Dermarolling Community Trial
As a result of the recent dermarolling study (found here and discussed here), a crossforum trial has been proposed to attempt to emulate and enhance the results of the study. Members of the private forums and public forums are free to join in and the results will be made public on every forum, regardless of participation. If you are interested in participating, please let me know.
Participation minimally requires a 1.5mm dermaroller and an agreement to take monthly photos. You may have any current treatment regimen, but before joining the trial you must provide your detailed regimen. Participation does not require a membership to any private forum.
You will be given detailed instructions on how to use the dermaroller including how often, pressure, time for injury and ideal model of roller according to one of the researchers on the study who has been contacted.
The trial groups will be as follows:
A. Dermarolling + Minox (Study Control)
B. Dermarolling + PGE2 Daily + Minox
C. Dermarolling + PGE2 Daily + minox + PGD2 inhibitor (OC-Ethanol higher dose than previously used)
Within the PGE2 and PGD2 inhibitors use will be various concentrations. Each group was designed based on past studies demonstrating the role of PGE2, FGF9 and PGD2 in wounding induced neogenesis. For those unfamiliar, the team behind Follica have demonstrated that elevated levels of PGD2 inhibit the promotive effects of wounding and that the overexpression of FGF9 results in three to four times improved results in vivo. PGE2 is known to induce FGF9 over a 24 hour period in a bell response curve.
PGE2 and PGD2 will be purchased from Kane.
If interested please say so. Further, indicate which trial group you are interested in and any drugs you are currently taking. As stated, this is a trial being undertaken for the whole hair loss community not any one single forum. The results will be made publicly available per the organizers intentions.
Dermarollers are relatively cheap, between $10-20 on eBay. It would also be beneficial if members willing to take part in the trial posted their dermaroller as well.
I'll join in however I'll be starting propecia in conjunction with minox and nizoral next week as well. So maybe add a group E for outliers doing their own thing.
I'll be sure to give it a go on my hair line at least.
This is an interesting video about Microneedles and Minoxidil on You Tube:-
I'll be using Minoxidil 5% twice a day except for the day I use the dermaroller. Nothing else is in my regimen.
I use Regaine 5% Foam and this dermaroller:
Interesting i have restarted the dermoroller with my new topical and oral regrime which i have stopped using scalpmed due to cost and now on topical 5% minoxidil+antiandrogen+sucralfate 5% and avodart 0.5mgs a day as im getting some regrowth with scalpmed but the cost is way too high and 5% sucralfate does offer regrowth for mpb.
[QUOTE=doke;136617]try this link [url]http://www.follacure.com/t/sucralfate this is the trial of sucralfate for alopecia and mpb
be sure to use at least a 1.5mm roller. expect blood and pain! i used a 1mm with minox for a few months and noticed little to no improvement. There is nothing new about derma rolling, this study just gives us some guidelines to follow. and their reults were phenomenal.
I will probably use this in combination with Minoxidil, but the chance is high that I will also add finasteride within a month. Otherwise I would gladly participate. I love the idea, even though it's always hard to make sure people are not using other methods. I would only recommend to also include a group for those who are only on Minoxidil and are not interested in adding the dermaroller.
in that video, the guy doesnt understand how wounding works, positive results are not from increased absorption, but from the natural expression of growth factors post wounding. thats why u need to wait at least 5-7 days between wounding sessions.
Pge2 increases fgf9 expression wich allows for folicle neogenesis post wounding. without pge2 or minox, wich increases pge2 , folicle neogenesis cant occur, just scarring that can inhibit growth. This is essentially Follica's method.
yes rolling increases absorption, but that isnt the goal of this trial. thats why they did not apply minox 24hr after wounding in the study, to rule out increased absorption being the cause of regrowth. and u MUST wait at least five days bewteen roll sesions for the body to express these growth factors .
ps 1mm is too short , ive tried this, go with 1.5 or 2mm, no pain no gain. unless u incorporate topical lidocaine before wounding
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