Histogen Update - Spencer Kobren Speaks With Dr. Craig L. Ziering

But right now there isnt much else to say they did test if HSC could be dangerous, and it isnt.

They saw hair still be there after two years and now they gonna for different approches after 6 weeks etc which is exactly according to plan.

I dont think that it was all happy talk, it was a realistic observation from someone at the source.

The most important thing is, its safe AND the hair stays, who knows what can be achieved with higher injections here and there. At least from the data it could hairtransplants make more sufficient with less grafts to plant.

Also the idea about Histogen in the first round to stop hairloss and grow back special parts and then go for Acell orientated hair transplant is pretty damn good.

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Originally Posted by RichardDawkins

But right now there isnt much else to say

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My point exactly. No substantive information is not exactly something to be optimistic about.

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it was a realistic observation from someone at the source

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But someone who also has a vested interest in making things seem as positive as possible.

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The most important thing is, its safe AND the hair stays

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Neither of those factors has been established yet.

First of all, early stage clinical trials seek to determine whether a particular treatment manifests any immediately obvious deleterious effects serious enough to warrant discontinuation of the trials. If if doesn't, then the trials can proceed, but that milestone is very far from demonstrating that a treatment is "safe" in an overall sense. Safety is something which can only be determined with much wider trials, a much larger user base, and the passage of time (as numerous recalls of previously approved drugs have demonstrated).

Second, any trial of a treatment for regrowing hair would realistically have run at least two years (and possibly longer) just to determine whether the new hairs produced by the treatment survive an anagen/telogen cycle. Even then, you don't know for sure -- a newly produced hair might survive the first cycle, but that's no guarantee it won't, say, (akin to miniaturization) grow progressively weaker and fail to survive subsequent cycles. What the long term benefits or effects will be are something that can only be determined in the long term, and obviously none of us here is going to be able to wait a couple of lifetimes to verrify how things pan out.

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Originally Posted by gmonasco

My point exactly. No substantive information is not exactly something to be optimistic about.



But someone who also has a vested interest in making things seem as positive as possible.



Neither of those factors has been established yet.

First of all, early stage clinical trials seek to determine whether a particular treatment manifests any immediately obvious deleterious effects serious enough to warrant discontinuation of the trials. If if doesn't, then the trials can proceed, but that milestone is very far from demonstrating that a treatment is "safe" in an overall sense. Safety is something which can only be determined with much wider trials, a much larger user base, and the passage of time (as numerous recalls of previously approved drugs have demonstrated).

Second, any trial of a treatment for regrowing hair would realistically have run at least two years (and possibly longer) just to determine whether the new hairs produced by the treatment survive an anagen/telogen cycle. Even then, you don't know for sure -- a newly produced hair might survive the first cycle, but that's no guarantee it won't, say, (akin to miniaturization) grow progressively weaker and fail to survive subsequent cycles. What the long term benefits or effects will be are something that can only be determined in the long term, and obviously none of us here is going to be able to wait a couple of lifetimes to verrify how things pan out.

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Well if you already knew all the answers, why are you disappointed? I doubt you will have to wait a LIFETIME homie so don't worry about that ha. So what if the hair wont survive the cycle? If it grew it in the first place, then get another injection. I think its pretty obvious that we still don't know shit about it but i do know we wont have to wait a couple of lifetimes to find out. We will know soon enough.

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Originally Posted by ZM4HAIR

Right now Singapore but possibly Korea as well.

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I know you spoke about the 2 year trials so far and how hairs were still present after that time. If histogen does not do much as far as growth for some, will it at least guarantee no further hair loss? Did you notice this in pre trials?

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Originally Posted by CVAZBAR

Well if you already knew all the answers, why are you disappointed? I doubt you will have to wait a LIFETIME homie so don't worry about that ha. So what if the hair wont survive the cycle? If it grew it in the first place, then get another injection. I think its pretty obvious that we still don't know shit about it but i do know we wont have to wait a couple of lifetimes to find out. We will know soon enough.

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You might find this system works best if you actually take the time to read and comprehend material prior to responding to it.

everything sounds interesting but if 2013-2014 wasnt mentioned as potential dates this is very frustrating :s

Thanks Dr. Ziering for posting replies to all our questions. That's pretty awesome of you. I'm really looking forward to hearing and seeing more from histogen!

-Max

Thanks for answering my question Dr. Ziering, this is by far the best and most informative hair forum on the internet!!! When I read some of the other ones it all posts based on speculation from people who really have no clue what’s going on.

One more thing doctor if you don’t mind, do you think a person who’s approaching a Norwood 5 or 6 can be helped with Histogen?

Thank you:)

Hello Dr. Ziering.

I got an email from gail naugton last month saying "We are starting phase 1/2 in Singapore before the end of May and hope to have phase 3 pan-Asian data by Sept 2012 for an NDA submission and 2013 approval. (hopefull Q2 2013)."

Is it possible that the NDA submissions could be shortened? Does it have to be 6-12 months long?

Is it possible to lobby the Singapore Health Authority to shorten it?

Are the new hairs from the HSC injections colored hair, for a person with greying hair?

For example if a person has white hair (ie anderson cooper) will the new grown hairs from HSC injections be white or black?