Replicel

[depressed17]

This stuff sounds amazing. Sorry if it's been posted already but its definitely worth being posted again ! The human trails have already began December last year.
http://www.replicel.com/our-science/how-our-science-works/

[UK Boy]

Replicel was Trichoscience so it has been talked about but it's still good stuff

[UK_]

I was going to post this yesterday also:

http://www.replicel.com/

Looks pretty good.

[UK_]

RepliCel’s pre-clinical studies have demonstrated that cultured dermal sheath cup cells are capable of directly reconstituting the dermal papilla (DP) and promoting the development of mature hair follicles. During these studies, dermal sheath cup cells migrated into pre-existing hair papilla and also formed completely new hair follicles

Interesting, as opposed to Intercytex that went head-on into replicating DP cells, it seems Replicel are trying a far different strategy by building the follicle from the ground up by multiplying and injecting dermal sheath cup (DSC) cells, and it has shown to be effective in mouse model, i'd love to hear Spencer have an interview with a representative of Replicel after the completion of Phase I/II or even before!

[petewete]

This looks awesome! Does anybody know when/if the results of the Phase 1 trials will be released. Also, this looks like a European company, do things move faster there?

[Mojo Risin]

It's a Canadian company, they're in Vancouver.

[KeepHoping]

Do you guys think this is the real deal? Their staff has fantastic credentials and their website is nicely presented.

[UK_]

Do you guys think this is the real deal? Their staff has fantastic credentials and their website is nicely presented.

I believe companies like this are totally legit, they are registered companies, have credible researchers, investors, FDA trials etc - its companies like Bioregenerative Sciences and the producers of CyGenX that really piss me off.

[Flowers]

This does seem very exciting have they given a timetable on anything yet?

[Latitude]

Update from RepliCel..

http://www.replicel.com/replicel-update-on-first-in-human-clinical-trial-ts001-2009/

[UK_]

Update from RepliCel..

http://www.replicel.com/replicel-update-on-first-in-human-clinical-trial-ts001-2009/

"RepliCel’s hair-cell replacement procedure is now undergoing further rigorous study to determine effectiveness. The first human clinical trials (Phase I/IIa) began in Europe in December 2010. Canadian clinical trials are planned for 2012, with further European trials to follow."

So phase II starts in January im guessing - still - this one seems a long way off.

I wonder if they can scrape under Aderans' timeline and beat them to market before 2014, the first company to get to market with something like this will blow the industry away.

[Flowers]

They said final data analysis is Q3 2011. So thats a little over 2 years from now. We'll see....

[CVAZBAR]

This is also promising. Wouldn't it be great if we knew that this worked perfectly with fantastic results. Even if it was 3-4 years away, I would be much relaxed. I would be very happy waiting for this to come out.

[CAlex]

this definitely looks to be a long ways away before it hits market. neither this or histogen have even begun trials, doesnt this mean that the earliest these treatments could get released is like 2017 ? I am always confused by people saying crazy 2 years release dates because dont trials take many years?

[wilymon]

wow, this is great! but I wonder how much it'll cost... :confused:

[Flowers]

this definitely looks to be a long ways away before it hits market. neither this or histogen have even begun trials, doesnt this mean that the earliest these treatments could get released is like 2017 ? I am always confused by people saying crazy 2 years release dates because dont trials take many years?

Did you read my post? They said final data analysis will be Q3 2013

[Latitude]

The most promising component is we will have preliminary data in early 2012. We’ll know if they are onto something good at that point!

[Latitude]

Did you read my post? They said final data analysis will be Q3 2013

I read your post, it says Q3 2011! Typo :p

[UK_]

I read your post, it says Q3 2011! Typo :p

Actually it is Q3 2013 -

Phase II begins in January 2012 - they wont wait out the full 27 months of Phase I before beginning Phase II - they have stated that Phase II trials shall start in January next year in Canada, during that period follow-ups for Phase I shall continue on into 2013.

[Latitude]

Actually it is Q3 2013 -

Phase II begins in January 2012 - they wont wait out the full 27 months of Phase I before beginning Phase II - they have stated that Phase II trials shall start in January next year in Canada, during that period follow-ups for Phase I shall continue on into 2013.

His original post said 2011, like I said typo, anyhow nevermind.


They said final data analysis is Q3 2011. So thats a little over 2 years from now. We'll see.... .

[Flowers]

Yeah sorry about that typo, guys. I was thinking of another company's results time claim (TRX2) lol

[UK_]

Are we all clear that Flowers made a typo?:D

[CVAZBAR]

Let's say everything goes as planned and they get excellent results. How long after would this be available? I mean wouldn't they extend trials with more subjects? It's only 20 heads right?

[CAlex]

flowers, you dont foresee them having any setbacks at all? They havent even entered phase 1 and you guys think they will have all data by end of 2013? I serious dont see that happening.

I want this as much as the next guy but we keep biting on all these very optimistic time lines and then get disappointed and angry a year later when they are way behind.

earliest I see follica histogen or this hitting market is 2016 but everyone is entitled to their opinion

[RichardDawkins]

Depends on how earlythey did actually start their stuff, they are not forced to tell us exactly when they started, and right now i wont blieve any of those companies with their timelines.

Gut feeling tells me they are aiming for a faster market entrance to grab more money, even thy know there is competition right now. I mean ARI was very slow and calm when it came to news but when Histogen entered the spot and also others, they woke up from their lethargic thing and started to go full frontal.

Its good to have different solutions but i think in the end the patient will be irritated because he wont know which thing suits him best, its to much and to many.

[UK Boy]

CAlex why are you just ignoring the facts? I know we don't know for sure that they'll def keep to the timeline but you've said twice that they haven't even started trials yet which is completely false! They started trials in Dec 10 which means they're about 6 months in.

[UK_]

CAlex why are you just ignoring the facts? I know we don't know for sure that they'll def keep to the timeline but you've said twice that they haven't even started trials yet which is completely false! They started trials in Dec 10 which means they're about 6 months in.

CAlex is right - starting trials means literally beginning the process, all they have done thus far is take biopsies and skin graphs from the 20 patients, this is a pre-trial period, Phase I hasnt even really begun yet.

By the looks of things, I seriously doubt these guys will beat Aderans to market by 2014 if everything for them goes to plan, we havn't heard anything from Aderans in a while, only that they've been discussing their findings across the globe, which is classic "we need investment" behaviour. That said I would never rule out Aderans, they have shown 70%+ increase during Phase II already of their most powerful compound, that is exciting news to share with the world for sure.

Histogen begin recruitment for Phase I/II in a few weeks, granted they have been held back by the devastating tsunami in Japan, but we will know if they have an effective safe procedure by the end of this year, I highly doubt there will be any further safety issues if they can get through this upcoming trial without any hindrance.

Stay positive - in no time like the present have we had the fortune to experience so many potential treatments in the pipeline, and who knows even, an unknown company working away in the shadows out there may crop up with the answer before all of the companies we currently have our eyes on.

[depressed17]

I find it weird how all these companies claim that they're going to release their product roughly at the end 2013/early 2014 just when propecia patent runs out. Very strange indeed.

[CVAZBAR]

UK is right. We have a reason to be grateful knowing different companies are working on something.
The Big 4

ARI
Replicel
Follica
Histogen

Somehow I feel Follica will surprise everyone and come out before anyone since they keep their shit low pro. They always seem to be discovering new shit.

[Flowers]

And what it is they're looking for is, just to clarify, hair multiplication correct? Unlimited donor hair? If so that's amazing however you do have to have hair loss bad enough to need a HT to get this done right?

[UK_]

And what it is they're looking for is, just to clarify, hair multiplication correct? Unlimited donor hair? If so that's amazing however you do have to have hair loss bad enough to need a HT to get this done right?

Yes HM - and even if you are starting off thinning, the cells they inject will create entirely new follicles or migrate to "damaged" follicles and rebuild the follicle.

Sounds cool huh?:cool:

[Flowers]

Yes HM - and even if you are starting off thinning, the cells they inject will create entirely new follicles or migrate to "damaged" follicles and rebuild the follicle.

Sounds cool huh?:cool:

Fuckin right it does

[KeepHoping]

Once recruitment is closed and you've taken a biopsy and taken the punches from the back of the head the trail has absolutely started, I don't know where you got that idea from... Also they have an update on their website that they've actually cultured and reinjected the cells already so now it's really underway. Cross your fingers.

[BoSox]

Science wins (:

You think this will be ready by 2015? Or are we "decades or many years away from HM?" Like most experts think :(

[KeepHoping]

depends on the results of this first trail, because the material needed to be reinjected is derived from the human body it will not have to undergo super strict FDA passage like other products (i.e. Histogen, although they went to Asia where trails move faster). If it works as they anticipate then we have a winner and it could get here before 2015 I believe.

[BoSox]

Better start saving. Can only imagine how expensive this is going to be.

[UK_]

Better start saving. Can only imagine how expensive this is going to be.

Probably double the cost of 3000 grafts from a decent clinic.

[CVAZBAR]

So where is the Replicel interview? Spencer said they had interesting info. When will we hear from them?

