Hair growth-promoting stem cells acquired supra-regenerative capability when treated with vitamin D3, laboratory studies showed.
Hairless skin from rats grew significantly more hair when inoculated with D3-treated murine dermal papilla cells (mDPCs) than did skin specimens exposed to murine dermal fibroblasts treated with vitamin D3, Japanese investigators reported online in Stem Cells Translational Medicine.
The researchers also found that human DPCs treated with vitamin D3 exhibited upregulation of Wnt10b and transforming growth factor beta-2 (TGF-β2). Both genes are associated with folliculogenesis, and their vitamin D3-induced upregulation was specific to hDPCs and not seen in human dermal fibroblasts.
Collectively, the results suggest that vitamin D3-stimulated DPCs has potential as a treatment for baldness in humans, Aoi and colleagues concluded.