Aderans - clinical trials

[Sogeking]

So I've been reading a thread from a site we can't discuss here opened by Spanish Dude. It seems he has stumbled upon information about current clinical trials of Aderans. My thanks to him for this find.
There are 10 of them listed. 4 of them are completed. 6 still running. One of them is a trial being run together with Minoxidil.
http://clinicaltrials.gov/ct2/results?term=Aderans

Total: 345 trialists.

Very good news: only 43 trialists received Minoxidil (3rd entry)!!

There seems to be 6 different "Ji Gami" formulas:
Ji Gami
Ji Gami DO
Ji Gami N
Ji Gami NDO
Ji Gami C
Ji Gami CN

It seems Aderans has been working alot. The last trial was started in July and will in end in February of 2013.


My opinion:
This is a good way to conduct trials. And trialists are in great number. I am starting to take Aderans in consideration for a possible new treatment. Let us see what happens....

[DepressedByHairLoss]

I was about to participate in their Phase II trial in the summer of 2010 but then I heard that they didn't have that great of results. And if they have to do a biopsy, I wanna make damn sure that I get some great results. What's good is that we have Histogen, Replicel, and Follica giving them plenty of competition, so I guess that would give them the kick in the pants that they might need to get the trials going into high gear and get something out to us as quick as possible. Heard they recently got a $100 million investment to move forward. They've really gotta come up with something!

[RichardDawkins]

Well good for them. If they abandon this Ji Gami with Minoxodil Mix in the next update they are really onto something

[DepressedByHairLoss]

I agree Richard. One of the main positives of these new treatments would be that wouldn't need to work about taking minoxidil and finasteride every day.

[RichardDawkins]

Thats what they are aiming for because if they come up with something where you have to take Fin or Mino......well i dont think that people would rush their offices for a slightly better Minox.

But one thing should give us really something to think, right now ALL involved with hair multiplication, replicel, ari, gho and others are not in favor of Minox and FIN, which is actually good for us.

Well i cant say for ure, but i think that this time a cure is more then just possible and the most important thing here is that it can be affordable because hey what if you have a cure but it will take your more then 50.000 US dollar for example?

And sorry even with Jotronic and his remarkable transplant, i still dont believe anymore in simple FUT, nor do i believe in simple FUE.

I dont know the hair transplant world 10 years ago, i wasnt there, but i dont think that a lot of groundbreaking discoveries have been made back then, i simply doubt it.

Today we almost get a weekly update where some researcher has found something and the pauses between possible market entries are becoming smaller and smaller.

Almost no one is talking about 2020 or later, cough cough except Rassman guys. People are more like "plausible 2014".

And the thing is, all those reaearch effort are pointing towards one thing " cells" and "tissue engineering" and they simply dont point in a lot of different directions like "masturbation" "greasy scalp" or whatever, if you know what i mean

[stillinHS1994]

What? U still don't believe the "science" between beating off and hair loss? C'Mon everyone knows for a fact if you stop whacking it you'll keep your hair for decades to come lol wat a joke

[Sogeking]

I hope this stuff Ari, Replicel, Histogen, some of them, have something, and their product comes to market soon. The worst thing is the wait.

[Cory]

I hope this stuff Ari, Replicel, Histogen, some of them, have something, and their product comes to market soon. The worst thing is the wait.

But nothing in them screams cure, Ari only managed achieve 50% density, Replicel with animals also 50% and Histogen 25% with single injection, I guess we will have to wait they go further in trials and of course some news from Follica would be good.

You have, who knows how many articles about hair loss but still they don't know how to get you hair back, can we be that dumb?

[melwou7245]

Just out of curiosity, are any of the aforementioned treatments one of those where they pluck hairs and grow follicles around them before reinserting it into your scalp? They should be able to give you any density you want, however I'm pretty sure that will probably be the most expensive thing ever. If it's injections into your scalp, I can dig that, but taking your own stem cells, won't that lead to premature aging? :P

[Sogeking]

But nothing in them screams cure, Ari only managed achieve 50% density, Replicel with animals also 50% and Histogen 25% with single injection, I guess we will have to wait they go further in trials and of course some news from Follica would be good.

You have, who knows how many articles about hair loss but still they don't know how to get you hair back, can we be that dumb?

Actually the effects might be compundable. There is nothing to stop you form taking multiple injections. Also the hair that is regrown sould be there to stay. And lastly it might make a good prevention for those to come. Also even if you are a NW5 you take this treatment you stop at NW5 gain some hair regrowth and look for some HT just to get more density. HTs are simpler when you are NW5.


Sure these are speculations.But hope makes me happier. I do however agree these are only interim treatments. The next step is growing hair in Petri dishes and multiplying them. Basically HM. When will that come?
Not soon unfortunately. However even these future treatments are a better option than those available now.

Originally Posted by melwou7245
If it's injections into your scalp, I can dig that, but taking your own stem cells, won't that lead to premature aging? :P
Don't know 'bout that. :D

[GreatSage]

What? U still don't believe the "science" between beating off and hair loss? C'Mon everyone knows for a fact if you stop whacking it you'll keep your hair for decades to come lol wat a joke

Whats the science behind it?

