Replicel

[clandestine]

Yes, it's ridiculous. People can't even imagine how complicated alopecia and the hair follicle as an organ itself is.

If we're able to start growing organs etc. from scratch, I'm sure hair follicles can't be all that more complicated.

https://www.youtube.com/watch?v=lfqxbwbjw00

Lung^

[greatjob!]

If we're able to start growing organs etc. from scratch, I'm sure hair follicles can't be all that more complicated.

https://www.youtube.com/watch?v=lfqxbwbjw00

Lung^

Yes but a lung doesn't fall off and regenerate itself every few months....

[TrueGround]

I just quoted my own reply. Just because it seems to me that is one of the most sense replys about Replicel, and no one noticed it. Or maybe i´m just stupid.

I think that is one of the most sensible of the positive replies I've seen to this situation as well. It's exactly my thought process and how I wanted to respond to the results, but I couldn't think of how to put it into words at that moment, got busy, and said screw it after all the overwhelming bashing started pouring in.

I never jumped the Replicel ship, even after being disappointed in not seeing crazy regrowth. But after I washed away my sorrows with a couple ****tails and shrugged it off the next day, it almost started to make sense that there wasn't much regrowth at 6 months.

For instance, posters here have been referring to Histogen as possibly being "Minox on steroids" - coaxing follicles out of telogen phase into anagen via a potent dose of growth factors. However, Replicel took the approach of addressing the issue at a very early step in follicle genesis (as I understand it) with replicated ("brand new") DSC cells - at least one, if not several steps before Histogen's growth factor approach even comes into play. Essentially, the treatment is restarting from scratch or close to it. It only seems to make sense that it will take significant time for brand new follicle genesis, for that follicle to go through multiple "cycles" or processes we may not be aware of and then to be capable of generating a terminal hair (like in a baby's scalp^). It could also make sense that any vellous hair follicles would take considerable time to recruit DSC cells and tare down/rebuild, where as Histogen's growth factors are immediately, and unnaturally available - thus the hasty new or "coaxed" hair growth.

The above has been theorized with very little bio knowledge. But shit man, they grew hair on mice ears and feet! Plus D. Hall said a mouse's biological processes cycle much faster than a human's. I know they were mice, but it was approached at the cellular level. I don't see why it shouldn't work in humans once the (seemingly many) kinks are worked out.

I'm over being pissed about the prelim efficacy. I'd just be legitimately surprised if Replicel doesn't develop into SOMETHING viable, whatever those results might entail.

[Maradona]

I think that is one of the most sensible of the positive replies I've seen to this situation as well. It's exactly my thought process and how I wanted to respond to the results, but I couldn't think of how to put it into words at that moment, got busy, and said screw it after all the overwhelming bashing started pouring in.

I never jumped the Replicel ship, even after being disappointed in not seeing crazy regrowth. But after I washed away my sorrows with a couple ****tails and shrugged it off the next day, it almost started to make sense that there wasn't much regrowth at 6 months.

For instance, posters here have been referring to Histogen as possibly being "Minox on steroids" - coaxing follicles out of telogen phase into anagen via a potent dose of growth factors. However, Replicel took the approach of addressing the issue at a very early step in follicle genesis (as I understand it) with replicated ("brand new") DSC cells - at least one, if not several steps before Histogen's growth factor approach even comes into play. Essentially, the treatment is restarting from scratch or close to it. It only seems to make sense that it will take significant time for brand new follicle genesis, for that follicle to go through multiple "cycles" or processes we may not be aware of and then to be capable of generating a terminal hair (like in a baby's scalp^). It could also make sense that any vellous hair follicles would take considerable time to recruit DSC cells and tare down/rebuild, where as Histogen's growth factors are immediately, and unnaturally available - thus the hasty new or "coaxed" hair growth.

The above has been theorized with very little bio knowledge. But shit man, they grew hair on mice ears and feet! Plus D. Hall said a mouse's biological processes cycle much faster than a human's. I know they were mice, but it was approached at the cellular level. I don't see why it shouldn't work in humans once the (seemingly many) kinks are worked out.

I'm over being pissed about the prelim efficacy. I'd just be legitimately surprised if Replicel doesn't develop into SOMETHING viable, whatever those results might entail.

You guys are tripping ! Replicel doesn't have a good record and even if these results were true, who the hell needs microscopic hairs and unnoticeable increased density which are not even consistent on all patients.

Growing hair a mouse feet? Replicel's not the only one who has done it, all HM companies can do it. Replicel used their "patented" procedure consisting of DSC cells and DP cells, the latter used by ARI, and they got the exact same result on mouses feet.

The results were also the same in mouse's ear but the only difference is that the DSC cells did not cluster. This is the reason why replicel was born, they thought these DSC cells were the progenitor cells capable of regenerating the entire hair structure even affecting the AGA tissue around it for it's survival but it has FAILED to produce what they thought it could do.

This is all ADERANS all over again and aderans has solved the clustering problem with some tweaks.

Aderans is way ahead of replicel and want to market their procedure and they are trying to cure advanced stage pattern baldness.

Replicel's just trying to impress investors by growing some stuff on thinning areas to get some good results, sell their stuff and get paid. Wether they come to market or not, they do not care.

However all these companies will not cure MPB, they are not solving the root of the problem but simply prolonging the inevitable and for how long? apparently not enough to market it.

You guys need a reality check. Don't get me wrong I want this shit to be cured I am in no treatment whatsover but nothing is impressive so far.

