In terms of facial aesthetics and the reduction of lines/wrinkles the following cosmeceuticals, usually applied as a serum before you moisturise have the best evidence base.
1. Retinoids (including retinol and retinoic acid), which are Vitamin A compounds.
2. Hyaluronic acid
3. Peptides
4. Vitamin C
5. Niacinamide
This is my opinion based on trials and what has worked for me. I must stress that I am not a physician so please do your own research. Patch test should be used for retinol products as they can cause irritation so build up with concentrations and number of times applied PM per week.
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