Replicel

[Maradona]

Hmmmmm. I don't post often on forums. I think I will now, because like so many, I'm excited to see replicels results.

Firstly, though it's only phase 1, if they dont have new terminal hairs in the injection area...FAIL. It being a cell based treatment means they can only increase the number of the cells hey inject, there is not much else to play with here.

Second, in an email to me a while back they said they can not reveal full details as to why they believe DSC cells are the key, because it is privileged info. So, we don't know the full story.

Third (and this is my naive non-scientific thought), the location of DSC cells makes sense. They claim the DSC cells can create progenitor and other cells. It would make sense that the cells cluster and create a follicle from the bottom up.

Johada and GHO state that the DS tissue containing stem cells can create a new follicle (proven). But culturing to increase their numbers is hard. And a reduction in the number of stem cells reduces hair quality. Replicel say that all other cells are more mature types, that can not be multiplied many times, which is where the DSC ones differ. DP cells migrate away from the follicle in balding men, so they were never the answer, which is widely accepted now.

If DSC cells the key, the big question is if there is something in balding scalps that will prevent injected cells being used. But then, transplanted follicles grow in slick bald scalps. If the "environment' was screwed, those transplants wouldnt work and be lasting.

Cells do migrate and recruit. So at the very least, I believe they will revive sleeping follicles.

Obviously im no expert, but I think its reasonable to be hopeful of replicel.

You are a very smart guy.

[NeedHairASAP]

so is this a end all cure like 2020 says? or is it a hair transplant supplement as others are saying?

[gmonasco]

so is this a end all cure like 2020 says? or is it a hair transplant supplement as others are saying?

As of yet, it's neither.

[Pate]

I think there is a language barrier here. Are you saying that you believe hair follicles can irreversibly "die" or that they can be revived? This study seems to indicate that they can be revived, but it doesn't really go into a lot of detail about for how long those hairs were minituraized.

Is there a doctor in the house?

I am still trying to find that out as well. I have read that the follicles do in fact die eventually - by slick bald NW7 stage. The mechanism by which this supposedly happens is that body tissue actually grows through the follicles, destroys their structural integrity and basically reabsorbs them into the skin.

But I have never been able to find that source again, or any other source saying the same thing.

Krewel is of course right that it's been shown DAMAGED follicles can regenerate, and possibly even follicles so damaged they are not producing any hair.

But whether those damaged follicles can ever go past the "point of no return" and die, I still haven't been able to get a straight answer. I suspect the work has been done and probably published because it shouldn't be too difficult to prove the tissue regrowth theory - take a biopsy from a NW7 who's been balding since his teens and examine the structural integrity of the follicles under a microscope.

But it would take somebody with a better grasp of the medical literature than myself to find it. Or at least some better google-fu.

[UK Boy]

Pre results interiew??

I thought Spencer was going to get an interview with David Hall before the results were released. It's the 16th today so I woulda thought around this time would be ideal for his pre results interview. Replicel said end of April for results and I would consider any time from next monday (23/04/12) to be 'End of April'.

So Spencer or Joe if you're reading this, "When are we getting this interview?" Or are we not gonna get one now?

[clandestine]

I think the majority feel a pre-results interview would be unnecessary. [Myself included].

[BoSox]

I agree, we're almost at the end of the month. We will know if they have the cure for baldness within the next 2 weeks, might as well wait.

[gmonasco]

We will know if they have the cure for baldness within the next 2 weeks

Umm, probably not. Likely all we'll know is whether they have something that merits further testing.

[Follicle Death Row]

Umm, probably not. Likely all we'll know is whether they have something that merits further testing.

Yeah. All we'll know is if they have anything that merits further testing but for sure they'll have a much better idea since they're testing extremely high numbers of cells. I expect them to keep a lot of info to themselves. The field of non-surgical treatments seems to move at a snail's pace so I'm not expecting anything big but I wouldn't mind being pleasantly surprised.

[PvH]

if a company plans on revealing a major breakthrough my guess is that we'll first learn about it on all major tv news outlet. you'd have to be living under a rock to not know that a cure is coming. i'm not expecting any groundbreaking information to come out of the TBT interview.

[sausage]

No point in an interview before. They aren't going to tell you anything about how the trial went. Seriously what do you guys need to know a week before the results?

We should have all the info we need next week when they tell us their good or bad news.

[lpenergy]

Trial announcement

Ok folks. Do you want to know when release date will be for the trial? I can pretty much guarantee that it will not be released after the 2011 Annual Earnings report which was dated/released on April 29th last year. In fact, the two may timed together this year and this could have been the source for the short "delay". I am quite confident that the trial information is going to be included in the MD&A in some form or fashion-I would be shocked if it wasn't considering the prior MD&A discussions. They could release the trial results prior to the financials, but probably not afterwards.

I am going to send investor relations a request for the release date of the financials. Last year, they were dated/released on April 29th, which was a Friday. This year, it could be either on the 27th or 30th. My guess is for the 30th.

Hey, it looks like there was a buyer of 10,000 shares.

[Sogeking]

Umm, probably not. Likely all we'll know is whether they have something that merits further testing.

I think that they will most likely continue to phase II trials. However that will tell us nothing.
If everyone remembers correctly Intercytex failed in their phase II trials concerning efficacy despite their phase I trials being excellent.

I am much interested in the end of phase II trials for Histogen and Aderans. I think Replicel results will be a formality. Although I would hope they put pictures and some info like Histogen did in their phase I trials.

[sausage]

Hey, it looks like there was a buyer of 10,000 shares.

Someones either crazy or knows something.

[534623]

I think Replicel results will be a formality.

i think you are right. but the question is for which non-fda authority.