[UK_]

So where is the Replicel interview? Spencer said they had interesting info. When will we hear from them?

Spencer has an interview with Replicel? I didnt know that.

Should be well interesting, they finish phase I in six months.

[CVAZBAR]

Spencer has an interview with Replicel? I didnt know that.

Should be well interesting, they finish phase I in six months.

What's up UK, yeah I'm sure he does or he is in the process of doing it. He talked about it in his show and said they had "interesting" info. Joe from Staten island even made a comment in which he said that Replicel might be ahead of everyone. I know we always here shit like this, so it really depends on efficacy. We just need to hope everything goes as planned. Nonetheless, it would definitely be interesting to hear from them.

[Thunderbass]

The video was pretty interesting. I think their process might be the one. If the trials go as well or better than planned maybe 2013 or 2014 will be the year it's released. I bet this process costs $10,000 at least.

[BoSox]

I don't care if it costs an arm or a leg.

As long as the results are there, I'll find a way to finance it.

[DepressedByHairLoss]

Cost was never an issue. If this process works (which doesn't leave scars all over your head), I would even pay $20,000. Having my hair back is absolutely priceless for me. I believe that there are so many people out there like myself who would pay anything to get their hair back, but they don't want their head permanently scarred for life.

[Dasani]

It's my understanding that conventional hair transplants are expensive due to the fact that the procedure requires a significant number of man-hours by technicians trained in microsurgery. This technique seems fundamentally simpler less labour intensive, which could mean hair restoration doctors could charge less, lower the treatment price and treat more patients to gain an overall increase in revenue.

[Flowers]

I know this is slightly off topic but does anyone know anything about the PRP doctor in Canada offering treatment? They have pics on their site and say it's $600 per treatment and you go 3 months after your first treatment and then possibly once a year for maintenance. Check it out at the PRP thread under the histogen thing on the top of the threads. Sounds interesting but I'm skeptical

[Dutch_Dude]

Wait, replicel is what TrichoScience used to be, right? When did they say it'sgoing to come on the market?

[CVAZBAR]

Wait, replicel is what TrichoScience used to be, right? When did they say it'sgoing to come on the market?

If everything goes as planned, they might be out before anyone. They are not going through FDA. They can come out as soon as 2013-14!

[Curlybill99]

so what are replicel planning on doing just doing 2 clinical trials and offering it outside the us.. Lik canada or something.

[BoSox]

If everything goes as planned, they might be out before anyone. They are not going through FDA. They can come out as soon as 2013-14!

That seems early, do you think they are able to release it that soon with good results...or do we have to wait for later generations?

[krewel]

I'm actually really excited about Replicel, because their solution is planned to be a real cure. That's at least the way I have been informed about them. Hope it's gonna work out :)

[CVAZBAR]

That seems early, do you think they are able to release it that soon with good results...or do we have to wait for later generations?

Well I also think it's real early but based on their testing timeline it's a possibility. I personally not expecting it to be that early but I think I remember reading they would be done with trials around late 2013. Maybe I'm wrong but I also remember that being brought up in the TBT show. Maybe someone can verify that.

[Follicle Death Row]

Are they all really aiming for 2014 or do they just have to say 2014 to get investors, especially as company x and company y are aiming for 2014. If we knew for sure there would be a good solution by 2014 many of us could rest a little better. They all sound overly optimistic to me. I could understand if Aderans had a product available by 2014 as they've been at this for ages.

[UK_]

Are they all really aiming for 2014 or do they just have to say 2014 to get investors, especially as company x and company y are aiming for 2014. If we knew for sure there would be a good solution by 2014 many of us could rest a little better. They all sound overly optimistic to me. I could understand if Aderans had a product available by 2014 as they've been at this for ages.

I know... Ive been following Aderans since 2004.

Someone kill me.

[Bronson]

If everything goes as planned, they might be out before anyone. They are not going through FDA. They can come out as soon as 2013-14!

Is not going through the FDA necessarily a good thing? I know the FDA isn't popular around here but the list of products that haven't gone through the FDA is not a list I would want to be on. Also, is there a reason that the Histogen thread is getting a lot more activity? Seems like Replicel is just as likely to work according to their theory.

[Jundam]

Is not going through the FDA necessarily a good thing? I know the FDA isn't popular around here but the list of products that haven't gone through the FDA is not a list I would want to be on. Also, is there a reason that the Histogen thread is getting a lot more activity? Seems like Replicel is just as likely to work according to their theory.

Getting an approval from the FDA isn't really worth anything these days. They are more famous for their incompetence and corruption than their dedication and moral convictions.

As far as Histogen getting more attention it's simply a matter of Histogen having actually proven that they can grow hair on human scalp. Replicel is for the time being an unproven theory. It does have very sound research behind it and animal studies suggest that it will be an effective treatment for human hair loss but it still remains to be proven in clinical trials.

[Losing_It]

I have to agree, Histogen provided some tangible results in the pre-clinical with humans, whilst replicel are yet to produce any human results.

[NeedHairASAP]

I have to agree, Histogen provided some tangible results in the pre-clinical with humans, whilst replicel are yet to produce any human results.

so did renokin

[Losing_It]

so did renokin

I don't know Renokin, but I think you may be comparing apple to oranges

[Dutch_Dude]

I too do not trust the FDA and entities like that. I mean it can be useful as far as side effects go, but I fear that they are there to look out for the interests of big pharmaceutical companies.

[UK_]

I don't know Renokin, but I think you may be comparing apple to oranges

lol so true.

[CVAZBAR]

Is not going through the FDA necessarily a good thing? I know the FDA isn't popular around here but the list of products that haven't gone through the FDA is not a list I would want to be on. Also, is there a reason that the Histogen thread is getting a lot more activity? Seems like Replicel is just as likely to work according to their theory.

If I'm correct, I believe everything is derived from human body. This does not require FDA strict trials. It's not a drug. The setbacks would come from efficacy I guess.

[Dutch_Dude]

that's settled then :). it's weird that they are doing it in georgia...i mean...no offense haha...i didn't expect georgia to be the scientific center of replicel :P.

anyways...too bad they don't have photos...

[Jundam]

Well of course they don't have photos, they just begun clinical trials, which in their case means one treatment session and then they invite the patients back 6 months later to evaluate the results.

I think they're doing it in Georgia for the same reason Histogen is doing it in Singapore; Some countries have loose regulations and restrictions which makes it faster and easier to conduct scientific research and clinical trials there.

[Follicle Death Row]

All the better for us then. Replicel is going to work I feel. As for when they'll perfect it and get it out to us is anyone's guess. I do have one problem with the procedure outlined: Why take a 4mm diameter punch? Could they not get the DSC from taking perhaps 4 1mm diameter punches. I'd rather have a few small dots than a little button scar. I'm getting way ahead of myself here. :D

[Thinning@30]

The country of Georgia is actually trying to promote itself as something of a medical tourism destination where people can get cutting edge treatments before they become available elsewhere. I wonder if Replicel might be released in Georgia following initial trials before it is released in other parts of the world

[CVAZBAR]

I think we need an interview with Replicel!!!! It's been a while since we've had another. We need a Histogen, Lauster, Aderans, Follica ANYTHING new. It's been a while.

[Dutch_Dude]

i didn't know that about georgia. cool. we definately need an interview...sounds very promising.

[Sogeking]

New videos from Replicel!

The Science behind Replicel :
http://www.youtube.com/watch?v=0tHDKT7uZp4

Replicel's Vision :
http://www.youtube.com/watch?v=n8kMghojZw4

Their original video :
http://www.youtube.com/watch?v=cCe5mg7X6zg

Thanks for this to Freddie555 from Hairsite

[NeedHairASAP]

New videos from Replicel!

The Science behind Replicel :
http://www.youtube.com/watch?v=0tHDKT7uZp4

Replicel's Vision :
http://www.youtube.com/watch?v=n8kMghojZw4

Their original video :
http://www.youtube.com/watch?v=cCe5mg7X6zg

Thanks for this to Freddie555 from Hairsite


I wish they'd put some results out instead of pixar movies

or some kind of tangible date

anything but pixar clips and "experts"

[Curlybill99]

Is it possible for replicel to have one successful trial and release this to the public.. Is long as it works and is safe i would have no problem spending my money on this.

[NeedHairASAP]

Is it possible for replicel to have one successful trial and release this to the public.. Is long as it works and is safe i would have no problem spending my money on this.


I don't think its possible... years of testing... even in lax countries in asia

[Dasani]

All the better for us then. Replicel is going to work I feel. As for when they'll perfect it and get it out to us is anyone's guess. I do have one problem with the procedure outlined: Why take a 4mm diameter punch? Could they not get the DSC from taking perhaps 4 1mm diameter punches. I'd rather have a few small dots than a little button scar. I'm getting way ahead of myself here. :D

I gotta say if this procedure works perfectly I am 100% cool with a 4mm punch. haha.

[Dasani]

Awww the videos are saying 'private.' I saw this on my phone earlier as I was out walking around and I was going to watch it now but unfortunately I can't. :(

[Losing_It]

Its is interesting that Replicel notes only Phase 1 and 2 trials on their Website. Does this mean that if successful they could launch after Phase 2?

