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Senior Member
Histogen's FINAL Phase I/IIa Results (2013)
Hey guys,
Histogen has finally published the results of their 12 month Phase I/IIa results. Here's the link:
http://www.histogen.com/downloads/ii..._hsc_final.pdf
There's a lot of information which is provided and requires extensive discussion.
1) Duration of Efficacy: Although the patients remained above baseline at the 48 week follow-up, the effects started to wear off by that point: % Change from baseline: 19% (Week 12) compared to 12% (Week 36). This means that patients will need booster shots at least ONCE A YEAR.
Also, isn't it odd how they haven't provided data on % change from baseline for the 48th week even though they did measure it! (Food for thought)
2) Total Hair count in the Temporal Region (temples) increased only by 2.5% at the 48 week follow-up.
3) Therapeutic Window: They found a direct relationship between dose and possible toxicity (Haemoglobin count). Therefore, only so many mL of HSC can be injected at a given session. Otherwise, your Haemoglobin levels may drop and lead to anaemia and other related conditions. This is very important, as it means you cannot get Histogen injected all over your scalp in a single session... HSC will be simply used in your most problematic areas to give you that extra boost in hair density.
4) Safety: using only 8 shots of HSC lead to no abnormal parameters in trial subjects. Furthermore, all reported side effects were mild and transient, which is a big plus.
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