[uninformed]

Whats the science behind it?

pretty sure its science from the school of sarcasm :)

[DepressedByHairLoss]

But nothing in them screams cure, Ari only managed achieve 50% density, Replicel with animals also 50% and Histogen 25% with single injection, I guess we will have to wait they go further in trials and of course some news from Follica would be good.

You have, who knows how many articles about hair loss but still they don't know how to get you hair back, can we be that dumb?

Actually, I think Replicel actually achieved 100% density in animals each and every time. Histogen I think managed more than 25% density, but they were only testing safety, and once they try compoundable results and higher dosages of HSC Complex, then that number will surely go up. I don't think Aderans's numbers were that great, but now that they know that they've got other companies on their tail to produce an effective solution for hair loss, they've just received a 100 million dollar investment to kick their product up a notch. I've got to think that one of these will be an effective solution. I've got to think that way because a life without hair is not a life I'm prepared to live.

[Ronin]

What do we actually mean by 100% density? 100% in relation to what? Is it a certain number of hair in a given cm^2?

[stillinHS1994]

I think its in relation to 190 hairs a cm^2 because that's the average for a normal non balding human or somethin...Idk though just a guess

[Sogeking]

You got something mixed up. I think Replicel got 50% density of hair regrowth in all of mice. Meaning 100% succes of 50% regrowth in mice.
Which, if by some wonder translates to humans would be unbelivable and would probably solve all of our problems. However we will see about that.

[Reece]

Have we ever been this "close" before? I am fairly new to the hair loss community (26 NW 2.5 and moving fast). I don't know if this is the kind of hype that propecia brought about or if it was always advertised as "10% growth". Some of these companies have been working on these formulas for over a decade, I just don't know if they ever hyped trial results as they are now.

I am trying to be careful to not get too excited and anticipate the best case scenarios. It seems that if these results only show very minimal progress than we may be back to the drawing board and another waiting game. Trying to stay optimistic though.

[uninformed]

Have we ever been this "close" before? I am fairly new to the hair loss community (26 NW 2.5 and moving fast). I don't know if this is the kind of hype that propecia brought about or if it was always advertised as "10% growth". Some of these companies have been working on these formulas for over a decade, I just don't know if they ever hyped trial results as they are now.

I am trying to be careful to not get too excited and anticipate the best case scenarios. It seems that if these results only show very minimal progress than we may be back to the drawing board and another waiting game. Trying to stay optimistic though.


not sure how you can hype trial results when companies are either waiting on results or show exiating data. results are pics and numbers for everyone to see you cant 'hype' them

[RichardDawkins]

Uninformed your nick speaks volumes, Just shut it there comes nothing of value from guys like you except bickering nd crying

[uninformed]

Uninformed your nick speaks volumes, Just shut it there comes nothing of value from guys like you except bickering nd crying

Just when I thought you are starting to recover from your fall from grace, the dorkins within is back.

I am just saying companies can't afford to create expectations they can't meet and I am apparently bickering and crying trololololol. Maybe you should clean up your own acts before you speak.

[Reece]

Didnt mean to stir up any bickering and I suppose i should of clarified that the hype for "potential" results is primarily from the hair loss community.

My question was more have ever been this "seemingly" close? I realize that there is no official human evidence yet but I am wrong to be a bit excited about the potential?

[RichardDawkins]

Well thats debatable but to be honest i think that they already tested a lot of stuff on human.

In one interview with SK there was one Replicel guy who had one minor thing slipped over his tongue

"The results on humans... ahhh mice were good so far"

Its like this 9/11 thing " Well yeah when a missile hits the Pentagon i mean an airplane"

[Jundam]

It would definitely not surprise me if they tried it on humans before they began clinical trials. After all, if they can determine if it works or not off the records they either know it's not going to work and can scrap the project and save a lot of time and money, or they know it's got a lot of potential and can move forward with confidence.

[uninformed]

Didnt mean to stir up any bickering and I suppose i should of clarified that the hype for "potential" results is primarily from the hair loss community.

My question was more have ever been this "seemingly" close? I realize that there is no official human evidence yet but I am wrong to be a bit excited about the potential?

yeh sorry if it sounded like i was being harsh. We are all in the same boat here and I think we all hope for the best. They are probably pretty sure in terms of whether it works on humans, since ARI threw more than 100 million dollars into it =P

[Losing_It]

Didnt mean to stir up any bickering and I suppose i should of clarified that the hype for "potential" results is primarily from the hair loss community.

My question was more have ever been this "seemingly" close? I realize that there is no official human evidence yet but I am wrong to be a bit excited about the potential?

No worries, Dawkins tend to go wild some time. There are some real stuff coming down pipeline. Lets just say if Spencer is confident then I am also confident

[RichardDawkins]

Btw didnt spencer promise to give us an IHRS update? :-)

[UK Boy]

I know this is a couple of weeks old but I didn't see anyone post it on here so thought it might be of some interest.

