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Old 12-08-2010, 12:44 PM   #11
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Okay so if we all agree that plucked hairs can actually form functional follicles in rare cases.
Wouldn't you agree that if A-cell can be used to raise the rate of success to about 75 %, that it would definately be a major breakthrough.

I am 23 and am about NW4, with thinning in a NW6-7 pattern, not the average ideal candidate for a traditional hair transplant.

However if plucked hairs can be used (even if they grew in thinner than regular hairs, which is something that Dr. Cooley does not seem to have observed) maybe even in conjunction with a regular transplant - that could change everything especially for all the young balding guys out there.
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Old 12-08-2010, 02:13 PM   #12
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Gubter_87, I didn't mean to come across as flippant about the potential that this could be an amazing breakthrough for hair loss sufferers- I personally would love that as much as anyone. I just don't have my hopes up, with the evidence that has been presented so far, that this will be THE answer to everyone's prayers. By saying there was nothing 'novel', I meant in the notion that transacted follicles (plucked hairs) can regrow. We'll have to see side-by-side studies (on a bald head) to know for sure whether ACell actually has the ability to affect the survival rate of plucked hair. Further studies (or explanation from Dr. Cooley) are also needed- for example, to determine what constitutes a viable plucked hair: how much of the formative tissue must be left behind to achieve regrowth in the donor area and how much must be removed to actually get it to grow in the recipient area?- before people get too emotionally invested in this 'breakthrough'.
Disclaimer: I am not a physician. My opinions are not necessary those of Dr. Cole. My advice is not medical advice.
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Old 12-08-2010, 02:31 PM   #13
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Unless Dr. Cooley is lieing, he has been able to achieve a survival rate of 75 % for plucked hairs. If it is because of A-cell (which is probable) then great. However if this has nothing do to with the use of a-cell, and the good succes rate is just because of Dr. Cooleys plucking technique - then even better! I don't really see the issue.

Fact is if Dr. Cooley technique achieves these results - it is a major breakthrough for hair loss sufferers as it greatly increases the donor making it basically infinite.

Sure - we need to see more evidence. But I see no reason to doubt Dr. Cooleys initial findings as he is a reputable hair loss suregon.
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Old 12-09-2010, 04:11 AM   #14
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just my opinion , if i only got 75% growth i would be pretty upset !
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Old 12-09-2010, 06:05 AM   #15
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Originally Posted by ejj View Post
just my opinion , if i only got 75% growth i would be pretty upset !
Really? I would be thrilled if I got 75% growth from plucked hairs. That would be much more valuable than 100% growth from FUE or strip because the donor reserve would still be intact.

As long as the vast majority of the plucked hairs grow back which they should, I really cannot see a reason to be this dismissive of the new approach.

And I certainly cannot understand how someone can justify that it is okay for the donor hairs to be taken out in FUE not to grow back ever again in the donor area, and then make such a big deal about the plucked hairs coming back weaker. Is it because the survival rate is higher for FUE? What if this new method comes close or even better catches up with it? Given that it already achieves 50-75% despite being so new, why not?
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Old 12-09-2010, 09:56 AM   #16
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The autocloned hair does not come back weaker. A simple email or phonecall to Dr. Cooley's office would confirm this. The donor grows back and the recipient grows in approx. 75% of the time. These are the facts that Dr. Cole is trying so desperately to muddy.
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Old 12-09-2010, 01:04 PM   #17
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I don't know why you guys are so up in arms about Dr. Cole’s post, it’s simply his point of view. It doesn't change the fact that Dr. Cooley is still experimenting with Acell and it doesn't change what Dr. Cooley believes about it’s effectiveness. Time will tell if this is the breakthrough that we have all been hoping for.
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Old 12-09-2010, 02:37 PM   #18
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Originally Posted by Winston View Post
I don't know why you guys are so up in arms about Dr. Cole’s post, it’s simply his point of view. It doesn't change the fact that Dr. Cooley is still experimenting with Acell and it doesn't change what Dr. Cooley believes about it’s effectiveness. Time will tell if this is the breakthrough that we have all been hoping for.
Just for instance: A comment like that …

Originally Posted by drcole View Post
He did not discuss hair plucking with me during this phone call. He did relate his own personal experience by having his nurse punch into his scalp in an ACell treated area of scar and a non-ACell treated area. He said the punch crunched into the non-ACell scar site while it slid softly into the ACell scar site without making a characteristic crunching noise that is audible to the patient. The ISHRS has issued a position paper. The position paper clearly states that it is the opinion of the ISHRS that only licensed physicians should be punching into the scalp or performing FUE. This is simply food for thought as Dr. Cooley is now the ISHRS president.
… has absolutely NOTHING to do with “it’s simply his point of view”. Absolutely nothing!