[MrRyan]

What i don't understand is why this has taken so long for it to get to the human trials stage this was found to be safe and effective years ago in mice, so why only now are human trials being done ? I'm not sure if it was an issue of funding, know how, or my worst fear just not worth the hassle for them if someone could explain i would be grateful.

If i could choose out of all the current trials going on right now which one i would want to succeed it would be this one as is seems very simple and non invasive, but of course efficacy hasn't even been shown in the trial data as of yet so i don't want to get too far ahead of myself. And i'm at the stage now where i just need to know if any of these potential treatments will work and we will know pretty soon within around 6 - 8 months, if it turns out that they don't work i'm just going to accept the fact that i need to buzz my head down and get on with life the best i can, but i will admit this is destroying my confidence and i have dealt with a lot of things in my life and got through them, this however i'm finding very very hard to deal with.

[NeedHairASAP]

Its is interesting that Replicel notes only Phase 1 and 2 trials on their Website. Does this mean that if successful they could launch after Phase 2?


it means we still haven't seen one actual human result... just pixar movies of magic chemicals that float around under your scalp and find sleeping hair follicles

[Jundam]

What i don't understand is why this has taken so long for it to get to the human trials stage this was found to be safe and effective years ago in mice, so why only now are human trials being done ? I'm not sure if it was an issue of funding, know how, or my worst fear just not worth the hassle for them if someone could explain i would be grateful.

If i could choose out of all the current trials going on right now which one i would want to succeed it would be this one as is seems very simple and non invasive, but of course efficacy hasn't even been shown in the trial data as of yet so i don't want to get too far ahead of myself. And i'm at the stage now where i just need to know if any of these potential treatments will work and we will know pretty soon within around 6 - 8 months, if it turns out that they don't work i'm just going to accept the fact that i need to buzz my head down and get on with life the best i can, but i will admit this is destroying my confidence and i have dealt with a lot of things in my life and got through them, this however i'm finding very very hard to deal with.

It's hard to know since they've released no statement regarding it but if I were to make a guess I'd say that their problem was not in finding out how to activate the hair follicles but in finding out how to reach the hair follicles to activate them, and being able to do so consistently and safely. It would make sense if the method of delivery was the problem as once they had solved that problem they could begin clinical trials to prove its potency and then move onto commercial release.

[PinotQ]

There are many reasons why I believe it has taken a long time to get to the clinical trial stage. One reason is that it takes time to raise the necessary funding. Another reason is that it is a lot more complicated than it appears to set up and execute a clinical trial. If you remember, Replicel was over a year late in beginning it's clinical trial after it had raised the necessary funding. If the trial is not set up correctly with the proper protcols and safeguards, the trial results may be useless in the eyes of the regulatory body that is charged with reviewing them. It seems that almost all of the players in this game have had delays in setting up & starting their clinical trials. But I believe the major reason that it has taken so long is that Replicel had to perfect a method of multiplying the cells taken from the punch biopsy into millions of cells for reinjection. If you have read any of the research in this area, one of the problems that had to be overcome was that after a certain number of passes, the cells start to loose their potency and take on an irregular shape. So I think the trick here is turning 1 DSC cell into many DSC cells such that they retain all of their characteristics and potency. Based on everything I have read, I believe Replicel has indentified the correct cell. It remains to be seen how effective their method of replicating these cells will be. One key point that I find highly suggestive of the confidence they have in their possibility of success is that they raised their funding and seemingly came from nowhere, after Aderans was already well into Phase II of their trials.

[MrRyan]

Please forgive my ignorance, but how exactly do the cells know what to do once they are injected is it simply that a cell just does what it does, or does it need other signals from the body to do their job like chemical signals or such like. If so how do they get around this do they use other factors in the injection, i'm sorry if this question sounds stupid, but i'm not very knowledgeable when it comes to human biology.

And one other question i can not for the life of me find one straight answer to is, do the hair follicles die or are they just dormant i'm hoping it's the latter as i'm sure many of you do, i ask this because i think this is massively important for things like Replicel and Histogen in regards to their efficacy.

[UK_]

Please forgive my ignorance, but how exactly do the cells know what to do once they are injected is it simply that a cell just does what it does, or does it need other signals from the body to do their job like chemical signals or such like. If so how do they get around this do they use other factors in the injection, i'm sorry if this question sounds stupid, but i'm not very knowledgeable when it comes to human biology.

And one other question i can not for the life of me find one straight answer to is, do the hair follicles die or are they just dormant i'm hoping it's the latter as i'm sure many of you do, i ask this because i think this is massively important for things like Replicel and Histogen in regards to their efficacy.

Q1 = Because cells are encoded with DNA -

Q2 = Yes, as opposed to scarring alopecia, male pattern hair loss does not destroy the stem cells needed to regenerate the hair follicle, hairs still exist but they are miniaturised even on NW 7 scalps -

[krewel]

Besides, the chief of their team is German. When it comes to technology and science, I absolutley trust those guys. :D
Well, lets hope and cross fingers. In some months we'll know more. Until then, I'll keep myself busy with thinking about Christmas hahahahaha.

[PinotQ]

To add to what UK said, you might find it interesting to read Replicel's patent. http://www.freepatentsonline.com/y2006/0088505.html The patent says that Replicel has tried this process with several different stem cell types: The DSC, the DS (dermal sheath cells) and the dermal papillae (what adreans is using). They have found that the DSC is the only stem cell capable of generating all of the relevant parts of the follicle. Their claim is that the DSC is in fact DNA coded to to produce everything necessary to produce new hairs and rejuvenate damaged follicles.

[CVAZBAR]

REPLICEL contacted Spencer!!!!! Interview coming real soon! Finally

[CVAZBAR]

I suggest for people to post questions to ask the Replicel representative. Spencer will most likely check in and choose some questions from here.

[Curlybill99]

do you know when the interview is going to be?

[stillinHS1994]

REPLICEL contacted Spencer!!!!! Interview coming real soon! Finally

Booyah! Finally some news or updates or whatever....better start thinking of questions

[CVAZBAR]

do you know when the interview is going to be?

I don't know the exact day but Spencer said it will probably happen within this week or maybe on Sunday! It's safe to say it will happen soon though, unless something sudden prevents it.

[Losing_It]

The race is on it seems. Interestingly, Replicel published their paper in 2003 about being able to grow hair on mouse ears and foot pads. Lets hope whoever is successful won't get sued for patent infringements. All this propriety liquid stuff is making me worried. Don't we just hate patents.

Anyways, on an unrelated note, I see Kevin Bacon's middle name is Norwood. At least hes got good hair.

[Dutch_Dude]

Everything is looking good and we are nearing 2012!

[BoSox]

I'm sure the most frequent question will be when will this be available. All I care is about efficiancy... ill wait 5 more years if I have to if I knew what was at the finish line <3

[Follicle Death Row]

I'm sure the most frequent question will be when will this be available. All I care is about efficiancy... ill wait 5 more years if I have to if I knew what was at the finish line <3

Many of us young guys feel exactly this way. Would be great to be rocking a full head of hair again at 30.

[wonderboy]

To add to what UK said, you might find it interesting to read Replicel's patent. http://www.freepatentsonline.com/y2006/0088505.html The patent says that Replicel has tried this process with several different stem cell types: The DSC, the DS (dermal sheath cells) and the dermal papillae (what adreans is using). They have found that the DSC is the only stem cell capable of generating all of the relevant parts of the follicle. Their claim is that the DSC is in fact DNA coded to to produce everything necessary to produce new hairs and rejuvenate damaged follicles.

Which treatment should be able to regenerate
ALL parts of the follicle (i.e., even arrector pili muscle and sebaceous
glands)? Replicel could? And aderans, histogen, acell hair autocloning?

[Follicle Death Row]

Which treatment should be able to regenerate
ALL parts of the follicle (i.e., even arrector pili muscle and sebaceous
glands)? Replicel could? And aderans, histogen, acell hair autocloning?

Dr. Cooley said Acell autocloning produces fully functioning follicles with sebaceous glands. Replicel can, Aderans seemingly. I suppose Histogen achieves this too but maybe someone else can elaborate further.

[clandestine]

Very interesting stuff. I'm optimistic with a healthy dose of skepticism. It will be exciting to learn about future Replicel trial results.

[Follicle Death Row]

Very interesting stuff. I'm optimistic with a healthy dose of skepticism. It will be exciting to learn about future Replicel trial results.

That's the exact right way to be. The technique sounds promising.

[RichardDawkins]

Histogen has failed (website has deleted everything regarding clinical trials and release dates) so do you really think Replicel will provide something? No i surely dont

[Ronin]

I had to sign in to contribute the following: RichardDawkins, why don't you take your negativity and shove it up your arse? You enjoy being pessimistic and negative, go be miserable on your own. Stop trying to bring down others.

[The Alchemist]

Histogen has failed (website has deleted everything regarding clinical trials and release dates) so do you really think Replicel will provide something? No i surely dont


They have not deleted everything; you're blatantly lieing. And if you think they're dead, then there will be no need for you to post in this thread again.