Histogen results are somewhat impressive and lets hope they can last.

[BoSox]

Aderans is way ahead of replicel and want to market their procedure and they are trying to cure advanced stage pattern baldness.

What's a realistic release date for Aderans?

[krewel]

If we're able to start growing organs etc. from scratch, I'm sure hair follicles can't be all that more complicated.

https://www.youtube.com/watch?v=lfqxbwbjw00

Lung^

Well, the hair follicle is an organ and there were enough interviews were scientists that said cloning a follicle would be almost as complex as cloning a kidney. Only because it's small it doesn't mean it's easy to understand. Unless you're a biological/medical scientist, trust me, you could kind of say it's beyond our understanding.

[67mph]

...Damn it!

Positivity didn't last long eh ...they're back!!

Once the threads get bumped, the 'know-it-alls' (minus the lab coats i notice??!) come crawling over for a sniff around.

This is a Replicel thread, Rep-li-cel.

Now go and fill in some wikipedia pages yeah.

[JJJJrS]

...Damn it!

Positivity didn't last long eh ...they're back!!

Once the threads get bumped, the 'know-it-alls' (minus the lab coats i notice??!) come crawling over for a sniff around.

This is a Replicel thread, Rep-li-cel.

Now go and fill in some wikipedia pages yeah.

I don't understand this mentality on here. Why does everyone have to be "positive" about Replicel? Is this a cult where everybody has to think the same and blindly believe, with little evidence, that every one of these treatments in development will work?

We all want to see Replicel succeed and baldness to be cured. But we also have to be objective. Setting unrealistic goals and getting your hopes up only to be disappointed in the end isn't the best thing to do either.

Replicel didn't exactly behave in the most responsible manner with the paid advertisements themselves. What matters most in the end though is what Replicel does, not what posters on here say.

I know baldness is difficult to deal with but some of you should show a little more emotional maturity. If you strongly believe in Replicel then you shouldn't be bothered if some people show skepticism, which is a normal reaction.

[Follicle Death Row]

What's a realistic release date for Aderans?

If it's anything like other trials I'm thinking 2017. 5 years off.

Sure that's just speculating. I don't know how long it will take Aderans to get the infrastructure in place and how long a phase 3 trial they intend to run. It's complete guess work at this point but 2017 seems reasonable if they really are to wrap up phase 2 towards the end of this year or early next.

[UK_]

What's a realistic release date for Aderans?

id probably say 6780.

[67mph]

I'm a glass half full type a fella as much as possible, where possible.

I just don't like to drink with the half empty type'a guys that's all.

[Horseshoe]

Stock crash

Has anyone seen how low the Replicel stock has fallen. It closed today at $1.21 If it keeps dropping like this not sure where the funding will be to forge ahead.
How disconcerting...

[Davey Jones]

Has anyone seen how low the Replicel stock has fallen. It closed today at $1.21 If it keeps dropping like this not sure where the funding will be to forge ahead.
How disconcerting...

If my understanding is accurate, that is not where their funding comes from. They sell stocks initially (and take private funding) to gain capital. Past that, the changes in stock prices only really affects individuals who hold stock. To be fair, that is probably in good part some of the higher ups at Replicel, but the company itself is not funded based around rising and falling stock prices.

Again, if my understanding is accurate, they have at least enough funding to finish their Phase II already lined up.

[Horseshoe]

If my understanding is accurate, that is not where their funding comes from. They sell stocks initially (and take private funding) to gain capital. Past that, the changes in stock prices only really affects individuals who hold stock. To be fair, that is probably in good part some of the higher ups at Replicel, but the company itself is not funded based around rising and falling stock prices.

Again, if my understanding is accurate, they have at least enough funding to finish their Phase II already lined up.

Thanks for the clarification. In the end I've lost my hair my money and all hope of escaping this NW7 prison.

[Sogeking]

I know I'm a woman and this is mostly a male oriented forum, but I wanna give my 2 cents.

I think that this announcement was made in order to make people realize that the previous results released were not all that bad. Of course some people will still think these are bad news, and I get it, 'cause we're all desperate for a cure (I should know, I'm a 23 year old woman with thinning hair, it's devastating)... but I still have faith in Replicel... I think they're on the right track and as has been noted before, these things take A LOT of time. These are new treatments, there's no background to compare them to, so results will vay a lot from time to time. I think that even if Replicel can't grow a lot of hair, if they can somehow make existing follicles immune to hair loss, that would be awesome! Sadly with science and new treatments it's all about trial and error and that takes time... I always remember that famous quote by Edison:

"I have not failed. I have just found 10,000 ways that don't work".

And that's the way it is... but in any case I'm grateful thatt there are people working on this, and I think at least one out of the four main companies working on this will succeed. Maybe next year, maybe 5 years from now, maybe in 10 years... but some day, someone will make it. I know we all want a cure NOW - when I look in the mirror sometimes I feel very angry that there's still no way to fix such a fundamental part of my image... but I'm sure there will be a cure.

You know what would have been bad results, anyway? If this had somehow encouraged hair loss. Maybe I'm too optimistic or naive, but I'm one of the people who think that 6 months is still to early to judge Replicel's efficacy.

Welcome to the forum mimosa .
I feel the same way as you do. Hey if in 1 year post op they get 20-30% regrowth or increase in total hair than they mightbe on something.

But the guys at REplicel themselves have stated thay would deem their treatment successful if they get more than 15% regrowth...
We'll wait and see I guess...
Its frustrating but who knows...