Dr Nigam, my own experience

[veca]

Yeah Mario, if Histogen, Replicel or Aderans ever come out we will need over 1000 injections to cover the NW5 area!

I know some patients received those numbers in the Intercytex trials, which is scary to say the least...no pain no gain!

I'd do it though if it proves to be safe though...half an hour of suffering for a decade of happiness

Desmond84, what do you think about the safety of Dr. Nigams procedure?

[mari0s]

Yeah Mario, if Histogen, Replicel or Aderans ever come out we will need over 1000 injections to cover the NW5 area!

I know some patients received those numbers in the Intercytex trials, which is scary to say the least...no pain no gain!

I'd do it though if it proves to be safe though...half an hour of suffering for a decade of happiness

Hi, nor Tom nor Wesley have spoken about this number so i was curios of how many have actually taken. :P
I wish it would be required only half an hour but i'm afraid at least two days. Replicel have develop a new kind of syringe but i don't know if could be really useful in this kind of matter.

http://rls.redrocketblastoff.com/product-pipeline/rci-02-injector/

About safety, here in Italy a huge mess happen when Stamina Foundation has been allowed to use mesenchymal cells from bone marrow, so far no one showed problems of any kind. Replicel and aderans use mesenchymal cells form DP which have proven to be safe so far (they have more than 10 years of trials on their back)

About the patent i've linked i have noticed that has been registered more than 2 yrs ago under Alvi Armani who is (was?) a HT surgeon and show a complete temporal restoration (in terms of quantity, i don't know about density) so why they don't have never offered to their patients? Maybe the HT business is more profitable, we should remember before start complain about Nigam every time

[Arashi]

So Tom, on HS, you stated that Dr Nigams was 'too busy' to make pictures. Can you maybe shoot some pictures yourself then of your recipient and post them ? Thanks !!

[Boldy]

so why they don't have never offered to their patients? Maybe the HT business is more profitable, we should remember before start complain about Nigam every time

Indeed mari0s, the thing is, why would you invest, and take ricks, if you have already a successful running clinic? regarding arvid, he has a very successful clinic line, nigams, has already 2 full clinics with 6-8 patients per day, however he still invests allot in improving the current techniques.

People don't seem to see this fact.

3d culture is to time consuming(the process would be approximately 8-10 weeks per patient), calculated per hour, its much smarter to make money with a HT... very sad that. the business are there just for money.. something we should not forget.



also, not to forget, in india you wont have the regulations issues, that you have in europe/us.

I have received my pics from nigams, and I think I will have time today to make my post, about my temporal hairline restoration, we used some different approach, than what he used to its a experiment that looks good so far.


Boldy

[tom vercetti]

Tom just of curiosity how many injections did you take? I was reading on this patent
http://www.google.com/patents/US20110305671 that in their protocol the made until 100 injection for cm2!! (i was so naive to think it would be at max 1 for cm2)

assuming 10 injections for cm2 and a scalp of 80cm2 we talk of 800 injections and more, to be onest the numbers is quite scared.

"In one aspect of the invention, the number of injections is 5 to 100 injections per square centimeter of the scalp, optionally 10 to 50 injections per square centimeter. In another aspect, 10 or 15 injections per square centimeter are performed. In another aspect of the invention, up to 50 or 60 injections per square centimeter are performed"

I dont know how much.. cant say.. ith such a protocol you are "half sleep" as you know.. But it was a lot and slowly injected. The patent dont learn us anything.. they just took a large range.

Actually I feel also very concern about the injection protocol, especially for the dp if there is a specialist in pharma here maybehe can give his mind about is it possible to make a vehicule and then reach a large area every injection.

Any idea desmond ?

@Arashi, yes for sure, I will post macro pics as you want no problem. But result is the same than before.

[Desmond84]

Desmond84, what do you think about the safety of Dr. Nigams procedure?

In terms of safety, there are TWO concerns:

1) Safety of DP cells expanded in culture and reintroduced in the dermal layer: as Mario mentioned the 2D DP expansion method has been tested in humans by Intercytex and Aderans since 2004 with no serious adverse events reported and both companies managed to finish both their Phase 1 and 2 trials without any major concerns...which is GREAT NEWS The jury is still out there on the 3D spheroidal method

2) Safety of Dr Nigam's DP expansion: This is where Boldy's expertise come into play...when dealing with Biological therapies 60% of a therapy's efficacy and risk of side effects is based on method of manufacture! As long as we can be assured by Boldy (and hopefully other Doctors such as Dr Cole) that Dr Nigam's laboratory is state of the art with up to date GMP and GLP practices then we can be almost certain that there is NOT much risk of doing it in Mumbai! The "Good Manufacturing Practice" and "Good Laboratory Practice" guidelines have just been updated to include manufacturing of biologicals which is a very complex process, where slight changes in storage or culturing method may lead to a completely different final product.

