Bald Truth Talk - Hair Loss, Hair Transplant and Hair Restoration Community  

Go Back   Bald Truth Talk - Hair Loss, Hair Transplant and Hair Restoration Community > Men's Hair Loss > Hair Loss Treatments > Cutting Edge / Future Treatments
Register Blogs FAQ Members List Calendar Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 05-02-2012, 09:50 AM   #1561
Maradona
Senior Member
 
Maradona's Avatar
 
Join Date: Nov 2011
Posts: 830
Default

Total disaster, never expected such REALLY bad results and this is an overdose .

Time to get on fin, **** ! I'm scared.
Maradona is offline   Reply With Quote
Old 05-02-2012, 10:03 AM   #1562
lpenergy
Member
 
Join Date: Mar 2012
Posts: 60
Default

While I am hoping for the best from Replicel, I have to say that I am out as an investor until I see something that provides very positive results or a similar indication. I sold half of my position upon the announcement of the delay and the other half this morning. I got in at a decent price, so a relatively small loss isn’t that bad given what could have happened.

If the results were considered to be strong (>20%), they would have raised additional funds after the results, which would have resulted in a lower shareholder stock dilution. Because they are simply using DSC cells, I do not see how they can “tweak” a formula to produce better results.

I am looking forward to any interviews, and wish the best for Replicel. If something changes, I may get back on board with buying their stock, but not at this point. It is going to be long slow slog as far as an investment.

At this point, it seems that we have to hope for any of the following:

1) The site location on the temples was sub-optimal, other spots would perform better
2) 6 months was not enough time
3) Overdosing actually hurt the results,
4) Results are compoundable
5) The treatment is more effective at stopping/slowing hair loss instead of regrowth
6) It is an augmenting treatment option
So, David Hall needs to explain why they expect future results to improve. Why did they get the high percentage hair regrowth in animals and not humans?
lpenergy is offline   Reply With Quote
Old 05-02-2012, 10:05 AM   #1563
kaandereli
Member
 
Join Date: Jan 2012
Posts: 57
Default

http://www.replicel.com/wp-content/u...ED-655x426.png

50% growth on mice, 6% for human.it is damn frustrating
kaandereli is offline   Reply With Quote
Old 05-02-2012, 10:08 AM   #1564
BaldinLikeBaldwin
Senior Member
 
BaldinLikeBaldwin's Avatar
 
Join Date: Apr 2012
Posts: 222
Default

Believe both Replicel and the hair loss community are disappointed by these results. Oh, well..
BaldinLikeBaldwin is offline   Reply With Quote
Old 05-02-2012, 10:08 AM   #1565
Kirby_
Senior Member
 
Join Date: Jan 2012
Posts: 447
Default

Quote:
Originally Posted by UK_ View Post
You have to also remember that Replicel has not figured out 'dosing range' yet - this phase was primarily for safety, when they explore what dose works best I am sure we will see far better results.
Isn't the Phase I dose an overdose? (Correct me if I'm wrong, somebody!)
Kirby_ is offline   Reply With Quote
Old 05-02-2012, 10:18 AM   #1566
lpenergy
Member
 
Join Date: Mar 2012
Posts: 60
Default

Quote:
Originally Posted by Kirby_ View Post
Isn't the Phase I dose an overdose? (Correct me if I'm wrong, somebody!)
Yes, if they overdosed the mice and got 3% results, wheras if they gave the proper lower dosage and that resulted in +50%, then it is significant. Otherwise, we don't have a good reason for the variance.
lpenergy is offline   Reply With Quote
Old 05-02-2012, 10:22 AM   #1567
sausage
Senior Member
 
Join Date: Jan 2012
Posts: 1,062
Default

They say their results were positive, if its just 6% growth then in the bigger picture how is that positive?

Do they think it will grow loads of hair with in increased dose?
sausage is offline   Reply With Quote
Old 05-02-2012, 10:23 AM   #1568
oracle
Junior Member
 
Join Date: Oct 2011
Posts: 10
Default

Quote:
Originally Posted by Kirby_ View Post
Isn't the Phase I dose an overdose? (Correct me if I'm wrong, somebody!)

I think it is a range of high to low doses. What results did the high doses show?
I'd guess there where 4 or 5 levels in the whole range. Subjects at the high end of the range may show better results. With only 19 subjects, there's not much significance to be drawn on from these results in terms of efficacy.
oracle is offline   Reply With Quote
Old 05-02-2012, 10:25 AM   #1569
WillhasWill
Member
 
Join Date: Mar 2012
Posts: 59
Default

Quote:
Originally Posted by Kirby_ View Post
Isn't the Phase I dose an overdose? (Correct me if I'm wrong, somebody!)
Where have Replicel said they overdosed on this trial? How can they overdose when they do not know the optimal dosage yet?

No dosages have been defined, they are only in phase 1 of clinical trials. Are people confusing an overdose with dose ranges?
WillhasWill is offline   Reply With Quote
Old 05-02-2012, 11:10 AM   #1570
tonypizza
Member
 
Join Date: Jul 2011
Posts: 42
Default

Why don't they try injecting human hairs onto immunologically neutralized mice, then transplanting the hairs onto human scalps.

If everyone keeps trying the same thing it'll be decades before they finally realize the human scalp is only good at fostering growth of hair follicles at a young age. Something changes as we get older, and the environment is not good for growth of new follicles. That's why these treatments work like magic on mice, but not humans.

Farm the follicles on mice or pigs, and transplant them
tonypizza is offline   Reply With Quote
Reply

Tags
replicel, replicel: last hope, replifail, treatment

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump

» The Bald Truth
» Recent Threads
8th World Congress For Hair Research - Korea (2014)
03-04-2014 01:52 AM
Last post by Arashi
Today 03:18 PM
Hair loss best thing that ever happened to me.
03-30-2014 07:49 PM
Last post by Notcoolanymore
Today 03:08 PM
» Newest Videos

Update On Hairloss 8/10/09...
My hair loss was getting worse, so I just got it cut really short now. I don't think it looks that b...


Hair Loss Remedy Myths Perpetuated Onlin...
We are sure these people mean well, but this is a prime example of why the snake oil industry thrive...


Hair Transplant | "SurgeonofNalts&q...
http://www.baldtruthtalk.comFounder of The American Hair Loss Association Spencer Kobren speaks with...


How Hair Loss Colors Our Lives | Spencer...
...


All times are GMT -7. The time now is 06:23 PM.