[Jundam]

Histogen has failed (website has deleted everything regarding clinical trials and release dates) so do you really think Replicel will provide something? No i surely dont

And absolutely nobody cares what you think.

[RichardDawkins]

i tell it as i see it. Its tsrange when everything remains the same but strangely only those things vanish :-)

[Follicle Death Row]

Well I will say this. We don't know for definite if the trials are actually up and running in Singapore but we do know one thing for definite: there was definitely a delay. Tough to say what will come of Histogen but I do believe they have come up with a promising concept at the least.

Aderans is still the one that seems most likely to me anyway to come to market within the next 3-5 years. A lot of money behind them and they're doing everything by the book so to speak. Deep in FDA phase 2 trials now.

[Sogeking]

Histogen has failed (website has deleted everything regarding clinical trials and release dates) so do you really think Replicel will provide something? No i surely dont

Congrats. You have won. The prize is baldness. We can even give you a medal if you want ;).
If Dr. Gho is the miracle worker you say he is let me ask you one thing?
Do we really have to believe you(Stevie Dee, Richard Dawkins, whatever) and Iron Man? Two guys that haven't even been to Dr. Gho to try HST.
And if a succesful customer is Sneijder, the photos that were shown do look good. But right side of his donor area is very thin. I've seen the photos hyperlinked on the hairsite and it seems to me treatment with donor regrowth is still not in our grasp.l

Sure maybe Aderans, Histogen, Replicel will fail. But you know what hoping for the best makes me feel better so I'm gonna continue with that. And if they do fail will just continue hoping for Dr. Ronald Lauster.

[krewel]

I suggest we just ignore those guys. As long as we dont, they'll keep posting this sh**. Excuse my language.

[DepressedByHairLoss]

How do we know for sure that Histogen is in a delay? They may have taken a clinical trial page down but we really don't know for sure. As people on here know, I called them earlier today and they said they were just re-arranging the website. They didn't mention any delay or anything like that, but they probably wouldn't even tell me if they were in a delay anyway. I don't think we know either way whether there is a delay or not, but at least we know that they are still up and functioning.

[CVAZBAR]

Even if there's a delay, it has nothing to do with failure. How can they fail when they claim they were starting in july? Ignore that fool. He probably isn't getting enough attention at Hairsite.

Don't understand why they always want to be right. You would figure they would want this as much as everyone. It's like they pray for failure unless it's something they promote. I thought we were all in the same gang?

[Follicle Death Row]

There was a delay but I was always under the impression the trials were just starting a month or two later. I can't find where that info is but it was on the forums somewhere. Would be nice to now if they were in the midst of carrying out their trials now.

[Follicle Death Row]

Even if there's a delay, it has nothing to do with failure. How can they fail when they claim they were starting in july? Ignore that fool. He probably isn't getting enough attention at Hairsite.

Don't understand why they always want to be right. You would figure they would want this as much as everyone. It's like they pray for failure unless it's something they promote. I thought we were all in the same gang?

Yes they said they were starting in July. I think before that it was supposed to be May originally but I can't remember where that info is. Hopefully it's underway.

[Kiwi]

Dawkins has lost his mind.

According to Dawkins, Gho is our last hope. And yet we haven't even seen any photographic proof over a long period of time. I havent seen any evidence to show that what Gho does is any more then a form of FUE that leaves some of the follicle behind that 'might' not die...

Where are the macro photographs?

[worried2568]

Wow, this sounds promising.

I don't see why Replicel isn't keeping us too much up to date. I'm sure they know this, but if this works out, they can become extremely rich, so I'm sure they are hard at work.

As is any company.

[BoSox]

I just hope they are able to grow NORMAL hair.. not thin looking hair. I know some wouldn't mind with Nanogen or w/e concealer they have.


I want my hair back to normal. I can't wait for Spencer's interview!

[amadeus]

Don’t worry about what RichardDawkins says. He doesn't know anything and is just some guy who posts on the forums like he knows what he’s talking about. He probably lives in his parent's garage.:)

Spencer Kobren is the most influential and powerful figure in the world of hair loss so I highly doubt he would even bother conducting an interview with Replicel if it wasn’t for real. Let’s all try to stay positive!

[abb83]

hey sorry i live in australia, it's hard for me to catch the show, and it was 2 hrs lng can anyone pls give me an update on waht was said or tell me around what time the replicel update was given? THANKS!

[PayDay]

Joe from Staten Island gave his weekly update and discussed Replicel. All Kobren said was that he owed them a phone call, because they tried to contact him and he was out of town. He also said that he will be interviewing them at some point soon. I think it was in like the first 20 minutes of last Sunday’s show.

[HelpROGER]

I heard the show last week and Spencer did say that he would be doing an interview with them, but did not say when. @amadeus, I think you are right that Spencer would not be wasting his time if he did not think the Replicel was legit. If it wasn’t for the Bald Truth I would have had a hair transplant with MHR when I didn’t even need it and I would be in a really bad place right now, so I trust everything he says and I’m excited to learn more about Replicel. I hope he does the interview tonight!

[CVAZBAR]

Spencer just confirmed that they set a date this week to do the interview with Replicel and will post it during the week and talk about it next Sunday! I'm listening to the show at this point so I will post anything else for people who can't listen, RIGHT NOW. At this moment some annoying dude named ANDREW is complaining about his hair once again but he has a fucking MOP! That dude needs to grow some balls!

Anyways, good news from Spencer and Replicel!

[Follicle Death Row]

Spencer just confirmed that they set a date this week to do the interview with Replicel and will post it during the week and talk about it next Sunday! I'm listening to the show at this point so I will post anything else for people who can't listen, RIGHT NOW. At this moment some annoying dude named ANDREW is complaining about his hair once again but he has a fucking MOP! That dude needs to grow some balls!

Anyways, good news from Spencer and Replicel!

If it's Andrew Zarian then it's such a joke. Dude is like negative norwood with one of those youngster turned up fringes showing a perfectly straight hairline. It's annoying alright. He's on finasteride as far as I'm aware. Doesn't appear to have any loss whatsoever. Ah sorry about the rant, I'm just jealous of that mop. :D

[Delphi]

If it's Andrew Zarian then it's such a joke. Dude is like negative norwood with one of those youngster turned up fringes showing a perfectly straight hairline. It's annoying alright. He's on finasteride as far as I'm aware. Doesn't appear to have any loss whatsoever. Ah sorry about the rant, I'm just jealous of that mop. :D
Yeah it’s Andrew Zarian, he’s okay, but I do get pissed listening to him bitch about his hair like a little girl. He has more hair then I ever had! I started watching the show that Kobren and him do on Friday night with this other guy. It’s a good show and I’m becoming kind of addicted, but even during that show he bitches about his hair which is always perfect! I think this guy just likes to cry about everything, he’s always complaining about some shit.

[krewel]

Yeah it’s Andrew Zarian, he’s okay, but I do get pissed listening to him bitch about his hair like a little girl. He has more hair then I ever had! I started watching the show that Kobren and him do on Friday night with this other guy. It’s a good show and I’m becoming kind of addicted, but even during that show he bitches about his hair which is always perfect! I think this guy just likes to cry about everything, he’s always complaining about some shit.

So I just googled this Andrew Zarian. This guy seriously cries about his hairline, or are you kidding?

[CVAZBAR]

I had a feeling more people felt the same way. Check it, the dude calls the fucking show and constantly complains that his hair is thinning but has NO signs whatsoever of balding. He comes up with shit like, "my life is over"! I keep thinking the guy is gay. It's so annoying that Spencer even gets to the point where he tells him he is good looking and shouldn't worry. The guy is like a chick that needs to be told he is cute constantly. His whiny voice makes me think he is gay also. I feel like dragging that fool from his hair like a caveman would and then show him that his damn hair ain't falling out! What bothers me more is that he knows Joe from Staten has been suffering for decades and has a very hard time dealing with hair loss and this Andrew dude continues to cry about his mop. Joe deals with clinical depression but this fucking dude ignores it as if Joe wasn't even there. I have a feeling his girl Is going to dump his ass for a real man sooner or later. The guy seems cool but he needs to stop whining like a little girl and consider the people around him.

Anyways, Spencer said to post questions for Replicel.

[hollywoodkid]

Here's a question that has not been asked yet:

Has Replicel done any testing at all, even on mice, that shows that their injectable works in at least some organism? Or is it all just a 'theory' that this will work?

[gmonasco]

Has Replicel done any testing at all, even on mice, that shows that their injectable works in at least some organism? Or is it all just a 'theory' that this will work?

http://www.nature.com/jid/journal/v121/n6/full/5602058a.html

[Follicle Death Row]

I've a few questions. They may not be able to answer them this early in the process but here goes anyway:

1. On an area of bald scalp will an injection of dermal sheath cup cells induce growth of single hairs or multi hair follicles? This is important for producing real volume and the appearance of density.

2. Do the injected cells bring back the old follicles or create entirely new ones? As in if a 3 haired follicle was there before the balding process will that come back or would only a single hair follicle grow?

3. Compared to native non miniturised hair, does the new hair have similiar shaft diameter thickness? Is the shaft thickness similiar to the hair in the donor area?

