Spencer Kobren Speaks To Dr. Craig Ziering - Histogen’s HSC Update 6/16/12

[Dazza]

http://clinicaltrials.gov/ct2/show/N...istogen&rank=1

Current trial

[rdawg]

Originally Posted by Dazza

http://clinicaltrials.gov/ct2/show/N...istogen&rank=1

Current trial

Hmm I think that clarifies that the actual hair stimulating complex is going to be heading into phase I/II part 2 in January, not Phase III. Still we'll see how positive the results were for this phase.

[UK_]

Originally Posted by rdawg

Hmm I think that clarifies that the actual hair stimulating complex is going to be heading into phase I/II part 2 in January, not Phase III. Still we'll see how positive the results were for this phase.

I dont know, maybe they will maybe they'll go straight to Phase III. You know I remember Gail stating way back in 2010 that the product could be due for pan-Asian release as early as late 2013, but who knows.

[Pate]

Originally Posted by rdawg

Hmm I think that clarifies that the actual hair stimulating complex is going to be heading into phase I/II part 2 in January, not Phase III. Still we'll see how positive the results were for this phase.

Sorry, how does it clarify that? I must be missing something.

I suspect they will do a proper Phase IIb before a Phase III, much as I hope they go straight to Phase III. But I don't see anything in that clinicaltrials.gov record that clarifies they're doing Phase I/II part 2?

If anything, this is Phase I/II part 2, because the original study was I/II part 1.

[rdawg]

Originally Posted by Pate

Sorry, how does it clarify that? I must be missing something.

I suspect they will do a proper Phase IIb before a Phase III, much as I hope they go straight to Phase III. But I don't see anything in that clinicaltrials.gov record that clarifies they're doing Phase I/II part 2?

If anything, this is Phase I/II part 2, because the original study was I/II part 1.

Well it's not a for sure, but according to that link, the actual hair product/hair solution(HSC) is only phase I, the technology/device is phase II, telling me the product will be going into phase II now. I could be wrong though.

either way if it passes this phase, it's ONLY good news, and depending on the results we could know it already works whether it's going into phase IIb or phase III.

this is only for europe though, NA is going to be behind a year or two even after approval of this in europe(if it gets that far.)

if this passes in december to the next phase, we're looking at a late 2014 launch in Europe/Asia and late 2015-2016 launch in NA.

[Pate]

Originally Posted by rdawg

Well it's not a for sure, but according to that link, the actual hair product/hair solution(HSC) is only phase I, the technology/device is phase II, telling me the product will be going into phase II now. I could be wrong though.

I don't think that's what it means. I think you are supposed to read them in columns, not rows.

ie the formulation tested contains both HSC and DMEM (which is the cell conditioning serum that grows the fibroblasts), and the formulation is being tested in both Phase I and Phase II.

But yeah, no matter what it is, the 3 month results were fantastic. I'm waiting impatiently for the next results. One of the subjects nearly doubled his total and terminal hair counts at 3 months - his results at 12 months will be very interesting. Subject S1027 in the previous trial only had 5% more total hair at 3 months, but 50% more at 12 months.

[UK_]

The great question is whether this will grow hair in slick bald areas - if it doesnt we can always concentrate 100% of HT grafts on the hair line then use HSC in the crown area to get density back

[rdawg]

Originally Posted by UK_

The great question is whether this will grow hair in slick bald areas - if it doesnt we can always concentrate 100% of HT grafts on the hair line then use HSC in the crown area to get density back

The guy from histogen interviewed in june said they had JUST injected a slick bald area on a new test patient. so it's been about 3-4 months. Undoubtedly we'll find out in October.

If it only adds density or reverses vellus hairs, that's still great for thinning or moderate hair sufferers.

[UK_]

Originally Posted by rdawg

The guy from histogen interviewed in june said they had JUST injected a slick bald area on a new test patient. so it's been about 3-4 months. Undoubtedly we'll find out in October.

If it only adds density or reverses vellus hairs, that's still great for thinning or moderate hair sufferers.

Definitely, so long as its better than propecia and minox its a successful treatment, people with higher norwoods would benefit from having this treatment combined with a HT. And continued injections into recipient and donor areas AFTER the treatment too.

They could actually distribute this product as a treatment to have every 6 months after a HT to ensure continued hair growth on top of transplanted grafts.

[Conpecia]

Anyone know when in October to expect the update?