By the way: Dr. Cole is talking here (quote/comment) about this subject:

But here I’m talking about that subject – the ISHRS called it “unprofessionally cat fight”:
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Old 12-09-2010, 03:16 PM   #19
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Post "food for thought"

Originally Posted by HairRobinHood View Post

But here I’m talking about that subject – the ISHRS called it “unprofessionally cat fight”:
"This is simply food for thought", Mr. Cole!
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Old 12-09-2010, 03:46 PM   #20
John P. Cole, MD
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New grafts do tend to grow in finer initially, but often take on a thicker diameter as they mature. I would expect a similar course with plucked hair. We’ve had enough time to evaluate hair diameter, but like much of the material Dr. Cooley has presented, he has not taken enough time to draw any conclusions with respect to diameter, and he has not assessed diameter in a scientific manner. Dr. Cooley has not presented any evidence that plucked hairs are as coarse as the donor hair. In fact, one of the few comparison he’s made at all is the scalp plucks to the beard plucks. Here the beard plucks were much finer than traditional beard hair and as fine as the scalp hair plucks. This simply does not occur based on my considerable experience grafting beard hair. In other words, the direct comparison photographs clearly show a finer nature to plucked beard hair grafts. Measuring hair shaft diameter requires specialized equipment if you are going to get reliable results. I own it and would be more than happy to assist Dr. Cooley in a scientific study that evaluated hair shaft diameter. Thus, far, however, Dr. Cooley has presented no scientific evidence that indicates that plucked hairs typically grow in as coarse as the donor hair source. What he has done is say that plucked hairs grow in finer than FUE hair. If he wants to alter this statement, he would need to provide me with scientific evidence that supports his conclusions.

Many of the results depicted were in their infancy. If something changes in their appearance over time, I would be the first to accept this as an improvement in the technique, but there still would be a complete lack of scientific data. In the mean time, we have direct comparison of grafts obtained by FUE and grafts obtained by plucking. In Dr. Cooley’s own words, the FUE hairs were thicker than the plucked hairs. If the grafts were placed at the same time, then you would expect them to be on a similar maturation schedule. We can leave it to Dr. Cooley to follow his results and evaluate the diameters over time. He can then report them. His goal should be to measure the diameters before transplantation and then again after transplantation. I do not know if he has the equipment to perform this study in his office, but as I stated, I have it in mine.

What is missing from all these presentations is reputable science. I’ll discuss this as it relates to “autocloning”.

1. A study must include an introduction, methods, results, and a discussion. The conclusions in the discussion should be based on the results and they should answer the questions you create when you design the study. When you start the study, you must determine what you want to prove. Then you must design a method that will allow you to gather results that will support or disprove your hypothesis. Both Dr. Cooley and Dr. Hitzig skipped the methods, presented unconvincing results, and came to conclusions that were not supported by their results. Their entire effort was flawed from the beginning due to poor scientific method.

