View Full Version : Topical Finasteride 0.1% Foaming Solution 60mL

06-10-2015, 08:16 AM
Hi guys, I can't believe it's almost a year since I posted on this board. Oh how the time flies! I have to say I really missed this place and all the discussions everyone's having. It is definitely a very unique and invaluable community we have here :) Hope you've all been well and haven't allowed hairloss to get the better of you.

So lets get down to business :)

Firstly, please keep in mind that we designed this formulation for preparation in a compounding pharmacy, so it is much more difficult for a layperson to prepare due to the equipment and ingredients necessary for this particular dosage form.

The second issue I would like to point out is the dose. We based the strength on all the research papers available on Topical finasteride, which showed 0.1% is an effective dose comparable to oral finasteride. My personal view however is that 0.1% is far too potent and almost unnecessary for a topical formulation and will most likely lead to side effects we are desperately trying to avoid. So feel free to reduce it down to 0.05% if you want to be on the safe side. That is what I'm going to be trialing myself. So, finally, here's the formulation:

Ingredient List:
1) Finasteride 0.06g
2) Cetyl Alcohol, NF 0.9g
3) Stearyl alcohol, NF 0.9g
4) Cocamide DEA 3.60g
5) Sodium Lauryl Sulfate 12-13%
6) Potassium sorbate, NF 0.06g
7) Methylparaben, NF 0.06g
8) Alcohol 95% 6mL
9) Purified Water 24mL
10) Purified Water qs to 60mL
11) Hydrochloric acid 10% Solution As required

Preparatory Instructions:
1) Preparatory Step:
A. Prepare a hot water bath
Specifications: Temperature: 75 to 80C

2) Powder-liquid preparation
A. Incrementally add the Finasteride to the Alcohol 95% and continue to mix until dissolved.
End result: Homogeneous liauid-like solution

3) Aqueous phase preparation:
A. Using the hot water bath sequentially add the following ingredients to the Purified Water (24.0 mL plus processing error adjustments).
-Potassium Sorbate
Specifications: Continuouslv mix until all solid particles have completely dissolved.
End result: Homogeneous liquid-like solution.

4) Oil phase preparation:
A. Using the hot water bath combine and mix the following ingredients together to form a homogeneous liquid-like dispersion:

-Cetyl Alcohol
-Stearyl Alcohol
-Cocamide DEA

Specifications: Allow the ingredients to melt together without mixing.
Maintain temperature between 70 to 75C
End result: Homogeneous liauid-like dispersion.

B. Using the hot water bath incrementally add the homogeneous liquid-like solution (Step 2A) to the homogeneous liquid-like dispersion (Step 4A) and mix until homogenous.

Specifications: Allow the ingredients to melt together without mixing. Maintain temperature between 70 to 75C

End result: Homogeneous liauid-like dispersion.

5) Phase integration:
A. In the given order, sequentially add the following ingredients to the homogeneous liquid-like solution (Step 3 A).

-Ammonium Lauryl Sulfate 27-28%
-Homogeneous liquid-like dispersion (Step 4B)

Specifications: Continuously mix.

End result: Homogeneous lotion-like dispersion.

B. Once homogeneous, remove the mixture from the heat and continuously mix at low speed until the temperature of the mixture reaches 30 to 35 C.

End result: Homogeneous liquid-like dispersion.

6) Filling to Volume:
A. Add additional Purified Water to the above mixture to fill to the required batch size (60.0 mL plus processing error adjustments)

Specifications: Continuously mix.

End result: Homogeneous lotion-like dispersion.

7) pH testing:
A. Draw an appropriate amount of the mixture (Step 6A).
B. Test the pH of the sample. It should he between 6.4 and 6.6.
C. If the pH > 6.6, carefully add. in a dropwise fashiou the Hydrochloric Acid 10% solution to the mixture:
1. Draw and transfer 1 or 2 drops of the Hydrochloric Acid 10% solution to the mixture.
2. Stir for at least 5 minutes to evenly disperse the Hydrochloric Acid 10% solution.
3. Re-test the pH.
4. Continue to add the Hydrochloric Acid 10% solution until the pH of 6.4 to 6.6 is obtained. IMPORTANT: Do not allow the pH to drop below 6.4.