4. Is the growth direction a non issue?

5. Is the new hair permanent or are repeated procedures or touch ups required periodically? I only ask this as a biopsy is required. We would all like to avoid multiple punches so is it possible that some DSC cells can be kept in a 'hair bank' :D so to speak in order to multiply them again and inject them when the patient requires some time down the line?

6. It's probably too early to ask this one but what sort of density in terms of FU/cm2 can this procedure restore? Are the effects of multiple procedures cumulative? i.e. Would a second pass give the patient more density?

7. Do Replicel forsee the hairline and temple points being problematic? Is there a case here for the synergistic use of a minor FUE session to assert better control over the hairline and ensure the patient the aesthetic result they desire?

8. What timeline are we realistically looking at to get this to market? Is a third phase of clinical trials planned? What's the estimated cost?

9. How come Aderans are going the FDA route with a similiar procedure whereas Replicel are seemingly not?


Hopefully I've laid out some the queries that you guys have too.

[NotDyingBald]

Well, my first post in this forum. Been watchin´it for a while.

About a phase 3 planned, don´t know but, here´s something i haven´t see anyone noticed:

http://www.replicel.com/contact-us/clinical-trials-sign-up/

It´s been on the website for 2 weeks.

"Our clinical team has initiated discussions with regulators in Europe and Canada in anticipation of positive data from our ongoing phase I/IIa clinical trial."

Let´s remember that end of July was the timeline for the injections of all patients in the study. Q1 2012 data, it´s because by then, 6 months passed since the last patient injected. Who knows if, 6 months after the first patient injection(they started Dec`10) they are already seeing good results that makes them think that it´s worth to start planning bigger trials?

Already signed in, since i´m from Europe. :)

[Bronson]

I've a few questions. They may not be able to answer them this early in the process but here goes anyway:

1. On an area of bald scalp will an injection of dermal sheath cup cells induce growth of single hairs or multi hair follicles? This is important for producing real volume and the appearance of density.

2. Do the injected cells bring back the old follicles or create entirely new ones? As in if a 3 haired follicle was there before the balding process will that come back or would only a single hair follicle grow?

3. Compared to native non miniturised hair, does the new hair have similiar shaft diameter thickness? Is the shaft thickness similiar to the hair in the donor area?

4. Is the growth direction a non issue?

5. Is the new hair permanent or are repeated procedures or touch ups required periodically? I only ask this as a biopsy is required. We would all like to avoid multiple punches so is it possible that some DSC cells can be kept in a 'hair bank' :D so to speak in order to multiply them again and inject them when the patient requires some time down the line?

6. It's probably too early to ask this one but what sort of density in terms of FU/cm2 can this procedure restore? Are the effects of multiple procedures cumulative? i.e. Would a second pass give the patient more density?

7. Do Replicel forsee the hairline and temple points being problematic? Is there a case here for the synergistic use of a minor FUE session to assert better control over the hairline and ensure the patient the aesthetic result they desire?

8. What timeline are we realistically looking at to get this to market? Is a third phase of clinical trials planned? What's the estimated cost?

9. How come Aderans are going the FDA route with a similiar procedure whereas Replicel are seemingly not?


Hopefully I've laid out some the queries that you guys have too.

Good questions all, I recommend Spencer ask these to start with.

[elvispresley]

Well, my first post in this forum. Been watchin´it for a while.

About a phase 3 planned, don´t know but, here´s something i haven´t see anyone noticed:

http://www.replicel.com/contact-us/clinical-trials-sign-up/

It´s been on the website for 2 weeks.

"Our clinical team has initiated discussions with regulators in Europe and Canada in anticipation of positive data from our ongoing phase I/IIa clinical trial."

Let´s remember that end of July was the timeline for the injections of all patients in the study. Q1 2012 data, it´s because by then, 6 months passed since the last patient injected. Who knows if, 6 months after the first patient injection(they started Dec`10) they are already seeing good results that makes them think that it´s worth to start planning bigger trials?

Already signed in, since i´m from Europe. :)

replicel looks very good... (we need to see the result) in Q1 2012...

anyway im from europe , can i know what i need to be accepted into the next trials? and where they will do them? i tried to find info on the website but i couldn't ... :( if someone knows let me know thx

[krewel]

What bothers me, well maybe even one of u can answer that:
How will they make sure, that hairs only grow in a certain area? I mean, in their videos it's being said, their techqique also produces new hair follicles. Unfortunatley, we dont want hair to grow out of our forehead, haha.

[uninformed]

What bothers me, well maybe even one of u can answer that:
How will they make sure, that hairs only grow in a certain area? I mean, in their videos it's being said, their techqique also produces new hair follicles. Unfortunatley, we dont want hair to grow out of our forehead, haha.

Yeh was wondering about that too... especially near the hairline, how do you control where the hair growth is gonna be located?

[DepressedByHairLoss]

Well, my first post in this forum. Been watchin´it for a while.

About a phase 3 planned, don´t know but, here´s something i haven´t see anyone noticed:

http://www.replicel.com/contact-us/clinical-trials-sign-up/

It´s been on the website for 2 weeks.

"Our clinical team has initiated discussions with regulators in Europe and Canada in anticipation of positive data from our ongoing phase I/IIa clinical trial."

Let´s remember that end of July was the timeline for the injections of all patients in the study. Q1 2012 data, it´s because by then, 6 months passed since the last patient injected. Who knows if, 6 months after the first patient injection(they started Dec`10) they are already seeing good results that makes them think that it´s worth to start planning bigger trials?

Already signed in, since i´m from Europe. :)

Man, if this was Histogen, I would've signed in in a second. No biopsies or punching, and nothing but potential benefits.

[Kiwi]

Man, if this was Histogen, I would've signed in in a second. No biopsies or punching, and nothing but potential benefits.

Just a quick question, would you personally feel safe being part of a Histogen clinical trial? I sometimes wonder about it myself...

[Follicle Death Row]

Yeh was wondering about that too... especially near the hairline, how do you control where the hair growth is gonna be located?

I wonder the same. Perhaps FUE can play a role in tackling the hairline. Perhaps the first 1 to 1.5cm could be approached using FUE to ensure the aesthetic result the patient wants. Some people have had extensive FUE and their donors have the moth eaten look. I wonder could this Replicel techniqe be used to recharge their donor so to speak to make it look normal.

[Follicle Death Row]

Just a quick question, would you personally feel safe being part of a Histogen clinical trial? I sometimes wonder about it myself...

I don't know about others but I wouldn't want a part in any of the clinical trials. I'll happily take the finished product when they've perfected it but not until then.

[Losing_It]

Man, if this was Histogen, I would've signed in in a second. No biopsies or punching, and nothing but potential benefits.

At the moment beggars can't be chooses. A 4mm punch biopsy won't be so bad if it means a significant amount of hair will grow back and will have . Also Spencer seems really taken by them, so I hope that counts for something.

[krewel]

And something else I ask myself: Are the cells still multiplying under the scalp? Maybe I'm in a total wrong direction, but isn't there a risk to get cancer?

[Follicle Death Row]

And something else I ask myself: Are the cells still multiplying under the scalp? Maybe I'm in a total wrong direction, but isn't there a risk to get cancer?

Cells are multiplied in the lab. It's very safe. That won't be a concern. They're just making more dermal sheath cup cells and putting them back into your scalp. In fact they seem to be able to bypass the FDA with this because it's autologous.

[krewel]

Cells are multiplied in the lab. It's very safe. That won't be a concern. They're just making more dermal sheath cup cells and putting them back into your scalp. In fact they seem to be able to bypass the FDA with this because it's autologous.

FDA = Phase III?

[DepressedByHairLoss]

Kiwi - Normally I am very skeptical of clinical trials but I feel that Histogen's HSC Complex is very safe. However, I wouldn't be a guinea pig for most clinical trials; I would never be a guinea pig for Aderans/Bosley.

Losing It - Agreed. I would exchange a 4mm biopsy for a full head of hair (or something close to it) in a second.

[Losing_It]

Kiwi - Normally I am very skeptical of clinical trials but I feel that Histogen's HSC Complex is very safe. However, I wouldn't be a guinea pig for most clinical trials; I would never be a guinea pig for Aderans/Bosley.

Losing It - Agreed. I would exchange a 4mm biopsy for a full head of hair (or something close to it) in a second.

Well, they managed to find 200 guinea pigs for their Phase II trials. Guess people are really desperate out there. According to that newspaper article 50 to 70 % of the guinea pigs responded well to it. But that the results are comparable to whats currently on the market. So its basically as effective as Fin and Minox. A 1cm biopsy is quite large though, and I am not certain if I would want to undergo multiple 1cm biopsies.

[Follicle Death Row]

FDA = Phase III?

Yeah pretty much. I think they were saying on the podcast that they're not going through the FDA and the Replicel site shows no phase 3. However that all may change.

[elvispresley]

are there any result of the first trials from 2010 ?

[krewel]

Yeah pretty much. I think they were saying on the podcast that they're not going through the FDA and the Replicel site shows no phase 3. However that all may change.