There is no direct comparison of plucked hairs treated with Acell and plucked hairs untreated with Acell in a bald crown. Therefore, not only do we have no idea whether Acell impacted the growth of viable plucked hairs, we also do not know if Acell alone impacted the growth because the grafts were predominately place in hair bearing zones. Isn’t possible that Acell alone induced growth? One must isolate variables if they want to evaluate them individually.
There is no evidence that hairs plucked from the donor area regrow in the donor area. In order to have cloning, you need to create more than one hair. Not only have the physicians failed to verify this, we have no evidence what so ever that a single hair re-grew in the donor area. Am I the only one who finds this comical? From my perspective I see the advocates eulogize their logic this way. They plucked some hair, put some Acell on it, put the pluck in the recipient area, showed them some growth, and told them it grew back in the donor area. They’ll be too trusting or too stupid to ask Dr. Cooley to show them the proof because of the physician’s reputation. Sure they’ll have to pluck 200 hairs to get 80 that grow, but who cares. Let’s toss in the word cloning and they’ll be so excited that they won’t care that they did not follow a scientific method or prove a single point they made. Bernie Madoff would have loved some guys who swallowed this stupid pill. You might still be able to invest money with Intercytex too. Even body hair works better than their potions, but some people simply become delusional when they hear the words, “hair multiplication or cloning”.
What are the methods. You can’t have a study without first defining the methods. This includes the technique you use to pluck a hair and what constitutes a viable plucked hair. How are you going to verify that a plucked hair actually regrows in both the recipient area and the donor area? How are you going to identify the plucked hair in the donor area. Suppose you have a two hair follicular unit and one hair is resting in the exodus stage. All you see is a single hair. You pluck it. You come back 3 months later and see a hair. Was that the hair you plucked or the hair that was in the exodus stage.

Other questions I’d like answered would be the yield. You can’t simply throw out a number and say, I wish I knew the specific number, but I think it is 75%. That’s not science. Furthermore, some cases might have good yields and some might have poor yields. I learned this the hard way with body hair. The same could occur with plucked hair. How many plucked hairs survive with Acell and how many survive without it. If you pluck 100 hairs, how many will regrow in the donor area and in the recipient area. How many hairs do you have to pluck in order to get 100 viable hairs. Do we need to pluck 500 hairs to get 100 that are viable plucked hairs? What happens to the non-viable plucks. What percentage of these non-viable plucks survive in the donor area? Sure we know that plucked hairs can grow back, but we also know that they do not always grow back. Why do women often need eyebrow transplants? Their plucked hairs did not always grow back! Why do people with a compulsion to pluck their hair, trichotillomania, often present for hair transplants? Their plucked hairs did not always regrow. Don’t mislead yourself. Plucked hairs do not always regrow!

Here is another example of an unscientific study that lacked methods designed to evaluate a hypothesis. With regard to scar width, Dr. Cooley presented one example of a 2 cm wide scar that resulted from another physician. The other physician excised the scar once more and it returned to a 2 cm wide scar. Then Dr. Cooley excised the scar and added Acell. The resulting scar was 6 to 7 mm at 4 months with Acell. The plan was to excise the scar again and hope for an even finer result due to the affects of Acell. My comments are as follows: An acceptable width for a strip scar is 0.5mm to 5 mm. A strip scar that is 2 cm wide is the result of poor physician technique, it is iatrogenic. Dr. Cooley feels that the reduction in the width of the scar to 6 to 7 mm in his hands was due to Acell because the original physician’s attempt at revision failed and produced another 2 cm wide scar. There are multiple factors that can affect the width of a scar revision. In 1993 I began closing my revisions in two layers. In almost all instances, the width of the scar decreased by 50% or more. With every scar revision that I’ve done, I’ve told patients that the scar may resume it’s original width, be wider, or finer. Usually they are 50% their original diameter or less. In fact, I have never revised a scar left by another physician that did not reduce in diameter though I tell every patient the scar could be the same width or wider. The point is that there are multiple factors that can affect the width of a scar other than Acell. If you don’t know the technique used by another physician, you can’t compare your technique to that of the other physician. Examination of a strip scar that was 2 cm in diameter immediately tells me that the other physician did not use excellent technique. Thus you can’t compare the two scar widths based on Acell alone. Furthermore, I can tell from the photos that the revision performed by Dr. Cooley was in multilple layers. Otherwise, the wound would have been much wider than 2 cm rather than finer when he was placing the ACell. Might the use of two layers alone have decreased the scar diameter? Of course. In addition, some physicians attempt to get additional grafts out with a revision. Perhaps rather than excising the scar alone, the original physician excised more than 2 cm and put unacceptable tension on the wound at closure. In other words, we don’t have enough information to make a determination if Acell improved this scar. Closing one side with Acell and the other without Acell using the same method of closure other than Acell would have given us an idea, but we would have required a minimum of 6 months to make the initial observation. Once again, no methods were mentioned and no comparison was performed. The methods were not designed properly to evaluate the hypothesis. We can’t evaluate this result. Never the less, Dr. Cooley drew the conclusion that Acell improved the width of the scar even though the results did not verify the conclusion. All we can do is be happy for the patient as the scar is finer. This too is an immature result, however. Scars do not begin to widen until the 3rd month usually. When they do widen, they continue widening out to the 6th month. We need to wait until at least 6 months to evaluate the results of this closure.

