Aderans

[Kirby_]

Wait, I'm confused - is Aderans just the old Intercytex rebadged, and equally won't work/will never get released?!

[amibald]

If they're not using DP cells then there will not be DHT resistance! Their current treatment will probably only delay the inevitable!

Replicel, Aderans, Follica & Intercytex have all folded!

Histogen is all that's left to give us a slight regrowth before we lose it all within 5 years!!!

It's all over I think! Baldness will not be cured in this decade

We lost out!

Gho? 10char

[Artista]

"Replicel, Aderans, Follica & Intercytex have all folded!"
Based on WHAT exactly?

[Boldy]

It's all over I think! Baldness will not be cured in this decade

We lost out!

I still have hope. and know everything is possible, with the right resources and knowledge. with that I know there are other ways as an alternative, but it will take much much work, efforts and a place to do it..

BTW, lets await aderans phase 2 results, maybe the regrowth is promising.. and maybe it lasts for xx years, enough until the next sessions. its to early to tell at this point.

Don't loose your hopes yet guys..

[534623]

WTF!! - Are you serious or mimicking some of the haters?

Who are the haters? Am I a hater of novel approaches?

The guy on the left side is a normal young hairloss forums user like you. The guy on the right side is an abnormal hairloss forums user, because he always wants to know the FACTS about all these novel approaches – it’s me.
Nevertheless - both guys, as you can see in the pic, have the same problem; no matter how different they think about novel approaches. That means, BOTH would warmly greet such novel approaches; provided, their products work as promised.

You have to understand, that not every person out there in general or on hairloss forums is as “blue-eyed” than the other – bald or not. Sometimes they are not even interested to know WHEN something will hit the market; at first they are more interested about the WHETHER – whether or not something is working at all or whether or not there are any risks involved. Or whether or not something has at least the potential to work at all – before they get (over-)excited.

Anyway, as you can see, my tonsure area, for example, is still not slick bald per se; there are still lots of just miniaturized hairs.
So don’t you think that I too would rather WARMLY greet something like Aderans’ (new) “rejuvenation of existing hair follicles structures” idea, instead of doing (costly) hair transplants, to fill up all the bald areas with permanent und healthy terminal hairs producing follicles again?

So the question remains: do I believe in ARI’s old/new idea/approach?

Should I believe in ARI’s new idea? If YES, why? What are the FACTS?
Should I simply wait, instead of doing any hair transplants?
To avoid any loss of time, I have to find out IN ADVANCE whether or not something like ARI’s approach has at least the potential to work at all – in advance! That’s the point. At least, my standpoint.

[Kirby_]

BTW, lets await aderans phase 2 results, maybe the regrowth is promising.. and maybe it lasts for xx years, enough until the next sessions. its to early to tell at this point.

Don't loose your hopes yet guys..

I suppose objectively, ANY new super-treatment or procedure, should it reach the market should be warmly welcomed... I think many of us forget how little means we have to treat hairloss effectively.

[StinkySmurf]

Before I explain the "rejuvenation thingy" problems again

Ok, I did my part so lets hear the rejuvenation thingy. What makes you think ARI doesn't have a marketable product?

[Artista]

Desmond, I have to ask again..

"Replicel, Aderans, Follica & Intercytex have all folded!"
"It's all over I think! Baldness will not be cured in this decade"
Based upon WHAT exactly Desmond?

[StinkySmurf]

It's not out of the realm of possibility that Aderans could turn it's last study (Phase 3) that should start early 2013 into a 6-month study.[/I]

Hey Desmond, I've been fishing a little, and it seems the final trial will be a different length. I also heard it will be six months instead of 12, but it's not clear if it will be Phase 3 or not. People tend to clam up when you use words like Phase.

I also heard it could be a different baldness pattern, but it's not clear if that was similar to other routine changes between trial criteria or if it was a major difference.

I'm just wondering if you folks think they would do a final 6 month Phase 2 trial that covers everyone before they move into Phase 3?

[534623]

"The problem with the hair patch assay was it was not very translatable to the human condition, and early on we spent a lot of time looking at developing architecture that... err scaffolding... that we can put our cells in to try to orient the growth of hair follicles because despite all of the success that we are so proud of this is of limited utility in an aesthetic environment."