Wow, that means if this works we could see this pretty soon, right? I mean how long does Phase II take, one year? It could be out on 2013!

[Follicle Death Row]

Wow, that means if this works we could see this pretty soon, right? I mean how long does Phase II take, one year? It could be out on 2013!

I doubt it will be out that quickly. They may decide they need to go through a phase 3 or they may do an extended phase 2. 2014 at the earliest I'd imagine but you could be right.

[NeedHairASAP]

can any bio people explain to me how the injected chemicals float all over the head under the scalp and find exactly where they need to go? how do they know what to trigger and what not to trigger? how come they dont float to the back of your neck and start growing a mustache


i want to see evidence not pixar movies

[NotDyingBald]

If you go to the FAQ´s section on Replicel´s website, they say "not possible before 2013".

That´s an important question, how can they control the activation of hair follicles? Vídeo says that the new cells can trigger dormant follicles to re-start producing hair again and also can create new hair follicles.

I think it would be better to trigger only the dormant folicles, and not create new. Because if it creates new, how can they control it? If it only triggers the dormant, issues like thickness and direction of hair growth, could be already solved, since they are already in the position that nature wanted them to be. And we could not be worried about growing hair on our foreheads.

[Follicle Death Row]

If you go to the FAQ´s section on Replicel´s website, they say "not possible before 2013".

That´s an important question, how can they control the activation of hair follicles? Vídeo says that the new cells can trigger dormant follicles to re-start producing hair again and also can create new hair follicles.

I think it would be better to trigger only the dormant folicles, and not create new. Because if it creates new, how can they control it? If it only triggers the dormant, issues like thickness and direction of hair growth, could be already solved, since they are already in the position that nature wanted them to be. And we could not be worried about growing hair on our foreheads.

That's what I'm hoping happens. If that proves to be the case you would think then in theory at least that restoring your childhood density could be possible. I was looking at a picture of myself aged 16 on the day I got my school exam results (happy days) and my hair was amazing. Boy I'd love to get that head of hair back one day.

[krewel]

Well new hairs are always welcome, I never had that thick hair anyway :D I don't think the control of new hair will be a problem though. I mean that's the first thing a normal brain thinks about when it hears about new hair. I mean, after all they are real scientists. They surely thought through it before we did :). It's probably some complicated DNA stuff only biochemists have a clue about, hehe. Still I would really like to know how this new hair growth works without getting out of control.

Just to sum up, and I think everyone wants Spencer to ask them that question:
How does Replicel keep control of the amount and area of new hair growth?

[RichardDawkins]

Nope i would prefer only dormant ones to regenerate because i dont like patchy hair spots :rolleyes:like a botched hair transplant.

Also not before 2013, well i doubt it sorry, i wanna hear the interview first then i decide

[Dasani]

Hey guys, sorry I haven't been paying attention to this thread in a while but I've seen chatter over Spencer doing an interview with Replicel, which sounds great. Any info on when this is expected to occur?

[67mph]

...nobody's started to hold their breath yet right?

[uninformed]

...nobody's started to hold their breath yet right?

Nah I think we all know that the next generation of treatments won't come any earlier than 2013/2014

[Kiwi]

Nah I think we all know that the next generation of treatments won't come any earlier than 2013/2014

I think you're probably right...

[Zoidberg]

Just received this email update, it seems they have dropped a test participant to keep to their desired time frame:

VANCOUVER, BC – September 7, 2011 - RepliCel Life Sciences Inc. is pleased to report that the final study participant has received injections of hair follicle cells prepared using RepliCel™ technology. This milestone marks the end of the treatment phase of the TS001-2009 clinical trial in which a total of nineteen participants received injections. To date, no serious adverse events have been reported post-injection. Please note that recruitment of subjects was closed at nineteen (rather than the planned twenty) to allow for timely processing of interim analysis data from the six-month follow-up time point. This interim analysis is scheduled to take place in Q1, 2012.

[Dasani]

Just received this email update, it seems they have dropped a test participant to keep to their desired time frame:

VANCOUVER, BC – September 7, 2011 - RepliCel Life Sciences Inc. is pleased to report that the final study participant has received injections of hair follicle cells prepared using RepliCel™ technology. This milestone marks the end of the treatment phase of the TS001-2009 clinical trial in which a total of nineteen participants received injections. To date, no serious adverse events have been reported post-injection. Please note that recruitment of subjects was closed at nineteen (rather than the planned twenty) to allow for timely processing of interim analysis data from the six-month follow-up time point. This interim analysis is scheduled to take place in Q1, 2012.

Wow I'm excited to see the results.

[NeedHairASAP]

Just received this email update, it seems they have dropped a test participant to keep to their desired time frame:

VANCOUVER, BC – September 7, 2011 - RepliCel Life Sciences Inc. is pleased to report that the final study participant has received injections of hair follicle cells prepared using RepliCel™ technology. This milestone marks the end of the treatment phase of the TS001-2009 clinical trial in which a total of nineteen participants received injections. To date, no serious adverse events have been reported post-injection. Please note that recruitment of subjects was closed at nineteen (rather than the planned twenty) to allow for timely processing of interim analysis data from the six-month follow-up time point. This interim analysis is scheduled to take place in Q1, 2012.



god help them help me

[NotDyingBald]

Some news from Replicel i received today:

"RepliCel Injects Final Patient with Hair Follicle Cells in its First-In-Man Clinical Trial TS001-2009
VANCOUVER, BC – September 7, 2011 - RepliCel Life Sciences Inc. (the “Company” or “RepliCel”) (OTCBB: REPCF) is pleased to report that the final study participant has received injections of hair follicle cells prepared using RepliCel™ technology. This milestone marks the end of the treatment phase of the TS001-2009 clinical trial in which a total of nineteen participants received injections. To date, no serious adverse events have been reported post-injection. Please note that recruitment of subjects was closed at nineteen (rather than the planned twenty) to allow for timely processing of interim analysis data from the six-month follow-up time point. This interim analysis is scheduled to take place in Q1, 2012.

In the next stage of the TS001-2009 trial, the post-injection follow-up period, subjects return to the study centre to have their health closely monitored to ensure that there have been no adverse effects associated with receiving the injections and to determine the hair growth stimulating efficacy of the hair follicle cell injections.

Once the final patient has completed their six-month follow-up visit, an interim analysis of all collected data will be performed to assess the primary outcome measure of the TS001-2009 study. The analysis will involve assessment of the local (at treatment sites) safety profile of autologous hair follicle cells compared to placebo as defined by AEs with respect to their causality, incidence, severity and seriousness. Secondary outcome measures of systemic (overall) safety (through review of adverse events in a similar fashion as described above) and efficacy (hair growth at treatment sites) will also be performed at this time. Subjects will participate in the post-injection follow-up period of the study until August 2013 and final analysis of safety data should be available in late 2013. "

Six months later from the first patient injection, no side effects. Lets get this safety issue solved and move. :)

[tbtadmin]

Spencer Kobren Speaks With RepliCel Life Sciences' CEO and President David Hall.
(http://www.baldtruthtalk.com/showthread.php?t=6100)

[RichardDawkins]

Ah thank you that was needed

[krewel]

Fuck, 2015? Will it come out earlier in Europe or Asia`?

[Bronson]

Fuck, 2015? Will it come out earlier in Europe or Asia`?

This is a good thing as far as safety is concerned. Remember, it helps everyone involved to get it right the first time. If they rushed it and some minor defects showed up later on, the FDA would squash the whole thing like they've done with cholesterol drugs, etc.

[krewel]

This is a good thing as far as safety is concerned. Remember, it helps everyone involved to get it right the first time. If they rushed it and some minor defects showed up later on, the FDA would squash the whole thing like they've done with cholesterol drugs, etc.

I thought FDA is something thats not needed in Europe and Asia? Shit, this is bad news. I'll be one of RichardDawkins gang now, hahaha.

[Piscium]

Hi, has anyone in the UK signed up for the clinical trials of RepliCel? And if so, have you received any confirmation, notification or communication? Thanks.

[Jundam]

I thought FDA is something thats not needed in Europe and Asia? Shit, this is bad news. I'll be one of RichardDawkins gang now, hahaha.

The FDA has no power outside of the United States.

[kanyon]

Does anyone think they'll have any hair left in 5 years?

[Follicle Death Row]

Does anyone think they'll have any hair left in 5 years?

Yeah. I think I'll have some hair left.....Just not on my head. Another thing I've been wondering about is hair colour. I wonder if you were balding and grey could you restore a head of hair back to the original colour. Suppose it might well be possible but it's not so important. We'd all be more than happy with our hair back. Grey or not.

[BoSox]

why 5 years? isn't this supose to be out 2015, maybe even sooner? I was never really good at math so, idk.

Grey or not, hair can easily be colored.. growing it is a different story.

God I hope this works.. I'll promise to go to church, please space man!

[krewel]

why 5 years? isn't this supose to be out 2015, maybe even sooner? I was never really good at math so, idk.

Grey or not, hair can easily be colored.. growing it is a different story.

God I hope this works.. I'll promise to go to church, please space man!

