CHINA : the stem cells paradise?

[lacazette]

As we see here China represent 22% of all the results of regenerative medicine humans clinical studies from 2014

http://celltrials.info/2015/03/01/results-regenmed-studies-2014/

"The biggest number of reports came from China. US was the second biggest contributor. I summarized major contributing countries (more than 4 reports) in this figure:"

China 26
US 14
India 8
S.Korea, France 6
Japan,Spain,UK 4


Now I see that there's already several medical center in china who are using/testing stem cells therapies for serious diseases, with patients that come from all over the world:

http://www.chinastemcell.com.cn/

http://stemcelltreatmentnow.com/about-us/

There's a looot of patients in every disease category. With case analysis, patient's stories, and the treatment given, it's really interesting
And it looks like the results are good

[lacazette]

"According to the U.S. National Institutes of Health there were 164 stem cell clinical trials taking place in China during 2014"

The China FDA give two type of autorisations:

'authorisation to companies running clinical trials using stem cells that are intended to become commercial stem cell therapies'

'authorisation of individual stem cell procedures on a patient-by-patient basis under a high-risk medical technology classification

"New regulations (2015) require that patients receiving stem-cell transplants continue to be observed after the trials are over to ensure the long-term safety and effectiveness of the trial research
Stem-cell researchers are required to halt a trial immediately after adverse reactions are observed and trial participants would have to be informed before the trial of the goals and risks of the treatment.

"It remains to be seen whether implementation of the new regulation will simplify and expedite the approval of stem cell trials and whether China will remain a prime destination for international companies to conduct such trials"

[FooFighter]

Stem cells therapies in China, India and Latin American countries are not safe at all, because expect few big cities in those countries everything else is very poor and a lot of population is illiterate. They will do everything to take your money, because you are desperate to try everything even you are not sure that is safe at all. Europe, North America, Australia, New Zeland, Japan, South Korea, Singapore have very strong regulatory laws about safety therapies.

[lacazette]

Of course it can not be 'safe' as there's no long term background for stem cell therapies. So we don't know if all these patients will have a cancer or not. But what we see here is that stem cell therapies seems to be working and helpful for various serious diseases

those patients are in the category : authorisation of individual stem cell procedures on a patient-by-patient basis

So they are considered as a human trial, they know the risk. So it's the same as the people who enter a US clinical trial for stem cell therapy

[lacazette]

Stem cells therapies in China, India and Latin American countries are not safe at all, because expect few big cities in those countries everything else is very poor and a lot of population is illiterate. They will do everything to take your money, because you are desperate to try everything even you are not sure that is safe at all. Europe, North America, Australia, New Zeland, Japan, South Korea, Singapore have very strong regulatory laws about safety therapies.

the first center was funded in 2000 by two Beijing universities and the Beijing Unit Wealth Company. After 8 years of collaboration the center launched several state level projects and gained support from national government. Based on the research results, they use stem cells for clinical treatment

http://www.chinastemcell.com.cn/en/About-Us/72013122974.html

We don't talk here about a crazy anonymous doctor or whatever

And 99% of their patients comes from all over the world, so you're out of the subject when you said "everything else is very poor and a lot of population is illiterate,.."

[Renee]

Nothing for hair.

[lacazette]

Renee it's medical research backed by government, it's normal that they focus on serious diseases, that lack of good solutions.
those many patients can have individual china FDA authorisation for stem cell therapy, but because it's serious and not cosmetic problem.

But it's really nice to see that these many patients were treated with a stem cell treatment, and that it seems to work good. It's a good sign for hair in near future

China seems to be the leader for the moment in stem cells trials research, so there could be hair related clinical trials already that we don't know

China's governement do the same as USA, with differents research institutes, medical, universities, companies that collaborate under the flag of national research

and there is research related to hair like here for exemple May 2015:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447420/

"We conclude that miR22 is a critical post-transcriptional regulator of the hair cycle and may represent a novel target of therapeutic modulation of hair growth"

they used wounded neogenesis in the study to better understand the miR22 mechanism, etc


I see also the stem cell educator therapy that reverse a full AA and comes from different researchers of China universities

[Renee]

Baldness is a huge problem in china, kind of like japan.

