Histogen Update - Spencer Kobren Speaks With Dr. Craig L. Ziering

[neversaynever]

Originally Posted by jpm

I agree. Histogen are already very exciting in the progress they have made and the potential to produce a very good treatment. Therefore any other exciting news, no matter how small, is a bonus.

By the way, everyone who says that at 3 months its too early to have any news. At 3 months during the Phase 1/2 trial, 16% regrowth had already been seen!!

I get confused with the histogen % figures. Is that 16% average across all patients or just the highest figure at that point?

[2020]

There is no reason to be negative at this point.... They're not cloning cells or anything, their procedure isn't nearly as complicated compared to other guys. As long as their stuff doesn't grow tumors at high doses, everything else will work out

[gmonasco]

How does Histogen come up with hair count figures like 126.5? What constitutes half a hair? Is there some kind of averaging procedure involved in the hair count process?

[2020]

Originally Posted by neversaynever

I get confused with the histogen % figures. Is that 16% average across all patients or just the highest figure at that point?

dude.... it's all on the first page of their site:

http://jddonline.com/articles/dermatology/1650

At the initial 12-week evaluation period, HSC-treated sites demonstrated an increase in hair shaft thickness (6.3% ± 2.5% vs. -0.63% ± 2.1%; P=0.046), thickness density (12.8% ± 4.5% vs. -0.2% ± 2.9%; P=0.028), and terminal hair density (20.6 ± 4.9% vs. 4.4 ± 4.9%; P=0.029).

terminal hair density: average was 20.6% with some subjects getting as much as ~25% and as low as ~16%

[Supersixx]

I think Histogen is gonna be the answer .. Their definately going in the right direction. Results so far were promising compared to replicel. Can't wait til it hits the market. Just can't believe how histogen is being dogged here and they actually produced way more visual hair than replicel. Should be all praises especially when replicel disappointed so much but was highly defended here. Replicel would of killed (figure speech) for histogens results. And that was just safety trials. Lol . If exciting news is coming giving they previous release , I'm tuned in!!!!! More optimistic than last week and a little less skeptic. 51/49.

[neversaynever]

Originally Posted by Supersixx

I think Histogen is gonna be the answer .. Their definately going in the right direction. Results so far were promising compared to replicel. Can't wait til it hits the market. Just can't believe how histogen is being dogged here and they actually produced way more visual hair than replicel. Should be all praises especially when replicel disappointed so much but was highly defended here. Replicel would of killed (figure speech) for histogens results. And that was just safety trials. Lol . If exciting news is coming giving they previous release , I'm tuned in!!!!! More optimistic than last week and a little less skeptic. 51/49.

Agreed, its pretty impressive results from a single injection so far. Im not shiney bald anywhere on my head, YET. Anyone know if they are including shiney bald scalps in their phase 2 trial?

[Pate]

Originally Posted by neversaynever

Agreed, its pretty impressive results from a single injection so far. Im not shiney bald anywhere on my head, YET. Anyone know if they are including shiney bald scalps in their phase 2 trial?

Don't know for sure but I doubt it. They will try it on bald scalp eventually but for now they need results so they can secure funding, and everything we know about HSC points to it being more effective (and possibly only effective) on thinning hair.

Funny thing that I noticed reading their published paper is that there were actually FOUR injections in each of the four treatment sites (ie sixteen injections total). They keep talking about 'a single injection' but they must mean from a time point of view (ie no follow-up injection).

That also explains why the area responding to treatment looked bigger than 2mm radius. It's because there were actually multiple injections in a square pattern.

[BoSox]

Originally Posted by Pate

HSC points to it being more effective (and possibly only effective) on thinning hair.

How thin can the hair be in order for HSC to work? Do you think it will only work on hairs that are "just" beginning to thin, or ones that are barely visable.
I'm just concerned that the hairs that are thinning now will be damaged beyond repair by the time HSC is released.

What do you guys think?

[2020]

Originally Posted by BoSox

I'm just concerned that the hairs that are thinning now will be damaged beyond repair by the time HSC is released.

no such thing. Your hairs aren't "damaged". MPB has nothing to do with your immune system attacking them of anything. Your follicles are all there ready to grow, they just need a little help

[neversaynever]

Originally Posted by 2020

no such thing. Your hairs aren't "damaged". MPB has nothing to do with your immune system attacking them of anything. Your follicles are all there ready to grow, they just need a little help

Not to sure about that. Its confirmed that the stem cells are there, but noone has revived dormant follicles yet.

I dont know enough about the biology of it, but I remember seeing pictures of follicles at different stages, including the dormant phase. All the necessary components were there, but it just looked shriveled up.

If some scientists claim that all thats needed is the signal to tell the stem cells to get working, then here's hoping HSC can delivery that! Assuming its wnt signals and not something else.

It takes a very long time for a follicle to become dormant. From terminal, to thin, to velus, peach fuzz, and then it continues but the hair doesnt come through the skin. <<<<< If HSC can wake all those up then I'm saved. For the people who have been shiney bald for 5 years or more....who knows. It would be pretty stupid to only be testing it out on thinning patients, so I'm sure histogen will have 'some' news soon enough. They still doing a 3 month update?