Histogen Update - Spencer Kobren Speaks With Dr. Craig L. Ziering

[gmonasco]

Originally Posted by UK_

Nobody on this website can show me a single treatment that can safely create new hair growth/ enhanced thickness of existing hairs maintained for up to 2 years, even if you went through every treatment/experiment over the last century. so yes, it is remarkable. How many new hairs have you grown in your lab with your treatment this year?

Hint: A hair follicle cycling from telogen to anagen phase isn't really "new" hair. And nearly all (normal) hairs produced as the follicle transitions from telogen to anagen last at least two years.

[gmonasco]

Originally Posted by RichardDawkins

Even if it would just awake hairs in their anagen or telogen state, its highly unlikely that this hair would survive for more then 2 years with only one single injection.

Why not? The normal telogen/anagen cycle for a follicle is anywhere from two to six years.

[CVAZBAR]

Originally Posted by gmonasco

Why not? The normal telogen/anagen cycle for a follicle is anywhere from two to six years.

Did you ever ask Doc Z any of these questions? If he was sure it wasn't just the normal telogen/Anagen cycle. If so what did he say?

[gmonasco]

Originally Posted by CVAZBAR

Did you ever ask Doc Z any of these questions? If he was sure it wasn't just the normal telogen/Anagen cycle.

No, I haven't. But it's always something that should be considered when the "before" pictures have a fair amount of hair in them to begin with:

[CVAZBAR]

Originally Posted by gmonasco

No, I haven't. But it's always something that should be considered when the "before" pictures have a fair amount of hair in them to begin with:

You should ask. That would be a good question because Doc z seems to have a lot of faith in this product. I wanted to ask you a question G. What do you believe in? I mean do you have faith in any product? You are very active in this site but you rarely show optimism in anything.

[UK_]

Originally Posted by gmonasco

Hint: A hair follicle cycling from telogen to anagen phase isn't really "new" hair. And nearly all (normal) hairs produced as the follicle transitions from telogen to anagen last at least two years.

But how do you know if that is happening? The literature regarding the mechanism behind WNT 7A unfortunately does not support the hypothesis you are proposing, you also have no objective basis upon which to make such an assertion, a hypothesis should atleast have some justification. If the researchers believe this product is signalling stem cells already in the scalp to produce new hairs per follicular unit, then that is a contention I would prefer to support as researchers only make such assertions if they are theoretically plausible whence referring to the literature, which is exactly what Histogen do.

WNT 7A has been shown in animal models to GROW TOTALLY NEW HAIRS IN BALD MICE - (LITERALLY MICE WITH NO HAIRS). It did not achieve this through ANY of the mechanisms you are proposing here, I suggest you do a little research on what WNT proteins really are, and the power behind them, these arnt your run-of-the-mill compounds believe me.

[UK_]

Originally Posted by gmonasco

No, I haven't. But it's always something that should be considered when the "before" pictures have a fair amount of hair in them to begin with:

So what? The study was conducted on patients right up to NW6, who did responded to treatment, so if this product does come through, we could have a potential treatment for ALL stages of hair loss. What you see in those pictures is not of importance, your eyes will never tell a clearer story than the statistical measurements/results that form the real substance of the success of this study.

If this is the method you are using to subvert the results of HSC, then please exit this thread and visit:

http://www.alibaba.com/product-gs/30...ly_7_days.html

According to your logic, this product has more viability than HSC.

[RichardDawkins]

@gmonasco : Its easy, those hairs have been "dead" before so it would be highly unlikely that a small injection could get them to actually start their cycling again (considering HSC would fail as you put it)

And the other thing is, even with regards to your concearns, to me it seems that the worst case would be hair, which succumbs to DHT again after the initial amount of years, it took this hair to succumb in the first place.

But this life span would be also expanded becaus DHT concentration decreases over years.

[GBB]

Originally Posted by RichardDawkins

@gmonasco : Its easy, those hairs have been "dead" before so it would be highly unlikely that a small injection could get them to actually start their cycling again (considering HSC would fail as you put it)

And the other thing is, even with regards to your concearns, to me it seems that the worst case would be hair, which succumbs to DHT again after the initial amount of years, it took this hair to succumb in the first place.

But this life span would be also expanded becaus DHT concentration decreases over years.

Amidst all this happy talk (and I sincerely do believe Histogen has the pieces to the puzzle), I am really worried that there has been no news about the Singapore trials till date. I read somewhere that it starts in May now. The Web site still says spring though. Isn't May summer? The trials have already been pushed back twice, and we really don't know whats going on.
I had received a prompt reply from Histogen when I had written to them earlier, of late though, information is a little hard to get.

Also, as someone pointed out earlier, a roughly 40% increase in hair count happened to the best responder. If the average increase in absolute hair count was around 15%(according to the graph), what was the increase in the number of terminal hairs? Do people with more advanced stages of hair loss respond any better or worse?

[Sogeking]

Actually May is in spring. Spring has started yesterday and will end on 21st of June. Well that is by calendar, astronomical spring started on Mar 20 @2321 UTC. And meterological on 1st of March .
However they were constantly saying early spring. For me that is end of March and April... And now we hear it is May?

Anyways I'm concerned about this silence myself.
So basically I just want them to start with the clinical trials. I guess we'll have to wait for May...

The next clinical trial of HSC is currently in planning stages, and is scheduled to begin in Singapore in early 2011, with plans for pan-Asian approval in 2014. Estimated U.S. market introduction of the injectable for hair regrowth in the treatment of male pattern baldness is 2015, with potential for earlier introduction in certain identified countries.