[hellouser]

Baldness is a huge problem in china, kind of like japan.

Too bad everyone in China is too poor to even afford basic finasteride.

[joachim]

Baldness is a huge problem in china, kind of like japan.

that's true actually. it's interesting that they haven't come up with a hair loss solution meanwhile. they have much more man-power than other countries and are especially eager normally, also they are able to take more unconventional and faster routes to test new stuff.

however, it's almost end of 2015 and we have absolutely nothing useful for hairloss. it drives me crazy sometimes.

[Renee]

I remember when dr. Xu & dr. Cotsraelis converted ips cells to epithelial cells in 2014 many forum members said the final step was to make dermal papilla cells from ips cells. Fast forward to 2015, dr terskikh & sanford burnham researchers used ips cells to make dermal papilla. My question is using these 2 components can't they grow hair follicles in a dish and have a surgeon implant them one by one? This would be a full blown cure nw7 to nw1.

[Renee]

I'm sure research and maybe even trials are going on in china that we don't know about. Chinese people are very secretive, don't like to disclose much info until they are 100%.

[joachim]

I remember when dr. Xu & dr. Cotsraelis converted ips cells to epithelial cells in 2014 many forum members said the final step was to make dermal papilla cells from ips cells. Fast forward to 2015, dr terskikh & sanford burnham researchers used ips cells to make dermal papilla. My question is using these 2 components can't they grow hair follicles in a dish and have a surgeon implant them one by one? This would be a full blown cure nw7 to nw1.

you're right. what the sanford-burham guys achieved is huge so far. the only setback is, that they mentioned, the iPS conversion to DP cells is not yet very efficient. something like 2 or 3% of the iPS cells are successfully converted and rest of it is trash. so in theory, with those 2 or 3% they could already make a proof of concept in human scalps, and i guess this is what they are planning within the next 2 years, especially now after they received a huge funding. so the low efficiency would mean they have to produce much more iPS cells (which is no problem) but i think low efficiency means more work and more culturing time in the lab and therefore much higher cost, for now.
if they find a way to get some automation into the game then even the low efficiency doesn't have to be a show-stopper. but of course they are probably going to try increase the efficiency first before they inject that stuff into human scalps.

it would really make sense for them to just do the proof of concept with some volunteers, to see if those from iPS created DP cells, which grew lot of hairs in mice with human grafted skin, also work in real scalps. after that they could concentrate on efficiency issues.

however, i think the sanford-burham research is the most promising so far. lauster and jahoda won't show any more progress, i think. they don't have a focus on curing hairloss. jahoda is just tinkering around in his lab and tries some funny experiments with DP cells, and lauster's team has its focus more on lab-on-a-chip technology (to replace cosmetic tests on animals). hair culturing or even a full hairloss cure has no priority for them. i don't expect anything from them anymore. even if dr. beren atac attends the congress in miami, it will be no revolutionizing news. she will just show some fancy powerpoint slides again, and mention that they have a lot more work to do.

[Renee]

Dr terskikh said the next step is to test it in humans. Let's see.

[FooFighter]

the first center was funded in 2000 by two Beijing universities and the Beijing Unit Wealth Company. After 8 years of collaboration the center launched several state level projects and gained support from national government. Based on the research results, they use stem cells for clinical treatment

http://www.chinastemcell.com.cn/en/About-Us/72013122974.html

We don't talk here about a crazy anonymous doctor or whatever

And 99% of their patients comes from all over the world, so you're out of the subject when you said "everything else is very poor and a lot of population is illiterate,.."

China have 1,35 billion population, so of course they will have a lot of good universities and very educated people, but on whole country level they are still very behind from Japan, Korea or Singapore.

Scientists claims everything, but they still didnt give us a good proof that stem cells will give significant results in humans. Stem cells therapies are still science fiction.