As an example suppose I want to reduce blood pressure. I could surmise that the sugar in the gum a patient chews is elevating blood pressure because it has more calories, elevating his weight, and increasing resistance on his vasculature. Therefore, I start my patient on sugarless gum and 6 months later we find that his blood pressure drops from 160/110 to 140/80. We then present our findings and conclude that sugarless gum lowers blood pressure because it has fewer calories. What we failed to disclose was that we also routinely put our hypertensive patients on a 1800 calorie per day diet and hire a personal trainer for each patient. Would the drop in pressure be the same without the diet and exercise? Who knows, but we certainly can’t attribute it strictly to sugarless gum once we know all the variables that were not disclosed in the study. The only way to evaluate a single variable is to isolate it and study it under a strict scientific methods. The lack of a scientific method is exactly what we find in all these examples. There are no independent variables. Without isolating the variables we cannot evaluate them.

I can go back to every example that Dr. Cooley presented and show a disconnect between the results and the conclusions based on a lack of scientific method. The presentation is interesting and nothing more. The conclusions are humorous.

In the mean time there is no evidence that autoclonging exists. If it did, I would expect Dr. Cooley to cease performing strip surgery altogether and simply pluck hair. I suspect he is a long way from that point as there are simply too many unanswered questions. The most important question is whether anything grows back in the donor area when you take an almost completely intact follicle or of the donor area. What we do with FUE is take out completely intact follicles. In the absence of Acell, they do not grow back in the donor area. In the absence Acell an almost completely intact follicle has about as much chance of regrowing in the donor area as a fully intact follicle. One question he is seeking is whether these nearly intact follicles that would have grown without Acell might not regrow the next cycle. They will follow the same cycle as a fully intact follicle most likely. I’m not sure he understands exactly what he is doing, which is transplanting nearly intact follicles. Acell might improve survival in the recipient area of nearly intact follicles, but Acell is not going to affect the life cycle of a nearly intact follicle, because it is essentialy a normal transected follicle that grew on transplantation and will continue cycling most likely. There is no magic here.

Now, wolvie, let me make something clear to you. There is no scientific data to prove a single conclusion you allude to. There is no evidence that the plucked hairs grow back at the same diameter as they were in the donor area. There is absolutely no evidence what so ever that anything similar to autoclonning occurs. Dr. Cooley performed no survival studies so there is no evidence that the survival rate is 75%. You seem to have a great deal of difficulty connecting the dots. Read my lips...Dr. Cooley presented no data what so ever to indicate that even a single viable plucked hair grew in both the donor area and the recipient area. I have no idea what your agenda is, but your conclusions are simply a leap of logic or hallucination. We all want to believe hair plucking works including myself, but no one can draw scientific conclusions based on faulty studies. Now, if you want to pull the Dr. Cooley card on me, feel free to have him give me a call or debate me on a forum. We’re not enemies or competitors. We’re colleagues who are both interested in making lives better. I welcome evidence that refutes my position simply because it will improve the possibilities for all individuals with hair loss. If it does not pan out, however, the impact on the finite donor area would be deleterious. Don’t count me to be on the bridge of that ship. In other words, show me the science.

Suffice it to say that if he is proven accurate, we are all going to stop traditional harvesting methods and start plucking hair. The aesthetic benefits are as valuable as the potential for an unlimited donor supply. There are about 100,000 hair transplants in the USA each year and the majority of them will be plucked hair. They will certainly benefit from technology that expands their donor area while minimizing scar formation. Until then, patients should proceed slowly with this technology. I think 200 plucked hair is a good number for a procedure at this time. We need conclusive science before anyone becomes more aggressive with this technology.
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