8) Product transfer:
Transfer the final product into the tight, light-resistant foam dispensing container.

Estimated Beyond Use date: 30 days after preparation
Storage: Keep at room temperature (below 25 C)
Protect from light
Shake well before use.
Do not allow to come into contact with eyes/nose/ear/mouth.

06-10-2015, 08:20 AM
Feel free to ask any questions guys. Again, I can only make this for you if you reside in Australia and can get a prescription from an Australian prescriber. If that is the case, then let me know in this thread and I'll keep you posted. For everyone else however, this is just a guide for you to provide to your pharmacist wherever you are in the world and they can try and make it for you.

Hope this has been helpful ;)

06-10-2015, 08:28 AM
Good to see you back on the Forum Desmond84

06-10-2015, 11:38 AM
Thanks a lot for this guide ! Sad to know we cannot buy online if no Australian :(

I think it will be expensive to reproduce this topical finasteride by a pharmacist !
Better to see the hasson and wong or the Susan's topical ! :(

06-10-2015, 02:19 PM
Hey Desmond can you say the approximate release time of topical fin?
Sorry if I'm the 100th who asks this :D

06-11-2015, 11:02 AM
Does anyone know a reliable pharmacy in the U.S. That will be able to reproduce this formula?
I'm assuming we will have to provide the fin which is not necessarily too complicated... The hard part would be to mix it in a professional manner

06-11-2015, 12:24 PM
Won't this just go systemic anyway?

06-13-2015, 08:56 PM
Good to see you back on the Forum Desmond84

Artista :D How have you been brother. How's piloscopy coming along? Hope all is well ;)

Thanks a lot for this guide ! Sad to know we cannot buy online if no Australian :(

I think it will be expensive to reproduce this topical finasteride by a pharmacist !
Better to see the hasson and wong or the Susan's topical ! :(

Yeah it will be costly. But if it gives people less side effects (fingers crossed) I suppose it's worth it. I was planning to switch to CB-03-01 this year, but Kane was asking for $300 to supply 1 month worth of CB which made it too far out of my price range. So I went back to the drawing board and came up with this topical Fin formulation instead. Hopefully it gives everyone a safer option especially those prone to sides. Only time will tell and it seems we have to wait till 2018 anyways for topical CB :P

Hey Desmond can you say the approximate release time of topical fin?
Sorry if I'm the 100th who asks this :D

Sorry but I'm guessing you're asking about its absorption into the dermal layer? We haven't done any actual human trials on this formulation as you probably have guessed but I would think it should be reaching the dermal layer within one hour. Once it's there it forms an irreversible and inactive enzyme complex with type II 5 alpha reductase, the enzyme responsible for producing DHT in the scalp and miniturisation of hair follicles in men with AGA.

I'm actually trialling this formulation on myself and will keep a log for you guys to review ;)

Won't this just go systemic anyway?

As a general rule, approximately 10% of any topical product makes it to the systemic circulation. So, lets assume that a single application would contain approximately 0.25mg of Finasteride. Now if 10% of that makes it into the systemic circulation, we are looking at 0.025mg of fin entering our circulation. In the Phase 2 "Dose-range finding" studies of Propecia, doses below 0.04mg affected the plama DHT in a very similar pattern to placebo (close to none). I've attached the chart to this post for your reference ;) However, we are significantly lowering scalp DHT (~ by 50%) by applying it directly to the site of action thereby preventing follicle miniturisation while mitigating side effects, at least in theory :)

06-13-2015, 09:13 PM
OK guys, so I made one batch for myself this week and applied it on Friday. I'll keep a log of myself on this thread for you guys to follow as well.