Yes, it's assumed to be available in 2015 if everything goes by plan. In Europe and Asia, it's probably going to be released earlier.

[Follicle Death Row]

2015. Let's say 4 years. Yes please. I can wait. Hard to imagine that there really could be an infinitely better solution out in just 4 years. I'm optimistic for sure but I'd better not getting my hopes up too high just in case. All the same they do sound quietly confident.

[BoSox]

I agree.. let's all just remain confident as well.. it may be coming out in 4 years, but we'll know for sure what it's all about in a year from the data.


(:

[RichardDawkins]

We will see thats for sure

[Nick_Mannfried]

It looks like RepliCel has updated their video links. The new ones are here:

http://youtu.be/cCe5mg7X6zg
http://youtu.be/DTzbqa3WFmI
http://youtu.be/D8DtIVIA_3g

And there's a new interview with Tobin Smith on their video page:

http://www.replicel.com/media/videos/

[Kiwi]

Yes, it's assumed to be available in 2015 if everything goes by plan. In Europe and Asia, it's probably going to be released earlier.

No its probably not...

So far the facts are as follows
1) replicel have proven its good at growing hair on mice ears
2) have finished their phase 1 clinical trials to test for safety
3) those results are not in until next year

Then Replicel have the big clinical trials ahead that take years, if you dont believe me check out the timeline on the aderans site.

Also histogen said the same thing 2 or 3 years ago when they were where Replicel is now. And there aint nobody buying histogen in china right now.

Aderans and Histogen are our closest bets right now. Start saving your pennies chaps ;)

[clandestine]

How expensive can we expect either of the three treatments will be?

[BoSox]

How expensive can we expect either of the three treatments will be?

Considering the results are permanent, and a cure. It will cost an arm and a leg, but at least you'd be a sexy looking amputee.

[RichardDawkins]

Assumptions, do you think they offer this for 20.000 bucks? If they are aiming for mass market?

No they wont because they are not stupid

[Tracy C]

Mr. Hall stated that they expect it to be competitive with current hair restoration surgeries.

In the case of Replicel, I feel a genuine desire to help the many women who suffer with hair loss. With that in mind, I feel they will do the best they can to make is as affordable as possible.

[clandestine]

Cool, thanks for your thoughts.

[Kiwi]

Kiwi you may have right BUT...
"Replicel" know that it is a big compatition. It is obvies that if Aderans, Histogen,Replica or another company bring a cure that another one like Replicel won't be needed. That's why i don't think that they are going to wait so long because they want to be first like everyone here. And it is good but from outher hand let's hope that all of them will focus on QUALITY not SPEED of put into the market.

I honestly don't think they have any say in the speed at which they will hit the market. That will be up to the FDA in America (for the USA market). Who can say for other parts of the world - heck I'd host them in my back yard in New Zealand if I thought it would speed things up but I honestly don't think it would.

Everybody is welcome to their own thoughts on this but mine are that obviously the first to market will make the most, but all the companies as they hit the market will make millions and millions of dollars.

In the same way that right now a consumer can choose whether they buy a Mac or a PC. Or any type of car brand. Or the same way the consumer can choose from a different shampoo company. The market is big enough to make all these companies very very rich.

[BMT]

The thing to remember is replicel are also testing for results in Phase 1 by giving a high dose. We will know next March if this is going to be something special. If it is, they may still beat the others to market - which is what id assume they are aiming for. Although there's money in it if for everybody, the first company to go to market with a benchmark treatment will be at an advantage.

Histogen didn't blow anybody away with their phase 1 results. So they are refining their technique, as are Aderans. The hope is that Replicel will acheive better phase 1 results and be able to go to market after phase 2 in asia.

[Tracy C]

The market is big enough to make all these companies very very rich.

If they can restore my hair to its former beauty, they deserve it. I am also concerned and hopeful on behalf of my niece’s. Unfortunately they could have inherited this curse as well. :(

[UK Boy]

RepliCel to Present at the 4th Annual LD MICRO Growth Conference in Los Angeles, California
December 1, 2011, Thursday
Contributed by Marketwire

Dec 01, 2011 VANCOUVER, BRITISH COLUMBIA ,MARKETWIRE
RepliCel Life Sciences Inc. (the "Company" or "RepliCel") (OTCBB: REPCF) is pleased to report that David Hall, CEO will be presenting at the LD MICRO Growth Conference on Thursday, December 8th at 3:30pm PDT. Mr. Hall's presentation will introduce RepliCel's autologous hair cell replication technology to over 150 institutions attending this two-day conference where some of the fastest growing companies on the OTC, NASDQ and NYSE are featured.

About LD MICRO

LD MICRO is a by-invitation only newsletter firm that focuses on finding undervalued companies in the micro-cap space. Since 2002, the firm has published an annual list of recommended stocks as well as comprehensive reports on select companies throughout the year. LD MICRO concentrates on finding, researching, and investing in companies that are overlooked by institutional investors. It is a non-registered investment advisor.

I know this doesn't tell us anything more about Replicel's trials or results so some people will probably shoot me down for posting it saying it tells us nothing interesting. However I feel it is interesting because once more it shows the growing interest there seems to be in Replicel's treatment. It also looks like it will be an opportunity for them to gain new investment which is always a good thing. I can't help but feel that with the amount of promotion Replicel are doing it's got to mean they have a very strong idea that they have something good. Maybe I'm being too optimistic but until we know otherwise I think it's better to be positive than negative.

[Jundam]

I agree with that last paragraph. While it does not tell us anything new about the treatment it is good to see that they are putting in work outside of the lab as well. It most definitely looks like an effort to establish themselves and draw attention to their project.

[Have Hope3]

I understand that Replicel is going to post their phase 1 results sometime in February/March, but does anyone know when they plan on starting the phase 2 trails? I thought I remember something about them starting phase 2 in mid 2012 sometime. I guess I'm not even sure if you can start phase 2 that soon after phase 1. Aderans and Histogen seem to be a bit ahead of them in the trials, but replicel really seems to be heading in the right direction. If anyone can answer my question I would greatly appreciate it. Thanks

[TxRockClimber]

Have Hope3, I believe that RepliCel indicated the dosing trial (Phase II) would start sometime in Fall 2012 but could be wrong. If you go back and search the archives - I believe that someone provided an definitive answer to your question.

[Mojo Risin]

Still 10 years away.

[Kiwi]

Still 10 years away.

What is? Your balls dropping? You getting laid (thats not likely to happen), or you getting a HT and getting your hair back (that seems unlikely too).

[UK Boy]

Still 10 years away.

Why bother posting if you've got nothing constructive to say? Why just post stupid, negative things? You clearly have no life and nothing better to do. if you really believe it's 10 years til anything comes out then why are you wasting your time on the forum? Can't you just go join the other Trolls on Hairsite and leave this forum for normal people?

[RichardDawkins]

I agree go visit Hair Site, this is the number one forum for trolls.

[Follicle Death Row]

His avatar is the internet troll face. Don't feed the trolls.

[Mojo Risin]

My avatar is the biggest troll in this industry : George Cotsarelis.

Lauster from the Berlin Technical University said it was 10 years away. Just stating facts. Replicel have been around for how many years ? They're not even done with phase 1. You think a cure is around the corner ? We're not even close. Sorry for bursting your bubble.

[clandestine]

Jesus man, you're so fucking negative for some reason. I feel so sorry for you.

[alex123]

No its probably not...

So far the facts are as follows
1) replicel have proven its good at growing hair on mice ears
2) have finished their phase 1 clinical trials to test for safety
3) those results are not in until next year

Then Replicel have the big clinical trials ahead that take years, if you dont believe me check out the timeline on the aderans site.

Also histogen said the same thing 2 or 3 years ago when they were where Replicel is now. And there aint nobody buying histogen in china right now.

Aderans and Histogen are our closest bets right now. Start saving your pennies chaps ;)
Even if Replicel works to some extent (which is a big if!), there's no way it's going to be out before 2016-17.

[BoSox]

Reading negative comments is depressing, but then I realize the people posting have really no credibility.

Nobody knows the exact day of release, can we just focus on day to day and wait to see what Replicel has to offer in their data? Sheesh.

[Mojo Risin]

Jesus man, you're so fucking negative for some reason. I feel so sorry for you.

I'm just not feeding myself with illusions like the rest of you. The truth hurts, I know.

[Follicle Death Row]

Lauster was talking about lab grown follicles I thought. As in ex vivo. I might be wrong though.

[clandestine]

Even if Replicel works to some extent (which is a big if!), there's no way it's going to be out before 2016-17.

Mind telling us why you think that's such a big if?

[clandestine]

I'm just not feeding myself with illusions like the rest of you. The truth hurts, I know.
Sorry mate, there's no truth to your statements. You're being rather pessimistic in your estimations based on the information provided.

Whereas my statements are intrinsically true; that is calling you out on being a pessimistic motherfucker, and stating I feel sorry for you.

[BoSox]

It's sad that people are fighting on a forum about a disease that we all have.

We all want the same thing, can't we just be on the same page?

[Jundam]

My avatar is the biggest troll in this industry : George Cotsarelis.

