View Full Version : Bimatoprost interest ?

01-17-2013, 09:31 AM
A good friend of mine had just sent me some info and a link to check out from another website regarding the use of Bimatoprost by a 'Dr. David'
Seems interesting to me....check this out What do you think of this?

"Dr. David 4444
Bimatoprost: Results of 6 mo. usage of Allergan Lumigan

Patient Background:
I am 37 y.o. I earned a Ph.D in biochemistry and an M.D. from a leading U.S. medical school (I don't practice medicine anymore). My hair began receding from the front of my scalp (anterior MPB) at age 26. I was Norwood grade II until age 33. From age 33-37, my hair loss accelerated and I progressed to Norwood grade III (no hair loss in the vertex). I suspect that without any intervention, I will be Norwood grade IV by age 40. I began applying Rogaine 5% over most of my scalp from ages 31-36, but I stopped after seeing very little increase in length, density, thickness, or pigmentation. I have never used any other hair-regrowth product. I believe in the efficacy of dutasteride/finasteride, but I won't risk their side effects. I am aware of other clinical trial-stage topical anti-androgens, but I am wary about using them until more data comes out. I became interested in bimatoprost after hearing several dermatologists tout its efficacy and safety.

I received a prescription for Lumigan (0.03% bimatoprost) from a university-based dermatologist who researches hair loss. A colleague of mine had a contact at Allergan, and this enabled me to purchase large quantities of Lumigan (insurance only covers 1 2.5 ml bottle/month).

I applied at night 1-1.5 ml of 0.03% Lumigan for 6 months (82 2.5 ml bottles total, at a cost of $325/month). I rubbed it into my scalp (from my orginal hairline to the frontal and temporal regions) for one minute with my fingertips.

I used the Allergan brand product to ensure purity and I used a large volume for adequate coverage so that at the end of the trial, if I didn't see results, I wouldn't question the purity of the compound or the volume applied (I would still be left with questions about other variables, such as product concentration and delivery vehicle, which I could address after my study). The dermatologist inspected my scalp and took photos at baseline and every 2 months after.

We did not observe any results during the first 2 months of the trial. But by the end of month 3, the hair on my frontal and temporal areas (2.5 to 4 inches above my original hairline) began to show increased density and thickness. By the end of month 4, we observed increased pigmentation of this hair and some of my miniaturized hairs had a moderate increase in length. These parameters continued to improve up until the end of the 6 month trial.The dermatologist had a computerized videomicroscope. I believe the photos were taken with a 50X lens, but I'm not certain.
I know it is a better analysis tool, but I was not up for the unit area trichogram. Maybe in the future.
When I stopped using Rogaine, I did NOT have a significant immediate shed that occurred over a period of weeks. I believe I continued to lose hair at the rate I experienced before discontinuing Rogaine. This is a based on a qualitative assessment of my hair. I have no quantitative proof of this. It is possible that the rate of hair loss moderately increased.

I experienced no significant new growth in the bald areas of my scalp. Vellus hairs formed, but less than 5% became terminal hairs.

My own subjective assessment of the appearance of my hair is that this treatment has turned the clock back to about a 1.5 years ago.

I experienced no side effects during the trial.

I am satisfied that bimatoprost has stimulated hair growth for my particular case and will significantly slow my hair loss. I am now interested in applying higher concentrations of product to see if I can achieve even better results. The challenge, of course, is obtaining pure bimatoprost compound (designing the vehicle is less of a problem).

I don't know if I can justify the cost of this treatment to others. I really don't have an idea of how much members on this forum spend per month on hair regrowth products. I certainly saw results that were much better than with Rogaine for my particular case, but Rogaine is a small fraction of the cost that I invested.

01-17-2013, 03:12 PM
Isnt Bim using 3% instead of 0.03% in the hairloss trials?

01-21-2013, 02:42 PM
This is interesting enough, but unless we can obtain it for much cheaper and with the same level of purity there's not much to do.

Anyone trying Bit out? I hope it works better than minox but no sides sounds pretty awesome...

01-21-2013, 03:02 PM
Probably works, probably expensive though.

01-22-2013, 05:34 AM
Yeah Allergan is testing much higher concentrations in this trial. There is every reason to think (given the recent paper published by them) that bimatoprost will work on human hair loss.

And given the 0.03% bim seems to be about as effective as 5% minox there is cause for optimism that the higher concentrations will perform even better.

But we have to wait for the Phase II trial results to know for sure. Shouldn't be too long now, the study was completed in September 2012. So Allergan would know the results by now.

Hopefully they release some info about it in the next market results.

01-22-2013, 05:35 AM
The cost should also come down as it gets mass-produced.

How much it comes down is anyone's guess.

01-22-2013, 09:30 AM
Unfortunately I'd spend $325/month in a heartbeat to go up a Norwood and thicken existing hair...

Thankfully I'm in the minority here

I can never get my phases right, is phase 2 a safety test or an efficacy test? If phase 2 results are positive at high dosages could we produce this stuff on our own and have at it? I mean it's not like Histogen or something mysterious; we know and can obtain the stuff now. Whaddya think Pate? Cost aside, is it possible that guys like Kane will be selling MBP level Bit in 2013?

