maybe this won't work for everyone. Maybe because I slightly lowered my meds in the last year, my hair is just naturally growing back.

Regardless, I'm just happy there is hair there.

Anton5redA
06-05-2016, 12:34 PM
Hi Zmay1962
Check your TSH (thyroid function)
Often women lose hair due to even sub--clinical (higher area of normal range) TSH numbers because they are more sensitive to lack of good T3 and T4 levels.
See what the numbers are and if they are not so hot, ask the MD to do something about it (Armour is better than Levothyroxine) Whatever to see if that will solve your issue.
The other treatment you can try is an anti-fingal like Nizoarl shampoo
Give them a chance and see what works.

-Anthony

Zmay1962
07-15-2016, 08:05 AM
Hi Anton5redA,

Until you just mentioned those things, I was never aware of any of them. Should I see my primary care physician to get those tests done?

Also, I never knew anything anti-fungal played a role in hair loss at all. I have been using an anti-fungal topical spray "tolnaftate" for a condition I have that occurs on my upper neck called "tinea versicolor". It is a condition that leaves fungal blotches and spots on my upper and lower neck.

Would I be painting with a broad brush to assume that I could also use this anti-fungal on my scalp/hair?

Thanks a lot for time and input.

May

BradWellington
07-25-2016, 03:49 PM
On the topic of anti-fungals,

I also never knew it played any role in hair loss. I have been using a tolnaftate topical spray on my upper neck for a condition called tinea versicolor that leaves blotches on my skin especially in these hot summer days. Is there any way that could be getting in my blood stream transdermally and effecting my hair loss/growth?

I also stopped using using DMSO in my hair loss topical and am just sticking with the minox sulfate w retinol. The DMSO seemed to "abrasive".

I was thinking of adding caffeine to my mix. I read it can help with stimulating hair folicles. I'm just not sure if enough gets absorbed subdermally to play any type of important role... We'll see.

Teece
08-15-2016, 01:20 PM
(Update)

It has been about 3 and a half months now of me using minoxidil sulfate 5%.

Even though the suggested dosage is 1 ml in the morning and 1 ml in the night. I think I use closer to 5-6 ml's per application.

The results have been quite dramatic. The new follicles that I am growing seem to be thicker than my usual strands.

It took about 3-4 weeks to notice a considerable difference, but I think it is really working great for me.

Also, at about the 4 week mark, I started mixing in DMSO(15%) with my 5% minoxidil sulfate. I don't know if it is a coincidence or just time that has elapsed while using minoxidil sulfate, but I really started noticing more and more new follicles at the 5 week mark after using the DMSO since the 4 week mark.

I have read that DMSO works as a great carrier to help the scalp absorb minoxidil subdermally.

I have also read that regular minoxidil "is not" soluble in DMSO, but I have read posts from users that it not being soluble "doesn't matter".

Would the fact that minoxidil sulfate "is" soluble in water (instead of PG, like regular minoxidil) make it blend with DMSO better? I do not seem to get any precipitate or separations of the solution.

I'll post another update after about another month of use or so.

If anyone else has any experience with using minoxidil sulfate or mixing DMSO with minoxidil sulfate, your comments or thoughts would be greatly appreciated.

Thanks.

May

I have been really interested but just a little scared to use DMSO on my scalp with minoxidil. Talk about it going super systemic. But I have hbp anyway so I don't think that is going to be an issue for me.

I have been taking a teaspoon of DMSO nightly for a while and my health and energy levels have improved. So sad and disappointed about Dr. Stanley Jacob passing several months ago, I have not found another source to buy it.
Thinking about the outfit in OK. Their prices seem to be good and their product states 100% DMSO.

I'm wondering where you are able to purchase this, thx in advance.

Teece

Teece
08-15-2016, 04:03 PM
Wow. Belay the request Zmay1962. It seems that Jeff Jacob, the son of Dr. Jacob has put his father's DMSO business back in business. I couldn't be happier, after all it was Dr. Stanley Jacob who has been practically alone in the minimal research done with this miracle of nature.

Zmay1962
08-22-2016, 06:26 AM
Hi Teece,

Sorry for the late response.

I have been buying my DMSO from Ebay.

They have a lot of different vendors that have a lot of sales and good ratings at good prices.

I looked up the source you said, and the price is significantly more costly, by a lot.

Do you think the quality differs that much?

I hope I am not buying bad or old DMSO.....

BradWellington
09-01-2016, 01:50 PM
So, I am now using my minoxidil sulfate with only 1% DMSO, I felt higher amounts tingled/slightly burned my scalp too much.

I also went ahead and added caffeine at about 5% and mint oil to my concoction, I read mint oil can help with hair growth regeneration. I'm sure it can't hurt.

I am getting positive results though from all of this, compared to when I used to use regular minoxidil.

I'm thinking about maybe buying a kilo of minox sulfate and making my own, when I finally get enough balls to go through with making it myself. I really don't have ANY equipment, but I'm sure I can whip something together. That way I can make a 10-15 or higher percentage of minox sulfate for personal use. I hope too much won't have any adverse effects...But, I'm still a ways off from doing all that.

I'm glad I found minox sulfate. Thanks "ZMay1962" for putting me up on this. Much respect.

BW

Zmay1962
11-06-2016, 05:43 AM
I was looking around for other water-based minoxidil topical & I found an interesting study about how a water-based minoxidil topical has a better bioavailability than a pg based minoxidil solution (they used Rogaine).

It claims that:

"The dorsal skins of rat were treated with various water-soluble minoxidil compositions or 5% Rogaine for 1 hour. The intact or decutinized skins were cut, and homogenized. The permeated minoxidil was extracted and analyzed by HPLC. The results indicated the 2% water-soluble minoxidil composition achieved the same penetrating ability as that of 5% Rogaine."

I found the study/abstract it here: https://www.google.com/patents/US20110112125

I'm not to sure how reliable the study is, I just found it to be interesting since I'm also using a water based minoxidil topical, albeit a different form of minoxidil water based topical.

Could water be a far more superior carrier of minoxidil than PG?

Thanks in advance for any thoughts or comments.

Zmay1962
01-01-2017, 05:51 PM
I did some more reading about Minoxidil sulfate that I found interesting.

I read that regular Minoxidil doesn't work on some individuals because they lack a certain naturally produced enzyme on their scalp/skin, & therefore, they will never see any results.

Minoxidil Sulfate takes care of this problem because whether or not the individual has this "enzyme" it will work regardless.

I can't speak for anyone else, but Minox Sulfate has been a God send for me.

I can even see new hairs that are growing well below my normal hairline (about an inch to an inch & a half). So much so, that sometimes I have to pluck them because they are growing too low below my hairline.

But, that could also be because sometimes I'm in a rush and do not properly wash and Minox Sulfate that drips down my forehead.

I should try applying it to the back of my hand as an experiment to see if I grow hair there,lol.

Take care.