01-25-2014, 09:11 PM
got some Thymosin beta-4. will be using on my pet "kangaroo". will let you know if my kangaroo sees any improvement in hair.
reason for this is because another person had success with a protocol using tb
he used this dosing protocol
8mg week 1 (two shots @ 4mg Monday Thursday)
4mg week 2 (two shots @ 2mg Monday Thursday)
2mg week 3 (two shots @ 1mg Monday Thursday)
2mg week 4 (two shots @ 1mg Monday Thursday)
Then shots of .5mg twice a week for the following 4 weeks
Then maintenance dosages of .5mg-1mg every 2 weeks after that.
01-25-2014, 09:11 PM
" Thymosin β4 increases hair growth by activation of hair
follicle stem cells
Deborah Philp, Mychi Nguyen, Brooke Scheremeta, Sharleen St-Surin, Ana M. Villa,
Adam Orgel, Hynda K. Kleinman, and Michael Elkin
Cell Biology Section, National Institute of Child Health and Human Development, National
Institutes of Health, Bethesda, Maryland 20892
Corresponding author: Hynda K. Kleinman, Ph.D., Cell Biology Section, NIH, NIDCR, Building
30, Room 433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892. E-mail:
Thymosin β4, a 43-amino acid polypeptide that is an important mediator of cell migration and
differentiation, also promotes angiogenesis and wound healing. Here, we report that thymosin β4
stimulates hair growth in normal rats and mice. A specific subset of hair follicular keratinocytes
in mouse skin expresses thymosin β4 in a highly coordinated manner during the hair growth
cycle. These keratinocytes originate in the hair follicle bulge region, a niche for skin stem cells.
Rat vibrissa follicle clonogenic keratinocytes, closely related, if not identical, to the bulge-
residing stem cells, were isolated and their migration and differentiation increased in the
presence of nanomolar concentrations of thymosin β4. Expression and secretion of the
extracellular matrix-degrading enzyme matrix metalloproteinase-2 were increased by thymosin
β4. Thus, thymosin β4 accelerates hair growth, in part, due to its effect on critical events in the
active phase of the hair follicle cycle, including promoting the migration of stem cells and their
immediate progeny to the base of the follicle, differentiation, and extracellular matrix
Key words: matrix metalloproteinase-2 ● clonogenic keratinocytes
he mature hair follicle is a complex miniorgan that has a tightly regulated growth cycle.
During postnatal development, the follicle undergoes successive phases of active hair
shaft production (anagen), apoptosis-driven regression (catagen), and a quiescent phase
(telogen) (1). During the anagen phase, active hair growth involves cell proliferation in the
proximal follicular epithelium, followed by invasion of the elongating follicle into the
subcutaneous tissue, differentiation of the epithelium at the base of the follicle, and formation of
hair matrix cells, which proliferate and generate a new hair shaft. Then a regression phase
(catagen) of the hair growth cycle ensues, during which the lower part of the follicle undergoes
programmed cell death and involution (1�3). At this point, the follicle enters telogen, the resting
period. The cycle is then repeated. The ability of hair follicles to constantly renew is ensured by
the presence of the multipotent stem cells, which, upon division, generate two types of daughter
cells. Some of the daughter cells retain the same multipotent phenotype, while others become
rapidly dividing transit-amplifying (TA) cells, which provide differentiated progeny for the
01-25-2014, 09:13 PM
my pet kangaroo spends most of his recreational time lifting weights and my pet kangaroo is very non needle phobic as he has used Anabolic steroids and many other peds in the past.
01-25-2014, 09:17 PM
blood work shortly before kangaroo started losing hairs in shower. as you can see estradiol is damn near zero. When you block estrogen you get a surplus of DHT.
01-26-2014, 09:18 PM
Lol, I skipped the blood work and was stunned at the kangaroos test level. Then I read the post above and all made sense.
Good luck with it!
01-27-2014, 01:50 PM
lol, kangaroo's testosterone levels have been 4000-5000 ng + in the past.