So, first of all, 2012-2014 I took 0.25mg of Oral Finasteride TWICE A WEEK with very good success. I did experience a range of side effects which eventually wore off over the course of 7 months. You can find that story in the link below ;)


Earlier this year I decided to increase my dose to 0.25mg THREE TIMES PER WEEK just to be on the safe side since I was no longer experiencing sides anyways. I take a QUARTER of a 1mg tablet on Mon, Wed, Fri each week. So, that's what I've been on so far.

This week, instead of my Friday dose I applied the topical foaming solution for the first time and I am glad to say that it seems to have worked. Here's how I was planning to gauge its efficacy. As many fin users know, once you skip your fin dose more than 4 days, your scalp feels tight, your temples (balding areas) get extremely itchy and shedding suddenly sets in. At least these were always the symptoms I experienced when I ran out of Fin and didn't get a chance to fill my prescription!

I took my last oral dose on Wed morning and it is now exactly 4 days post oral fin. There is no itch. My scalp feels great and there's no shedding at this point.

Dose applied:
TWO actuated pumps applied. One dose to the temples. One dose to the crown.

My theory is the local scalp circulation should carry it to the mid section anyways and the less you apply the less systemic sides you'll get. I'll keep you guys posted.


Desmond :)

06-13-2015, 09:19 PM
Oh Btw, with regards to the cost:

This should cost around AUD $75.00

The ingredients cost about $30 per bottle, and it takes approximately 1.5-2 hours to prepare, so most Pharmacies generally charge you $30-40 for labour costs. If they're asking for more shop around guys.


I will let you know how long would a 60mL bottle last. I'm hoping at least 2 months since we are only applying three times per week ;)

06-15-2015, 08:48 AM
This is great work Desmond. I think the key here is for someone who has not used Fin orally to check their DHT levels before and after one month of using this foam.

I'm finally posting on forums because this effort from desmond is actually a step forward. The next step forward would be to produce a vehicle that contains no irritants (or very very little) and contains fin, RU (CB is way too expensive) and minoxidil (possibly sulphate but its unstable). The cream could be enriched with some other molecules that encourage healthy skin and fatty layers. Could such a thing exist in the future?

Once again, great work.

06-15-2015, 09:20 AM
Hello again Desmond !

Finasteride has been doing relatively GOOD for me. That is because I am very realistic about life,
generally speaking.
You know what I mean....
Of course, like EVERYONE else, I wish that I still had a full head of hair.
BUT I will not allow hairloss to hold me back from a GOOD life...If someone else looks at my scalp and is disgusted or critical then that person has an issue ~not me.
If I meet up with someone who has significant hairloss, I would never condemn or criticize him or her.
Ill get off of my tangent now-LOL

Desmond, I met up with Dr Wesley at his office in Manhattan about a month ago.
My wife and I had a great meetup-conversation with him.
I will be one of his Pilofocus Phase Test patients approx at the end of this July, maybe in August.
Of course Im not there to get a 'full head' of hair--lol.
I will be a part of his new science to show whether or not Pilofocus will change the course of hair transplantation!
There is a good possibility of this new science succeeding .
But no one should hold back from living their lives WAITING,,,you know that Des'

06-15-2015, 09:30 AM
Thats great, but what has it got to do with the threads topic? Not being rude but off topic posts really dilute the available information.

Hair Bear
06-15-2015, 09:33 AM
Nice work Desmond and I have to say your post came at a very important time as I was heavily considering taking oral fin as my doctor many year ago once informed me that he could prescribe it to me but was a little hesitant at the time.
I live in Australia also but have absolutely no idea where to start so if you could kindly assist that would be appreciated.

Once again thanks for your post and also for your positivity not to mention you tireless efforts here.