Atlanta, GA (PRWEB) October 20, 2011

Aderans Research reached a major milestone in its hair restoration studies recently when the company enrolled its 300th subject in Phase 2 of its clinical trial. With a goal of at least 350 subjects, Aderans is well on its way to expanding industry knowledge about cell-based engineering solutions for pattern hair loss.

“We will continue to evaluate various combinations of the Ji Gami™ cell family in clinical treatment regimens,” said Chief Executive Officer Ken Washenik, M.D., Ph.D.

“The results are very encouraging thus far, and we’re on course to finish Phase 2 next year,” added Vern Liebmann, Chief Operating Officer.

Launched in November 2008, Phase 2 is being conducted across the United States and is open to select individuals who suffer from androgenetic alopecia. Aderans continues to recruit subjects; visit http://www.aderansresearch.com/ari_clinicupdates.html for current locations.

In another landmark, Aderans recently patented (U.S. # 7,985,537) and trademarked its proprietary laboratory test, Aderans HPA™, developed to discern and assess cell formulations in terms of their hair-forming ability. “This unique test can effectively detect cells that produce hair follicles,” said Kurt Stenn, MD, Vice President and Chief Scientific Officer. “It is a standard in the industry.”

It is ARI’s hope that its state-of-the-art cell engineering solutions will both positively impact those in the study and set an example for the industry as a whole.

Good to know that they appear to be progressing and that they state they are on track to finish phase II next year. It's also interesting to read about their lab test for assessing the hair forming ability of different formulations - sounds like a useful tool for the hair restoration community to have access to.

[melwou7245]

I know this is a couple of weeks old but I didn't see anyone post it on here so thought it might be of some interest.

Atlanta, GA (PRWEB) October 20, 2011

Aderans Research reached a major milestone in its hair restoration studies recently when the company enrolled its 300th subject in Phase 2 of its clinical trial. With a goal of at least 350 subjects, Aderans is well on its way to expanding industry knowledge about cell-based engineering solutions for pattern hair loss.

“We will continue to evaluate various combinations of the Ji Gami™ cell family in clinical treatment regimens,” said Chief Executive Officer Ken Washenik, M.D., Ph.D.

“The results are very encouraging thus far, and we’re on course to finish Phase 2 next year,” added Vern Liebmann, Chief Operating Officer.

Launched in November 2008, Phase 2 is being conducted across the United States and is open to select individuals who suffer from androgenetic alopecia. Aderans continues to recruit subjects; visit http://www.aderansresearch.com/ari_clinicupdates.html for current locations.

In another landmark, Aderans recently patented (U.S. # 7,985,537) and trademarked its proprietary laboratory test, Aderans HPA™, developed to discern and assess cell formulations in terms of their hair-forming ability. “This unique test can effectively detect cells that produce hair follicles,” said Kurt Stenn, MD, Vice President and Chief Scientific Officer. “It is a standard in the industry.”

It is ARI’s hope that its state-of-the-art cell engineering solutions will both positively impact those in the study and set an example for the industry as a whole.

Good to know that they appear to be progressing and that they state they are on track to finish phase II next year. It's also interesting to read about their lab test for assessing the hair forming ability of different formulations - sounds like a useful tool for the hair restoration community to have access to.

Just to confirm, this is the treatment where they take your own stem cells out of your own bone marrow, do a tequila mix, inject it back and your old dead hair follicles pull a zombie move and become active again?

So it's in phase II - how many phases are there going to be? Also any idea on the possible cost?

Also, even if they revive old dead hair follicles, won't the DHT just kill them again?

[Kampung101]

Just to confirm, this is the treatment where they take your own stem cells out of your own bone marrow, do a tequila mix, inject it back and your old dead hair follicles pull a zombie move and become active again?

So it's in phase II - how many phases are there going to be? Also any idea on the possible cost?

Also, even if they revive old dead hair follicles, won't the DHT just kill them again?

I'm not sure about the bone marrow, but they do something very similar to Replicel in that they take a small biopsy from the back of the head where the hair cells are resistant to DHT. The difference is that Aderans is taking the DP cells, whereas Replicel is taking the Dermal Cup cells.

And the revived old hair follicles should be permanent as the newly implanted DHT resistant cells are migrating to those follicles.

Thats at least my understanding of this.

[melwou7245]

I'm not sure about the bone marrow, but they do something very similar to Replicel in that they take a small biopsy from the back of the head where the hair cells are resistant to DHT. The difference is that Aderans is taking the DP cells, whereas Replicel is taking the Dermal Cup cells.

And the revived old hair follicles should be permanent as the newly implanted DHT resistant cells are migrating to those follicles.

Thats at least my understanding of this.

OK, that's pretty concise, thanks. My second question - these Dermal Cup cells and DP cells, where do they get them? From your body, or cooked up in a lab?

[Kampung101]

OK, that's pretty concise, thanks. My second question - these Dermal Cup cells and DP cells, where do they get them? From your body, or cooked up in a lab?

The cells are from your own body. The lab is where they'll be multiplied at, and then all those cells will be injected into your scalp.