About the patent i've linked i have noticed that has been registered more than 2 yrs ago under Alvi Armani who is (was?) a HT surgeon and show a complete temporal restoration (in terms of quantity, i don't know about density) so why they don't have never offered to their patients? Maybe the HT business is more profitable, we should remember before start complain about Nigam every time

How sad is this! But don't worry guys, if the science is right and it actually works, it will happen one way or another...

Indeed mari0s, the thing is, why would you invest, and take ricks, if you have already a successful running clinic? regarding arvid, he has a very successful clinic line, nigams, has already 2 full clinics with 6-8 patients per day, however he still invests allot in improving the current techniques.

People don't seem to see this fact.

3d culture is to time consuming(the process would be approximately 8-10 weeks per patient), calculated per hour, its much smarter to make money with a HT... very sad that. the business are there just for money.. something we should not forget.


also, not to forget, in india you wont have the regulations issues, that you have in europe/us.

I have received my pics from nigams, and I think I will have time today to make my post, about my temporal hairline restoration, we used some different approach, than what he used to its a experiment that looks good so far.


Boldy

Dr Nigam's efforts should be watched very closely...it is the most interesting story to happen in the past 5 years at least!

I personally love his charismatic attitude...time will also tell if his efforts will work...the 3D DP culturing combined with beard DP culturing is a radical idea that definitely points to the fact that he's here to be taken seriously and wants to offer something better!

And I say, good on this guy...let's give him a chance and not de-fame him before he even gets a chance to produce the results...

July 2014 will be make or break for a lot of these upcoming treatments such as Replicel, CB-03-01 and most probably Dr Nigam's efforts...

We just have to be patient once more and see what comes of these efforts.

I dont know how much.. cant say.. ith such a protocol you are "half sleep" as you know.. But it was a lot and slowly injected. The patent dont learn us anything.. they just took a large range.

Actually I feel also very concern about the injection protocol, especially for the dp but we would need to

Any idea desmond ?

Tom...Aderans came up with a refined technique for injection of DP cells and got their "pen" system approved! I think you can even purchase it....let me do a bit of research...I'll get back to you

[Desmond84]

Oh also Tom could you please take a lot of photos NOW or in the next few days, so we can see if these injections had any effect in the next few months! And btw I didn't get to say this before, thank you so much for all your efforts brother...I have a lot of respect for ppl like you and Boldy who are actually trying actively to find a cure rather than sitting at home sobbing over this mess!

I'm wishing you the very best and really hope these treatment protocols work out

Looking forward to seeing your mohawk brother

[veca]

Indeed mari0s, the thing is, why would you invest, and take ricks, if you have already a successful running clinic? regarding arvid, he has a very successful clinic line, nigams, has already 2 full clinics with 6-8 patients per day, however he still invests allot in improving the current techniques.

People don't seem to see this fact.

3d culture is to time consuming(the process would be approximately 8-10 weeks per patient), calculated per hour, its much smarter to make money with a HT... very sad that. the business are there just for money.. something we should not forget.



also, not to forget, in india you wont have the regulations issues, that you have in europe/us.

I have received my pics from nigams, and I think I will have time today to make my post, about my temporal hairline restoration, we used some different approach, than what he used to its a experiment that looks good so far.


Boldy

Boldy I appreciate your knowledge and expertise in this field of medicine. You were at the clinic with Dr. Nigam, you've seen it all, and you're part of the process. Can you give me your odgovoiti a question regarding the safety of the procedure. Are there side effects or a big or a small risk? Thank you in advance for your reply;-)

[Boldy]

Boldy I appreciate your knowledge and expertise in this field of medicine. You were at the clinic with Dr. Nigam, you've seen it all, and you're part of the process. Can you give me your odgovoiti a question regarding the safety of the procedure. Are there side effects or a big or a small risk? Thank you in advance for your reply;-)

the head Lab worker is a talented professional without doubts. and the protocols and guidelines don't differ from Europe. the lab seme to be under supervision of the fda that checks regular there.

regarding safety its a hard questions. my believe everything, every medicine has its risk. The things we know is that mesenchymal dermal cells are extensively tested on human around the world without known sides (as fare literature describes).autologous (your own cells), expanded, and dose depended injected back. that latter part should be done with full caution of course.


the difference between 2d/3d culture = that 3d comes nearby vivo environment. cells can feed each other with signals and can maintain this way their instinctive properties.