I never considered fin before but I guess there comes a time where we must each consider the war ahead and face each battle with the tools we have, nothing new has really come to market and I'd rather fight this than cower in the corner waiting and hoping on what may never come.
I've been on these forums for far longer than I expected to be and it is amazing how fast time has gone by but sadly I have not seen any of the advancements I have expected in such a time. I must admit I have dabbled with a topical fin of sorts but it was a terrible mixture and felt like I was rubbing syrup over my head which made it clearly unsuitable for day to day life. (The name escapes me right now but I have commented on it before in another thread)

06-15-2015, 09:48 AM
Hi OneOff.
You DO make a good point..I was just answering Desmond question.
I dont mean to take this off-topic. Cheers

06-15-2015, 12:31 PM
Desmond, thanks for the information!

As you can imagine for most of us finding the right pharmacy and the ingredients wont be a walk in the park so I was wandering what would make this vechicle unique vs mixing fin with something much easier to find like rogaine?

I'm sorry if this has been asked a million times but your statement of only 10% will likely to go systemic, I agree the amount should be reasonable to avoid sides so I would like to give it a try with something a regular Joe can prepare at home


06-15-2015, 03:42 PM
Looks very interesting, thanks a lot for your work, Desmond.
Unfortunately, here in Europe, Switzerland to be precise, it is very unlikely you will find any pharmacy which is willing to mix this stuff. You probably won't even get a prescription for it...
I also googled some of the ingredients and some are available but only in large quantities and quite expensive. Therefore not really an option. And I suppose there is not an easy "mix-it-at-home" way?

06-15-2015, 07:28 PM
Hey Desmond,
I have followed some of your threads and must say, your vast knowledge on the subject is very valuable and reassuring to me. I am glad I became a part of this forum. I don't know too much about topical fin, so I have a couple questions. I noticed that "Dr. Klein" is offering a solution that contains certain variations and percentages of minox, fin, azialic acid and progesterone as a topical, spray or cream. Would you recommend such a formula? I know that on their prescription sheet, the percentage of finasteride is .1% as you suggested.

Give it a go
06-16-2015, 10:38 AM
Hi OneOff.
You DO make a good point..I was just answering Desmond question.
I dont mean to take this off-topic. Cheers

if you already have a wife why do you still want your hair so badly?

06-16-2015, 11:31 AM
if you already have a wife why do you still want your hair so badly?

Are you totally letting yourself go if you get married? Wouldn't you watch you weight, your clothing, your appearance in general?
Wouldn't you still like to have a look you feel comfortable with when you look at the mirror just because you are married?
For sure you can be happy without hair but the reason why we are on this forums is because we simple want to feel comfortable we we look at the mirror

06-16-2015, 11:59 AM
Hey mates and Desmond ! Nice to see you back :)

I've been using finasteride 1mg + minox for 2 years (19 years old here) but it doesn't really seem to work out for me (at least from the photos i got), so my question is, would it change anything if i swap to this method ? Or would it pretty much give me the same results?

Hopefully this one gives me a better result, would have to talk with my parents about this tho cause, I have no clue how to get most of those ingredients :p

Cheers !

06-16-2015, 02:17 PM
Thanks Desmond for the great work. SO I can just go to a Walgreens Or CVS and ask them to formulate this for me? I am not sure how this goes.

06-19-2015, 10:41 AM

Thanks for doing this. Two questions for you:

I was looking through your thread about your (oral) finasteride experience. It looks like you've be using 0.25mg twice a week for 2 years and everything's been okay; was that not the latest update? Otherwise why switch to topical?

The other thing I wanted to ask is I thought I remembered you warning people against using microdoses of finasteride because you had a few patients who had tried that and developed prostatitis as a result. Am I remembering that right? Or was that before you did it successfully?

06-20-2015, 10:21 AM
There are compounding pharmacies everywhere, get an prescription and take to them.

06-22-2015, 04:04 AM
Hello Desmond,

Could you provide an update on your topical experience?

Also if you could elaborate a bit more why this vehicle is better than something easier to find like rogaine I will appreciate it very much

07-08-2015, 11:19 AM
@desmond84 any updates on your trial to contribute?