Dermarolling Community Trial

[Hicks]

It would be nice to have all the pics in one place, so they could be collated into one .pdf file that anyone can download.

We could set up a free cloud storage account or use something like photobucket. Them each participant would upload the pics with stirct file naming of the photos. Something like...

• Brunobald_Base_line.jpg
• Brunobald_Wk3.jpg
• Brunobald_Wk6.jpg
• Brunobald_Wk9.jpg

and so on

This means someone can opt to do the job of creating a document with all the results and it would be easy to find and arrange in the correct order, without having to go through this whole thread and download each one.

+1 for this, I don't have time to filter through these threads then hit 2 pages of off topic. I'll continue to document on my own but if something interesting pops up I'll post.

Maybe even create a Thread of week 3 dermarolling results, then another NEW thread of week 6 results. would be even nicer if someone can post the result and everyone else doesn't start debating the results.

[Conpecia]

+1 for this, I don't have time to filter through these threads then hit 2 pages of off topic. I'll continue to document on my own but if something interesting pops up I'll post.

Maybe even create a Thread of week 3 dermarolling results, then another NEW thread of week 6 results. would be even nicer if someone can post the result and everyone else doesn't start debating the results.

I agree with this.

We can chat here, but let's create a Week 3 Dermarolling Results thread with just posts, then a Week 6, Week 9, etc. Great idea.

[sosa56]

The study show that you need to clean the scalp with Betadine and Saline solution. I am doing that. Betadine and Saline solution is cheap and easy to apply. That way you prevent any possible infection or follicle inflammation.

Where do you get your betadine and saline solution, how much do you apply and does it not stain the scalp? Is anyone else using betadine and saline before needling?

Hellouser are you using betadine and what are your views on it's necessity for the effectiveness of the procedure (i.e. if one doesnt use it then one will get micro infections in the follicles thereby causing 'bad' inflammation and negating the effects of the dermarolling as the poster above seems to suggest - surely you'd be able to tell if you had a scalp infection, isnt the betadine just applied to prevent an infection from the dermarolling?)?

[hellouser]

Where do you get your betadine and saline solution, how much do you apply and does it not stain the scalp? Is anyone else using betadine and saline before needling?

Hellouser are you using betadine and what are your views on it's necessity for the effectiveness of the procedure (i.e. if one doesnt use it then one will get micro infections in the follicles thereby causing 'bad' inflammation and negating the effects of the dermarolling as the poster above seems to suggest - surely you'd be able to tell if you had a scalp infection, isnt the betadine just applied to prevent an infection from the dermarolling?)?

I can say with certainty that my scalp is pretty itchy lately, and had a burning sensation for the next 24 hours after my last dermarolling solution. I don't use anything after dermarolling, i leave the skin as is and go to bed. I do use isopropanol to clean my dermaroller.

As a side note, I've been shedding a LOT in the last few days. Not sure why. I did drop RU a few months ago, and have been shedding for about a month regardless.

[sosa56]

I can say with certainty that my scalp is pretty itchy lately, and had a burning sensation for the next 24 hours after my last dermarolling solution. I don't use anything after dermarolling, i leave the skin as is and go to bed. I do use isopropanol to clean my dermaroller.

As a side note, I've been shedding a LOT in the last few days. Not sure why. I did drop RU a few months ago, and have been shedding for about a month regardless.

No but in the study protocol it says that betadine is used before the rolling to prepare the scalp

[Hicks]

Where do you get your betadine and saline solution, how much do you apply and does it not stain the scalp? Is anyone else using betadine and saline before needling?

Hellouser are you using betadine and what are your views on it's necessity for the effectiveness of the procedure (i.e. if one doesnt use it then one will get micro infections in the follicles thereby causing 'bad' inflammation and negating the effects of the dermarolling as the poster above seems to suggest - surely you'd be able to tell if you had a scalp infection, isnt the betadine just applied to prevent an infection from the dermarolling?)?

I was wondering the same. Does betadine stain? Saline solution I just put some in my hair. The goal is to disinfect your scalp. After I rollered I used coconut oil. I used coconut oil because that's what I had.

[hellouser]

Theres an AWESOME contribution to the wounding theory on Hair Loss Talk from a member by the name of 'princessrambo'

I think timing is critical when introducing an anti-inflammatory.

Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44

These results imply a regulatory network in hair follicles wherein PGD2 inhibits, whereas PGE2/F2a promote, hair follicle function.
PGs are key inflammatory mediators involved in wound. We also found that during wound healing, the capacity of tissue to generate PGE2 and PGD2 is separated over time, thus providing evidence consistent with the distinct functions of PGs. These results are similar to those observed after incisional wound healing in DBA/I mice (Kapoor et al., 2007). In C57Bl/ 6J and DBA/I strains and models of wound healing, PGE2 is the more abundant product during the early phases of wound healing. Elevated levels of PGE2, a potent immune activator, are consistent with progressing inflammation (Sakata et al., 2010). Whereas, at later stages, when inflammation is resolving, PGE2 levels taper off and PGD2 becomes the predominant PG.

Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44

Now let's look at the charts provided in the study, specifically picture d,



We can clearly see that the critical point is day 5 when PGD2 starts to rise after wounding and day 8 is when the good prostaglandins PDGE/F start to dwindle and they seem to go back to their "baseline" levels (for us boldies, that mean pdg2 probably back to its f****g MPB level ) at day 15-ish.

I think that is (day 5 and after) where you should aim with your nizoral, PGD2 blocker (possible topical EGCG, Resveratrol, etc) and keep boosting fgf9 through PGE2 (possibly minox, castor oil, etc). I also think such treatment pattern is at the heart of follica's recent patent for hair loss. I would also add calcipotriol throughout the whole process to keep boosting Wnt throughout the cycle, i've had incredible amount of brand new terminal hair using it (diffuse pattern filling in), and i decided to combine it with the cheese grater thingy. The study posted in this thread used 7 day cycles and they got somewhat decent results but looking at the studies, It seems critical (from what i have researched) to keep longer windows between wounding sessions, I would personally advocate 10 days to two weeks minimum, as to not keep the scalp in a constant state of pro-inflammation and allow full cycle WIHN. I do believe that extensive wounding is necessary, like serious bad S**t crazy bleeding with no less than a 1.5mm grater

Link to thread: http://dft.ba/-princessrambo-wounding

[chimera]

So, If we keep wounding once a week, would that keep the PGD2 low and the PGE high?

[the_dude78]

Theres an AWESOME contribution to the wounding theory on Hair Loss Talk from a member by the name of 'princessrambo'



Link to thread: http://dft.ba/-princessrambo-wounding

Great find, Hellouser! Very interesting.

[GreyGhost1864]

I am going to do it once a week for the first 12 then go to every 10 days. Will add the calcipatrol she speaks of. Spelled wrong. Scared to take a pic but I can tell you I feel fur in my crown. Can I get a amen. Close gents.....results in numbers! Ideas no lab FDA bs!
Ghost

[TO YOUNG TO RETIRE]

i feel excited about it, cant wait for results guys. do you think we solve the curse?

[hellouser]

i feel excited about it, cant wait for results guys. do you think we solve the curse?

Given that the guy that had the burned scalp and regrew everything in that area... I think its absolutely *POSSIBLE* but we're still some steps away... as in; how deep do we wound? how often? when do we add minox? how much minox? should we inhibit anything else? does skins thickness play a role?

There are probably more questions we haven't yet asked that would answer this dilemma further.

[Conpecia]

that's a damn good post. maybe i'll start by doing it every other week instead of every week.

[brunobald]

Threads like that one just posted are another reason why we need a central website/forum concentrated on curing MPB. There are nuggets of golden info and conversation littered over several forums. If we can bring our minds together we can be far more effective than any single lab on earth. This is what the internet does so well. We are not fueled by the promise of money but a passion for advancing our treatment, something far more driven than a hired gun in a research lab. Sorry for going off topic but the potential of every guy and girl who is pissed off by hairloss contributing to a project like this is very exciting.

[clandestine]

Given that the guy that had the burned scalp and regrew everything in that area... I think its absolutely *POSSIBLE* but we're still some steps away... as in; how deep do we wound? how often? when do we add minox? how much minox? should we inhibit anything else? does skins thickness play a role?

There are probably more questions we haven't yet asked that would answer this dilemma further.

Link to thread with guy who had burned scalp and regrew?