Originally Posted by PatientlyWaiting
You mean while also using minoxidil?
If not, keep in mind that MPB is a gene. You can't just roll little needles on your head and it will stop the hairloss. I'm pretty sure the whole point of a dermaroller is for more minoxidil absorption.
1) You're wrong on every account.
2) Its not about just 'rolling' little needles on your head.
3) Minoxidil absorption has NOTHING to do with it.
The objective and facts are:
Dermarolling is not meant for absorption but for WOUNDING. It is a known FACT that when wounding occurs, WNT and FGF-9 is induced during the healing process. Keep in mind WNT is the same stuff Histogen is using for their method of injections, so this already holds weight. FGF-9 was shown to grow a significant amount of hair on mice but when removed, hair did not grow. A similar pattern occurs during the wounding process in human scalp, however FGF-9 is produced in lower numbers. It is however thought that the addition of Minoxidil AFTER wounding will elevate PGE2 levels which in itself also elevates FGF-9. FGF-9 along with WNT both *should* induce growth in hair. Both of which theories are documented and published by, you guessed it, Dr. George Cotsarelis. Read here:
Look for this part in that article:
“We showed that wound healing triggered an embryonic state in the skin which made it receptive to receiving instructions from wnt proteins,” says senior author George Cotsarelis, MD, Associate Professor of Dermatology. “The wnts are a network of proteins implicated in hair-follicle development.”
As for FGF-9, here's what he has to say:
In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.
The recent study had these results:
To further give evidence of this theory, heres an article from 1986 mentioning a scalp burn victim with MPB regrowing terminal hair after the burn healed:
We also know that in thinning hair, scalp also thins. However dermarolling alone increases collagen production which thickens up skin. This was mentioned by Spencer on his show not long ago in regards to the dermarolling approach. In my opinion (though this is my only theory) a good environment for hair follicles will also play a role, so essentially a DHT free zone with good skin should provide results. I myself will be trying out EMU oil as its known to improve skin. The addition of dermarolling, minoxidil, and a DHT inhibitor like RU58841 or an oral one like Dutasteride should provide results.
So the dermaroller only costs between $10-$40 and will *at least* help with absorption. This, you are right about. However, there is *no reason* not to replicate this study and see what happens.
PrettyFly83 is already seeing results and has posted a link to the dermarolling thread, I would strongly suggest you read over it and at least give it though: