Replicel Results Double Digit Growth

[BoSox]

Originally Posted by JDW

wasn't aimed at anyone in particular dude, all in the same boat here so fingers crossed eh?

I agree, and my comment wasn't because of what somebody said.. I just wanted to clarify that I'm excited about Replicel, and feel bad for negative comments in the past.

[Follicle Death Row]

Not sure if it was Matt, Spex or Joe that said more likely closer to 15 than 5 years, but damn I'm beginning to believe them. 'Course they would say that. Kidding of course.

[krewel]

Replicels results are good, but people just don't want to understand, that it's a safety trial. I don't know what people think, it was just one injection in Phase I. Just because they used the highest dose, it doesn't mean x % is the max, they can get out of it. And secondly, it's not a "booster" like Histogen. It's a progress, including cell migration and recruiting, which takes a lot of time, and making this progress work properly is extremely difficult and subject of Phase II, I really hate being rude, but this whole idiocy is comming from hair site and all of its members.

Prof.Dr.Hoffmann: "Phase I trials are about safety, so a successful trial is, of course, about safety. Most people on the outside are not interested in safety; they’re interested in hair growth. For the regulators, the first thing we must prove is that it’s safe. A successful trial will prove that it’s completely safe, with no adverse effects like ganuloma or tumor formations. A very successful trial would mean we see more hair growth at the levels we would expect to see in a patient treated with Rogaine®. So, a range of 10 percent to 15 percent more hairs per centimeter square is what we would define as very successful."

But what does Hoffmann know, he has just been focusing all his life on hair research to waste his time with Replicel, right?

[gmonasco]

Originally Posted by krewel

Replicels results are good, but people just don't want to understand, that it's a safety trial. I don't know what people think, it was just one injection in Phase I.

Yes, it was primarily a safety trial, but it was also a Phase I/IIa trial (rather than a straight Phase I trial), so there was an element of efficacy to it, and David Hall certainly played up the notion that they were expecting (or at least hoping for) some whizbang efficacy results. So it's hard to blame people for having mistakenly high expectations of the trial results, as Replicel did a good deal towards fostering those expectations.

[krewel]

Originally Posted by gmonasco

Yes, it was primarily a safety trial, but it was also a Phase I/IIa trial (rather than a straight Phase I trial), so there was an element of efficacy to it, and David Hall certainly played up the notion that they were expecting (or at least hoping for) some whizbang efficacy results. So it's hard to blame people for having mistakenly high expectations of the trial results, as Replicel did a good deal towards fostering those expectations.

It was a Phase I/IIa trial because the patiens of Phase I will be included in Phase II. Just compare Histogen Phase I results with their Phase II PRE results, the difference is enourmous. But still there are people saying "oh, this will not be enough, screw Histogen, scammers."

Another thing people don't understand, is the measurement of regrowth in percentage. Just because the number is not 100%, it doesn't mean you can't get your hair back (especially not in Phase I, where they recieved only a single injection). 100% regrowth DOES NOT MEAN 100% of your gone hairs come back.

All in all, I can say that there is no reason to be disappointed. Quite the contrary, the results are encouraging.

[JDW]

and as established on here IF it inhibits exisiting follicules from DHT then it could work with another treatment, maintaining, whilst another restores...