You will not hear me say cell therapy is 100% safe. that is not possible. that's the same like I would say the following: paracetamol is safe for everyone. that is simply not true, there are always people who have adverse effects from that drug or even worse.

the good thing, I have noticed, first day I arrived at nigams, even before discussing the procedure what I wanted, like ht, doubling or hm, they took a full blood for analyses.. its at least something, they check the blood levels beforehand.


My word is cell therapy remains experimental at this date, and experimental means we have no certainty. even companies that pass all the 3 trial phases, it says not everything. there is no guarantee, however, I think cell therapy will be more and more a solution for various diseases in the future. its called regenerative medecine. http://en.wikipedia.org/wiki/Regenerative_medicine

[veca]

the head Lab worker is a talented professional without doubts. and the protocols and guidelines don't differ from Europe. the lab seme to be under supervision of the fda that checks regular there.

regarding safety its a hard questions. my believe everything, every medicine has its risk. The things we know is that mesenchymal dermal cells are extensively tested on human around the world without known sides (as fare literature describes).autologous (your own cells), expanded, and dose depended injected back. that latter part should be done with full caution of course.


the difference between 2d/3d culture = that 3d comes nearby vivo environment. cells can feed each other with signals and can maintain this way their instinctive properties.


You will not hear me say cell therapy is 100% safe. that is not possible. that's the same like I would say the following: paracetamol is safe for everyone. that is simply not true, there are always people who have adverse effects from that drug or even worse.

the good thing, I have noticed, first day I arrived at nigams, even before discussing the procedure what I wanted, like ht, doubling or hm, they took a full blood for analyses.. its at least something, they check the blood levels beforehand.


My word is cell therapy remains experimental at this date, and experimental means we have no certainty. even companies that pass all the 3 trial phases, it says not everything. there is no guarantee, however, I think cell therapy will be more and more a solution for various diseases in the future. its called regenerative medecine. http://en.wikipedia.org/wiki/Regenerative_medicine

Thank you for your response, I appreciate it.

[DepressedByHairLoss]

Hi, nor Tom nor Wesley have spoken about this number so i was curios of how many have actually taken. :P
I wish it would be required only half an hour but i'm afraid at least two days. Replicel have develop a new kind of syringe but i don't know if could be really useful in this kind of matter.

http://rls.redrocketblastoff.com/product-pipeline/rci-02-injector/

About safety, here in Italy a huge mess happen when Stamina Foundation has been allowed to use mesenchymal cells from bone marrow, so far no one showed problems of any kind. Replicel and aderans use mesenchymal cells form DP which have proven to be safe so far (they have more than 10 years of trials on their back)

About the patent i've linked i have noticed that has been registered more than 2 yrs ago under Alvi Armani who is (was?) a HT surgeon and show a complete temporal restoration (in terms of quantity, i don't know about density) so why they don't have never offered to their patients? Maybe the HT business is more profitable, we should remember before start complain about Nigam every time

Wow Mario, are you saying that Dr. Armani has a method to restore temporal hair regrowth at the cellular level yet is just sitting on this patent and not doing anything to essentially bring a much improved hair regrowth method to hair loss sufferers?

[hellouser]

Wow Mario, are you saying that Dr. Armani has a method to restore temporal hair regrowth at the cellular level yet is just sitting on this patent and not doing anything to essentially bring a much improved hair regrowth method to hair loss sufferers?

This is definitely something that should be on our radar!!!!

Desmond, comments?!

[mari0s]

Wow Mario, are you saying that Dr. Armani has a method to restore temporal hair regrowth at the cellular level yet is just sitting on this patent and not doing anything to essentially bring a much improved hair regrowth method to hair loss sufferers?

The patent show a +114% of regrowth, with a hair density passing from 100 to over 200 hair for cm2 (the average density in a scalp not affected from aga).
Of course there could be other reasons to not be doing anything, maybe the majority of new hair were vellus or could be related to the fact that Armani was force to resign is licence due to unethical reasons, who knows

[hellouser]

The patent show a +114% of regrowth, with a hair density passingo from 100 to over 200 hair for cm2 (the average density in a scalp not affected from aga).
Of course there could be other reasons to not doing anything, maybe the majority of new hair were vellus or could be related to the fact that Armani was force to resign is licence due to unethical reasons, who knows

Where are you seeing this patent and those numbers? Do you have a link?

[DepressedByHairLoss]

Yeah, I'd love to see a link for the patent and those outstanding numbers. Matter of fact, I think this patent/discovery deserves a thread of its own.