Replicel Sets The Record Straight

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  • PinotQ
    Senior Member
    • May 2010
    • 188

    #31
    Originally posted by PinotQ
    Great update and any progress is encouraging. But one line of questioning I would like to see on the next interview would be a more detailed focus on the method of culturing. My understanding is that the major problem with culturing and re-injecting cells is that cultured cells lose their inductivity with each pass in culture. As many of you may recall, Aaron Gardener, who worked with one of the various research teams, said on this forum over a year ago that their team had only succeeded in reaching 60% inductivity (retaining 60% of their cellular characteristics) and that was with dermal papillae cells. He had also mentioned that no one at the time had succeeded in having any sort of success rate in culturing dermal sheath cup cells (no inductivity). Since that time, a greater degree of success has been reported in culturing cells with something called 3 dimensional culturing. Personally, I think the whole key lies in attaining a method of culturing that retains all of the cell's characteristics each time they are multiplied in culture. I would be curious as to Replicel's thoughts on this subject.
    It was actually 40%. Here is the thread: https://www.baldtruthtalk.com/thread...-Gardner/page7

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    • Thinning87
      Senior Member
      • Dec 2012
      • 847

      #32
      Originally posted by PinotQ
      Great update and any progress is encouraging. But one line of questioning I would like to see on the next interview would be a more detailed focus on the method of culturing. My understanding is that the major problem with culturing and re-injecting cells is that cultured cells lose their inductivity with each pass in culture. As many of you may recall, Aaron Gardener, who worked with one of the various research teams, said on this forum over a year ago that their team had only succeeded in reaching 60% inductivity (retaining 60% of their cellular characteristics) and that was with dermal papillae cells. He had also mentioned that no one at the time had succeeded in having any sort of success rate in culturing dermal sheath cup cells (no inductivity). Since that time, a greater degree of success has been reported in culturing cells with something called 3 dimensional culturing. Personally, I think the whole key lies in attaining a method of culturing that retains all of the cell's characteristics each time they are multiplied in culture. I would be curious as to Replicel's thoughts on this subject.
      I think you are spot on. But I easily could be wrong.

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      • k9gatton
        Senior Member
        • Oct 2016
        • 570

        #33
        Originally posted by Hubris
        Replicel is the better alternative to Propecia, yes. Minoxidil could still be used in conjunction with Histogen so I would not technically call it an alternative. Theoretically, in the future a person could utilize Replicel, Histogen, Minoxidil, Bimatoprost, SM04554 and Piloscopy. In fact, if just one of those products currently in clinical trials comes to market, it is a game changer for many of us.
        Histogen only lasts for one complete hair growth cycle. After two to six years, time for more injections. That said, I personally believe that people who respond well to Minoxidil will benefit from Histogen. I'm going to try it, as soon as it comes to the US. As an older guy, I really appreciate the fact they're targeting an older audience. That goes far in my book.

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        • skyguy
          Member
          • Nov 2016
          • 48

          #34
          UPDATE
          the data and photos from shiseido trial will be published in 2018 not before that
          Click image for larger version

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          sry for the bad quality of photo i don't know y it's happening
          Last edited by skyguy; 12-17-2016, 01:18 PM. Reason: image quality is low

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          • long4hair
            Member
            • Nov 2016
            • 76

            #35
            Originally posted by skyguy
            UPDATE
            the data and photos from shiseido trial will be published in 2018 not before that
            [ATTACH=CONFIG]50042[/ATTACH]

            sry for the bad quality of photo i don't know y it's happening
            What does it say? It's too small for me to read it.

            Comment

            • k9gatton
              Senior Member
              • Oct 2016
              • 570

              #36
              Originally posted by long4hair
              What does it say? It's too small for me to read it.
              They won't have any photos until 2018, if completed.

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              • k9gatton
                Senior Member
                • Oct 2016
                • 570

                #37
                Originally posted by jamesst11
                That is apples and oranges my friend. These technologies differ so drastically in how they affect you at the cellular and molecular level that it's pointless to even compare. In my opinion, finasteride is primative as hell compared to what histogen and replicel are trying to accomplish. Finasteride is like shooting a slingshot at an elephant, while Histogen's protocol, if it truly is what they say it is, is targeting it with a high power sniper rifle. F*ck finasteride and f*ck minoxidil, seriously. I am not saying this out of bitterness as both of these have offered something to me... but they are PRIMATIVE AND WE NEED BETTER ALTERNATIVES.
                We do. But we can only use what is available. If it doesn't have proof, we are just wasting our time.

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                • baldingdawg
                  Junior Member
                  • Oct 2014
                  • 7

                  #38
                  Hey k9gatton,
                  when do you expect Histogen to enter the market?

                  Comment

                  • skyguy
                    Member
                    • Nov 2016
                    • 48

                    #39
                    Replicel sets their goals in 2017
                    they said they will also release 12 month and 24 month mark results in first quarter of 2017 from their phase 1 trial
                    the link below discusses about their 6 month's result of phase 1 and it was not bad because Average hair density increase was 14.3% and max hair density increase was close to 20% and this was just at 6 month mark unlike the fin and minox which acquired this gain at 12th month mark
                    u can get this info on page 22

                    Comment

                    • skyguy
                      Member
                      • Nov 2016
                      • 48

                      #40
                      will update u guys when i have further info.

                      Comment

                      • Kashman
                        Member
                        • Jan 2017
                        • 35

                        #41
                        I became very hopeful when Shiseido entered the game.

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                        • allTheGoodNamesAreTaken
                          Senior Member
                          • Aug 2015
                          • 342

                          #42
                          Always dangerous to be very hopeful. Cautious optimism at most.

                          Comment

                          • skyguy
                            Member
                            • Nov 2016
                            • 48

                            #43
                            21st Act Cures will give a boost to the development of cell therapies for sure



                            this act would definitely help the hairloss industry ( there's no doubt left in this now)

                            Out of the spotlight of the more prominent provisions of the Act, is a section pertaining to what I predict will be a growing but eventually radical boost to the development of regenerative medicines such as “cell therapy, therapeutic tissue engineering products, human cell and tissue products, and combination products using any such therapies or products”.


                            So in short, these treatments won't have to go through phase 3 trial for approval.
                            and the waiting game is finally coming to an end

                            will update when i have further info.

                            Comment

                            • mrclean
                              Senior Member
                              • Jan 2017
                              • 524

                              #44
                              I would think there be some news by now if they are going to be accepting customers in a few months? Shiseido just tells you to check the web site and won't give any other information.

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