Dr. Cotsarelis New Discovery that may finally cure Baldness (June 3rd, 2013)

[TravisB]

I've been finding and reading reports from Dr. Cotsarelis his 'revolutionary discoveries' for years on message boards which were posted back in 2004 and users praying and hoping for "in 10 years from now..."

With all due respect for Dr. Cotsarelis his research, it always helps to know more on a long term, but these kind of reports no longer make me warm or cold. Whether is between 10 or 10000000 years, there will be a cure one day. But I'm no longer getting my hopes up on a short term solution until I actually see proof.

This.

This isn't the first time Cotsarelis made a "breakthrough" discovery, and so far nothing useful came out of them.

[clandestine]

Every discovery helps really.

[KO1]

Follica has NOT tested this procedure in humans. The only procedure they did so far was a wounding+lithium trial in 2010, and they have not released results.

https://www.clinicaltrialsregister.eu/ctr-search/trial/2009-018191-34/DE

This trial involved wounding + twice daily applications of lithium gluconate.

As for whether this can be a DIY - many think yes. As for how deep? The clinical trial above notes two possible depths - one is just enough to remove epidermis, the other to get deep enough down to the subcutaneous fat.

What do we know we need?
1) Wounding
2) Wnt
3) Inhibit PGD2
4) FGF9

[TravisB]

Who started the rumor that they finished phase 2a trials?

[Thinning87]

article posted a few pages back

[TravisB]

article posted a few pages back

Ok I found it, it's here - http://www.prnewswire.com/news-relea...209914441.html

But we don't know if phase 2a is finished or is it in the works?

Besides, they tested wounding + lithium, not the fgf9 stuff.

Will they be testing wounding + fgf9 in phase 2b?

[Thinning87]

Ok I found it, it's here - http://www.prnewswire.com/news-relea...209914441.html

But we don't know if phase 2a is finished or is it in the works?

Besides, they tested wounding + lithium, not the fgf9 stuff.

Will they be testing wounding + fgf9 in phase 2b?

who knows they are very secretive. For all we know they may be doing so right now, or they may be restarting over with the new discovery. Unfortunately there is not much we can tell or do.

[TravisB]

I'm afraid that it will go as always - they will grow few hairs at best and call it a "success"

Norwood 7 dudes need way more than few hairs

[Thinning87]

is anyone watching the show? is this new stuff? there is basically no way to know when new content will be uploaded right?

[burtandernie]

Why dont they put out this story after they have proof it works in humans and grows some significant amount of hair? If its not doing that we can add it to the big pile of other stuff .

[Pentarou]

I'm trying to think through how this treatment would work in practice if it becomes a reality. Presumably you'd have to visit a clinic with the special Follica machine, make an appointment, shave yourself bald, have your head wounded by the machine and have the specially formulated topical treatment applied, however many times that wounding + topical solution combo was required to get results.

[clandestine]

You're getting ahead of yourself.

Who cares what mechanism it's administered, so long as it works.

[Thinning87]

I know seriously. It's hard to stay off the forum but I am going to try to be here less often as at this point I don't see how there can be any additional exciting news in the near future. The only things we may hear are

1) a press release from Histogen before the end of the year regarding their new partnership and the beginning of phase 2B (because I don't understand why it would take them longer than that to find a partner like Replicel did and move on)

2) Maybe, something from Aderans. Although I'm inclined to think there is something not working with their technology, if we have learned something this past week is not to write off any companies as the two companies everyone had given up on just came out with great news. Plus, they did indeed just finish their last phase 2 test, so I would imagine if there is anything to say it will be said before the end of the year.

Besides that, we know Replicel is going to do their thing for a while (they might let us know when they officially begin phase 2B but for now it's pretty much sure it's going to be before the end of the year) and I doubt we'll hear more from Follica as they have shown to be very secretive.

I guess we may expect something from Allergan for its higher dosed version of Bimatoprost, but these other drugs are less important in the battle IMO.

I just don't understand why everyone is so frustrated, I mean very little news comes out of the Edinburgh congress and everyone is excited to read threads from Nigam who, with all due respect, can't even dream of having some of the credibility Follica has.

Now all the sudden within 7 days we get Histogen adding 48 week data, Replicel financing and phase 2B trial, and Follica growth factor news. And how would someone expect this news to be taken by the forum? Given the way they greeted Nigam I was inclined to think people would start shaving heads and saying "**** it the cure has been found already". And instead no everyone's here so depressed and calling Histogen a failure based on someone claiming it is toxic based on some deduction they made reading the same data that had been published before and was accessible to all of us.

[UK_]

Just when Histogen seems to have let us down this pops up.

Is it a case of "Hope springs eternal" or “Hope is the worst of evils, for it prolongs the torments of man”

Nice post, I'm inclined to agree now more than ever before.

[UK_]

Has anyone read the description for the FGF9 research chemical?:

FGF-9
FGF-9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells. FGF-9 induces osteoblast proliferation and new bone formation in a bone organ assay. FGF-9 is produced by many prostate cancer cells and contributes to prostate cancer-induced new bone formation and may participate in the osteoblastic progression of prostate cancer in bone. It is also a an autocrine and/or paracrine neurotrophic factor that promotes the survival of motoneurons and upregulates choline acetyl-transferase activity.FGF-9 enhances survival of AChE-positive neurons, increases their mean soma size. It also up- regulates their choline acetyltransferase activity as potently as NGF and the effect is greater than that elicited by bFGF, CNTF, or GDNF. FGF-9 acts as a survival factor for neurons but does not promote neurite outgrowth. FGF-9 has been shown to mediate its effects by binding to FGF receptors. It efficiently activates the FGFR2c splice form of FGFR2 and the FGFR3b and FGFR3c splice isoforms of FGFR3.

http://www.reprokine.com/Human%20Fib...ant%20_id=3422

Lol, Yeah... I think ill wait for their trial results.