So there you go. They went with an approach they could make it through Phase 3 with on a $150 million dollar budget instead of going for something so complex as creating a follicle with a scaffolding because that involves aesthetic issues like the angle of hair growth that are an order of magnitude more difficult and these are not folks that want to go outside the company for money. This is a slightly down on it's luck $500 million dollar company where the majority of shares are held by just three parties, and lets face it, they don't want to go after the market of people that are willing to have surgery... thats the whole point of the opening chart where they say they want to be the botox of hair. In other words, they want to reach economies of scale. They are not looking for a solution that involves needing a bunch of artist grade plastic surgeons. They're looking for something thats mass market at least initially.

Thanks Stinky Smurf, really great. THAT’s what I wanted to hear – concerning ARI’s former “brand new hair follicles from scratch” approach.

Okay, now it’s time talk about ARI’s new approach (basically similar to the other approach), and what Dr. Washenik is saying in the video concerning the new “Morphogenic Switch” approach …

http://youtu.be/l_JHbtXJ0a8

05:55>>>“This system will only work in people …”

So WHAT EXACTLY is he saying about this approach (which they intend to bring on the market)?
Can you please complete my quote/sentence above? What exactly is he saying? Can you help me please to find out whether or not this shit will work for me?

[StinkySmurf]

So WHAT EXACTLY is he saying about this approach (which they intend to bring on the market)?
Can you please complete my quote/sentence above? What exactly is he saying? Can you help me please to find out whether or not this shit will work for me?

"And so this system will only work in people who have atrophic or miniaturized hair follicles... like in male pattern and female pattern... uhh... alopecia or hair loss or androgenetic allopecia... and the way we were able to pin down that mechanism is by injecting these male cells into that skin model..."

[534623]

"And so this system will only work in people who have atrophic or miniaturized hair follicles... like in male pattern and female pattern... uhh... alopecia or hair loss or androgenetic allopecia... and the way we were able to pin down that mechanism is by injecting these male cells into that skin model..."

Right, thanks.
And what exactly is he saying in this scene ...

"We injected the whole area (blue circle in the pic) after injecting cells just into the 4 sample injection sites." - or something. Results?
Then he is saying ...
"Those follicles who have been miniaturized for the shortest period of time and which are most receptive (prone to) for such kinds of approaches …" - or something, right?
Then he is saying something about skin samples from the trail subjects BEFORE they get cell-injections, to determine, whether or not a trail subject will be responsive for the treatment at all - right?
Does it mean they are doing this to "manipulate" the final trail results? I mean, does it make sense doing such pre-testing? I mean, of course they will get better results, when they just inject just those trail subjects, which are still "receptive" for such treatments - right? wtf...

[534623]

Then he is saying something about skin samples from the trail subjects BEFORE they get cell-injections, to determine, whether or not a trail subject will be responsive for the treatment at all - right?
Does it mean they are doing this to "manipulate" the final trail results? I mean, does it make sense doing such pre-testing? I mean, of course they will get better results, when they just inject just those trail subjects, which are still "receptive" for such treatments - right? wtf...

Wow - IF I'm not completely wrong, the following (same) will happen as soon as this thingy is on the market ...

Dr. Cole wrote recently in another hairloss forum (in another context)...
**************************************
Here we go again with the argument about the advantage of adipose (fat) on the FUE grafts. This argument is as old at the one where novices like you tell us that patients need a FOX test first to see if they are candidates for FUE. We dispelled that theory in early 2003, yet you kept reporting that patients needed one. The Fox test was never necessary, but those who did not know how to do FUE needed a way to lure patients into their office for a FUE procedure. Then after the patient came in, the patient would have a FOX test that would show the follicle transection rate was too high so the patient would be told he needed a strip procedure. How do I know this happened? I had plenty of patients come to my office for a FUE procedure that had failed their FOX test, but they did not like the alternative – a strip procedure – so they came to see me. I did an FUE procedure on these patients with no problem.
**************************************

Do you guys understand what I mean/predict with that?
Perhaps this is just a paranoia - but I doubt I have paranoia...

[StinkySmurf]

Those follicles who have been miniaturized for the shortest period of time and which are most receptive (prone to) for such kinds of approaches …

"here later you can see the increase in hair follicles and obviously... countable... if you think of the balding circle... this is the edge of the balding circle so there are more hair follicles here whereas here towards the center fewer hair follicles... and you can see here the ability of these cells to turn on hair follicles that had been miniaturized and had been over time reduced, over and over, the length and duration of their anagen cycle"

[StinkySmurf]

We injected the whole area (blue circle in the pic) after injecting cells just into the 4 sample injection sites.

Later we started injecting this whole balding area after we would inject the four square centimeters that we were gonna track with macrophotography.