Dr. Cotsarelis interview about PGD2.

[Sogeking]

http://www.aad.org/dermatology-world...etic-alopecia-

Dr. Van Voorhees: Does this research open up possible avenues for treatment approaches that have not yet been considered? Are there currently drugs under development which might be utilized?

Dr. Cotsarelis: This work suggested that D2 was working through the GPR44 receptor to inhibit hair growth. It turns out that there are compounds under development by a number of companies to inhibit this receptor. They are being developed for asthma and allergic rhinitis. PGD2 causes bronchoconstriction — when you inhibit its receptor you relax smooth muscle so it helps with lung disorders. No one is developing a topical formulation, but we think if you did, it would be a potential treatment for alopecia.

Dr. Van Voorhees: Should this allow for reversal of previously lost hairs or do you expect that it will only play a role in retaining hairs that have not yet miniaturized?

Dr. Cotsarelis: We don’t know. Like anything you’d have to test a large number of people to see how they respond. We don’t know if people who are already completely bald will regrow hair. We do know that the stem cells are present in men who are balding so if this is indeed the inhibitor preventing stem cells from making progenitor cells, there’s a possibility this would help there as well.

It is amazing how complex the problem of miniaturization of hair follicles is. I hope PGD2 works, however I'm inclined to believe that in best case scenario we will get a better working propecia with lesser and milder side effects. Which is still great...

[BoSox]

"Dr. Van Voorhees: Should this allow for reversal of previously lost hairs or do you expect that it will only play a role in retaining hairs that have not yet miniaturized?

Dr. Cotsarelis: We don’t know. Like anything you’d have to test a large number of people to see how they respond. We don’t know if people who are already completely bald will regrow hair. We do know that the stem cells are present in men who are balding so if this is indeed the inhibitor preventing stem cells from making progenitor cells, there’s a possibility this would help there as well."


grrrr, I wish it didn't have to take this long to find out if it reverses hair loss, there's got to be a way to find this out sooner rather then later.

[MoreCoffee]

Yes we can all wait for something topical to be made....Oh wait, that's right, NO ONE company is trying to make a hair treatment based on this discovery. What are we waitong for??..nothing is in the works.

[2020]

Originally Posted by TimAllen45

Yes we can all wait for something topical to be made....Oh wait, that's right, NO ONE company is trying to make a hair treatment based on this discovery. What are we waitong for??..nothing is in the works.

wtf are you talking about?

http://oxagen.co.uk/crth2-1.htm

[neversaynever]

Originally Posted by 2020

wtf are you talking about?

http://oxagen.co.uk/crth2-1.htm

There is no mention of hair treatment on that site. Though im still very curious about it, as my allergy to dust and hayfever really kills me once a year. Anyone got in contact with them?

Id be more excited about a topical for hairloss. In theory, if its such a big help for asthma, it could end up replacing fin. Interesting.

If baldness is a type of allergic reaction involving DHT, which increases PGd2 around follicles...then OC000459 might just halt hair loss, and possibly re-grow. Shame we have to wait!

Wow, this company is located 20 minute drive away from me!

[2020]

Originally Posted by neversaynever

There is no mention of hair treatment on that site.

so what? What stops you from buying it and using it for hair growing purposes?

[neversaynever]

Originally Posted by 2020

so what? What stops you from buying it and using it for hair growing purposes?

True. These guys need more attention...

Anyone know about their plans and schedule?

[neversaynever]

Originally Posted by 2020

so what? What stops you from buying it and using it for hair growing purposes?

The dosage is low, and they are testing it for 28 days on patients, for asthma. the success of PGD2 blockers might come down to doseage because we do need SOME pgd2 in our scalps.

I really dont think we should wait for these companies to give us a PGd2 blocker.

I wish a band of us should get more proactive about getting a lab to cook it up for us. But we'd need a PROPER science guy to verify the pureness.....

[ferwin]

This one seems to be more PGD2 specific: http://www.ncbi.nlm.nih.gov/m/pubmed/2469708/

f

[UK_]

Cure for hair loss:

Have a sex change.