Originally Posted by Gjm127
What's Cotsarelis doing now? I mean, he knows about this since 2007, why isn't he working on a making a drug for it?
It takes approx. 8 years to approve a drug, they haven't done dick yet... They'Re not even doing any trials or ANYTHING...
Cotsarelis works for Follica: http://www.follicabio.com/
I'm sure they're doing something but since it's a private company they have no obligation to reveal anything to us.... That patent probably raises the value of their company.
Originally Posted by clandestine
I'm sorry 2020, but this is a pretty wild assumption.
How in gods name did we go from blocking PGD2 as a potential viable treatment for arresting hair loss, to 'NW7 to NW1 no problem'? Surely I'm missing something?
because..... that study PROVES that PGD2 is inhibiting hair growth.
A mouse did not grow his hair back until they stopped applying PGD2 on his fur. A cultured human follicle was significantly shortened when exposed to PGD2.
PGD2 alone is the culprit. Not your immune system. Not the androgens.
The only reason PGD2 is there in the first place in non-balding people is to keep other prostaglandins in balance in order to prevent "overgrowth".
Unfortunately for us baldies, our body responds to the inflammation by overproducing PGD2 which then prevents hair from growing.
There has been reports from people who reversed their male pattern baldness by taking strong anti-inflammatories..... such drugs inhibit COX-2 which in turn lower levels of PGD2 so that's why it makes sense that it would work! Check out this thread:
about "NW7 to NW1" part: yes, your hair loss is completely reversible. Once you block PGD2 completely, the balance will be shifted to the good prostaglandins and slowly you will regrow everything.
Good prostaglandins grow hair as proven by minoxidil and latisse.
We found that in C57Bl/6J mice, the levels of prostaglandin synthases and their products (PGD2, PGE2, PGF2a) were reciprocally expressed during wound healing. PGE2 and PGF2a levels increased during the early phases of wound healing while PGD2 increased during the later stages of wound healing......
In all, these findings demonstrate that PGD2 inversely correlates with hair follicle regeneration implying that inhibition of PGD2 production or Gpr44 signaling pathways may promote skin regeneration.
another coincidence that increased levels of PGE2 and PGF2A has been able to regenerate follicles?
Originally Posted by WillhasWill
What a joke. Nothing you say is credible when you make assumptions like this. Cotsarelis finding shows a potential treatment but the finding didn't show a cure. Possibly might be with further work.
I see you didn't read the actual study ...