01-23-2013, 04:58 AM
It's possible we will hear something in Allergans quarterly conference call scheduled for Tuesday February 5th...... a little less than 2 weeks.

01-23-2013, 06:44 AM
The cost should also come down as it gets mass-produced.

How much it comes down is anyone's guess.

any idea of when it will be on market?

01-23-2013, 05:38 PM
any idea of when it will be on market?

I read recently somewhere that this product is in Phase II trials and it won't hit the market until about 2 years from now. I do not know how accurate that is considering it is already cleared for the purpose of regrowing eye lashes...but again, that's what I read.

I wouldn't hold my breath on any of these new "treatments" to be released any time soon. It's all politics and I always hear only 5 years out, blah blah. I sincerely hope at least bimatoprost will be released soon because by the time Histogen and these other treatments arrive I might be a high Norwood. If something were to come out within the next 2 years I might be able to save my hair! God willing.

01-25-2013, 07:16 AM
I once tried to use this stuff to grow my moustache, it didnt work at all.

01-26-2013, 07:10 AM
Staythick, Based on information directly from past Allergan earnings calls they said the 2 current Phase II trials (1 for women & 1 for men) would end in July 2012 and then the results would be available near the end of 2012. They also said at the time that if results were positive, Allergan would gear up for Phase III immediately. That would have put them on a pace to begin Phase III in very early 2013. In fact, they also said at the time that as soon as they "start getting any positive feedback", they would gear up for Phase III. Since Phase II took about a year, I presume Phase III could also be completed in about a year.

However, it doesn't appear that they are "gearing up" yet. They have still not released Phase II results and said in their last earnings call in 2012 that the results would not be released until sometime in 2013 and that they did not know yet whether they would go directly to Phase III or double back and do a Phase IIb......i.e. a different formulation. So its up in the air at the moment but there will be another earnings call in just over a week so we should find out more shortly.

02-06-2013, 05:27 AM
Based on Allergan's Q4 Earnings call......still no feedback on their Phase II trials:

Scott M. Whitcup - Chief Scientific Officer and Executive Vice President of Research & Development
So David, as we've stated before with the hair growth program, we had data rolling in, continuing through the end of the year and have stated that we would present those data at a conference in the second half. We haven't really commented on those data per our policy. What we've said is, if there were a dose that had great efficacy and differentiation from minoxidil, we'd go into Phase III. Should we not see that differentiation, but still see a positive signal that it was growing hair, we have the ability to increase the dose fairly substantially in a Phase IIb. So you'll get an indication of where we're at either when you see the data or if you see either a Phase III or a Phase IIb on clinicaltrials.gov, but we haven't announced anything further than that.

02-14-2013, 12:24 PM
We're havin a group buy if people are interested in using this

03-04-2013, 11:45 AM
If this thickened and darkened his existing hair and formed vellus hairs with .03% concentration then a 3% solution, which is 100 times the strength may be an incredible treatment.

02-23-2015, 03:17 AM
I've been making my own solution containing Prostaglandin the key ingredient in Bimatoprost
I'm almost at month 2, I haven't noticed my regrowth yet but it has stopped my hair loss
My existing hair does seem stronger than before

02-23-2015, 12:37 PM
Why would you post that in a two-year old topic?

02-23-2015, 12:51 PM
I only registered recently after years of spectating

02-23-2015, 12:56 PM
:rolleyes: Right- I've been spectating too but I joined in 2014 Nov, and posted today.

That still doesn't explain why would anyone post on a 2 year old topic.

02-23-2015, 01:03 PM
Crap do you think this guy tito is just out to sell stuff?

02-23-2015, 01:08 PM
Tito can you tell us exactly what is in your solution please? BIM does not equal "prostaglandin" . There are many prostaglandins, and BIM is a specific compound. Your explanations make you sound sketchy. Also the .03 concentration is not gonna do anything for people. They are currently in phase IIb trials because the 1% concentration was no better than minoxidil.

02-23-2015, 01:08 PM
Yeah that's what I exactly think- Just 12 posts, recently joined- posts on a two year old topic and says 'he' makes it himself in more than one post and also states he hasn't experienced any regrowth.

02-23-2015, 01:38 PM
Tito can you tell us exactly what is in your solution please? BIM does not equal "prostaglandin" . There are many prostaglandins, and BIM is a specific compound. Your explanations make you sound sketchy. Also the .03 concentration is not gonna do anything for people. They are currently in phase IIb trials because the 1% concentration was no better than minoxidil.

I don't remember seeing any trial results for more than .03%. Where did you get this from?

02-23-2015, 01:54 PM
Bim is a prostaglandin I never said it was prostaglandin

02-23-2015, 01:57 PM
Haven't you ever made your own ru?
Yea I haven't had any regrowth yet, I'm not eve at 2 months yet
If I was trying to promote and sell the stuff would
I really say I had no regrowth? It's hardly a mastermind marketing strategy now is it?

02-23-2015, 02:27 PM
I don't remember seeing any trial results for more than .03%. Where did you get this from?

you are correct, it's the 0.03% solution they were dissapointed with, and from searching around the internet youll see that some people still get results from that low dose(very minor though, similar to min)

no idea what to expect from a bigger solution