Lauster from the Berlin Technical University said it was 10 years away. Just stating facts. Replicel have been around for how many years ? They're not even done with phase 1. You think a cure is around the corner ? We're not even close. Sorry for bursting your bubble.

No, you're not stating facts. You're stating an educated guess from one doctor. To pretend there's any factual basis to that statement is simply ignorant and idiotic.

It may be 10 years away if you presume that hair multiplication is the only "cure" for it. However there is reason to believe that the field of regenerative medicine will provide another solution to our problem. This thread is here so that those of us who wish to follow the progress of RepliCel's search for that solution can come together and talk about it and share any new information we find out about it. So please, shut the fuck up.

[Tracy C]

Replicel have been around for how many years ?

Replicel has been working on this for nine years.

[VictimOfDHT]

Every time I hear stupid words like "optimism" and "pessimism" it makes me laugh. Laugh at people who believe in such crap and superstition. People, there is NO such a thing as pessimism or optimism. Only one thing counts- REALITY. To the so-called optimistic people on here, you can be as optimistic as you can but that WON'T change the facts on the ground and it WON'T make a cure or a treatment -IF THERE IS ANY- come out any sooner. Nor does being pessimistic make a cure come late. Do you people think at all ?

[RichardDawkins]

For the record, its very simple

If those treatments can grow at least one single hair, then it is a cure because it can be pushed to an extend where it gives you back your full head of hair.

Take a look at the user

Onceinamillion or ho his name is, he is a slick NW 6 or NW7 and guess what he grows hair back on his chrome dome BIG time, which clearly indicates that hair loss is reversable.

And now pessimists register at hair site or hair transplantation network to be crybabies, but i can tell you one thing, the admins and other balding celebrities are silently waiting for hm to come and they know it works, but pssssssstt

[Mojo Risin]

Replicel has been working on this for nine years.

And they're still in phase 1.
Thanks.
So in 9 years, they'll be done with phase 2 (that phase is actually longer).
Maybe.

[Mojo Risin]

People say it's terrible that there's been no advancement since Minoxidil and Propecia.

Any of you have diabetes ? Insulin has been around for almost a CENTURY. And today, it's still the only treatment available.

Wake up, there's no money to be made from curing diseases.

[krewel]

People say it's terrible that there's been no advancement since Minoxidil and Propecia.

Any of you have diabetes ? Insulin has been around for almost a CENTURY. And today, it's still the only treatment available.

Wake up, there's no money to be made from curing diseases.

Thank you, you lightened us. I think it's time to close this board since it's useless.

..dude seriously?
I TOTALLY don't get guys like you, if you believe what you are saying, what are you doing here?!

[Mojo Risin]

You guys need a reality check once in a while, that's why.

[RichardDawkins]

But definitely not from you. Seek help, you need it. I think you have a messed up head and thats the reason why you are so full of bitterness and frustration.

The argument no money with a cure is btw bullshit we are not talking about a desease you moron with the 4 chan anonymous forever alone troll face

[Mojo Risin]

But definitely not from you. Seek help, you need it. I think you have a messed up head and thats the reason why you are so full of bitterness and frustration.

The argument no money with a cure is btw bullshit we are not talking about a desease you moron with the 4 chan anonymous forever alone troll face

It's an honor coming from the biggest psycho in the hairloss community.

As I can see, baldness = anger issues as well ? Maybe we could study this.

[Tracy C]

And they're still in phase 1.
Thanks.
So in 9 years, they'll be done with phase 2 (that phase is actually longer).
Maybe.

You don't know half as much as you think you do.

Nobody needs a "wake up call". Everyone needs hope. You are doing far more harm than good.

[RichardDawkins]

Biggest Psycho? Well sorry this is already taken by

SpanishDude
Mojo Raisin
Iron.Man
buglar
HanginThere

Sorry even if i could, i am nowhere near to be a psycho like the users above. But thank you your existence will bring another blog entry :-) about psychos

[Mojo Risin]

You don't know half as much as you think you do.

Nobody needs a "wake up call". Everyone needs hope. You are doing far more harm than good.

What's wrong in saying were still a decade away from an alternative ? Unless someone come out from nowhere with a solution.

[RichardDawkins]

Yawn whatever.

I say we ignore this little attention whore and stick to the toppic rather then argueing with a butchered moron

[Mojo Risin]

Yawn whatever.

I say we ignore this little attention whore and stick to the toppic rather then argueing with a butchered moron

I bring the best in you.
I didn't insult anyone, what's wrong with you. So you'd rather have me say that in 3 years, Replicel will succeed, get passed all the FDA process in a breeze and we'll all have a Justin Bieber's haircut.

[RichardDawkins]

You called me lonely faggot a while back.

Dude seriously i am not responsible that you are 22 years old with hair loss

[Mojo Risin]

You called me lonely faggot a while back.

Dude seriously i am not responsible that you are 22 years old with hair loss

''a while back''

Personal attacks bring a lot to the subject.

[re22]

You want everyone to be realistic, yet you are using "ten years away" as your reference point which is just as baseless of a prediction as everyone else's in this thread. Questioning things is fine, and this forum definitely needs to stay levelheaded, but at least provide some substance to back your claims rather than spouting out aimless cynicisms. The only thing worse than a balding loser is a balding loser who gets a kick out of riling everyone up.

[re22]

I don't think you all are balding losers by the way. I love you all.

[skinontop]

:) some of y just missing eating Propecia today lol

[clandestine]

Questioning things is fine, and this forum definitely needs to stay levelheaded, but at least provide some substance to back your claims rather than spouting out aimless cynicisms.

This. Hadn't realized Mr. Mojo Risin was as big of a troll as he has proven to be.

/ignore.

[BoSox]

Anybody know what happened at the presentation last week?

[Kiwi]

Anybody know what happened at the presentation last week?

Yes I do. Nothing.

Nothing but pics of mice with hairy ears, no info on whether it is even slightly beneficial on humans, and talks of a fantasy fast release to market.

Ok I don't know for sure. But I'd put money on it.

[Kampung101]

Yes I do. Nothing.

Nothing but pics of mice with hairy ears, no info on whether it is even slightly beneficial on humans, and talks of a fantasy fast release to market.

Ok I don't know for sure. But I'd put money on it.

How could they say anything about efficacy when they don't even have the data composed from the 1st trial yet?

These people are research scientists, not genies.

[Kiwi]

How could they say anything about efficacy when they don't even have the data composed from the 1st trial yet?

These people are research scientists, not genies.

Exactly. People are like "WOW REPLICEL ARE GOING TO BE FIRST TO MARKET BECAUSE BLAH BLAH BLAH..."

I've been watching this site for over 5 years and I've seen em come and go. I know that first of all Replicel need to prove safety and then that it actually works on humans. And then they start the real FDA process.

Also what pisses me off about these hollow interviews is that Replicel have never said whether it works on humans. All they have said is that things are going well. And I presume that what they mean is that they have administered it to humans and that those humans havent died. Well its a start.

I'm still pretty certain that Aderans and maybe Histogen will come to market first. If Replicel make it to market they will still make hundreds of millions of dollars.

[Kampung101]

Exactly. People are like "WOW REPLICEL ARE GOING TO BE FIRST TO MARKET BECAUSE BLAH BLAH BLAH..."

I've been watching this site for over 5 years and I've seen em come and go. I know that first of all Replicel need to prove safety and then that it actually works on humans. And then they start the real FDA process.

Also what pisses me off about these hollow interviews is that Replicel have never said whether it works on humans. All they have said is that things are going well. And I presume that what they mean is that they have administered it to humans and that those humans havent died. Well its a start.

I'm still pretty certain that Aderans and maybe Histogen will come to market first. If Replicel make it to market they will still make hundreds of millions of dollars.

Well, to be fair, they're limited by what they can say due to the shareholders, and this is true for all companies. And I don't think the interviews are hollow. Sure, we're not hearing what we all hope to hear (i.e. we definitely have a cure here), but its nice to know that they are keeping the balding community informed in some type of a way.

I personally am not going to predict with any type of certainty as to which treatment will come to market first. Some, and maybe even you, will say Aderans will first, based possibly on how far they are in the trials. But if its all about where a treatment is at in the trial phase, then it would make more sense to predict Follica will be the first to come to market as it has actually finished phase 2. Not saying that Follica will be the first to hit the market (if it even does), as again, at this point with all these possible treatments, there is no strong grounding as to predict which ones will come first.

The only guess I have about all this is that I think its likely that at the very least one of these treatments will be successful (saying none of them will work I think engaging in naive cynicism). But as to which will be successful or which will hit the market first is still too big of a question mark.

[Kiwi]

Well, to be fair, they're limited by what they can say due to the shareholders, and this is true for all companies. And I don't think the interviews are hollow. Sure, we're not hearing what we all hope to hear (i.e. we definitely have a cure here), but its nice to know that they are keeping the balding community informed in some type of a way.

I personally am not going to predict with any type of certainty as to which treatment will come to market first. Some, and maybe even you, will say Aderans will first, based possibly on how far they are in the trials. But if its all about where a treatment is at in the trial phase, then it would make more sense to predict Follica will be the first to come to market as it has actually finished phase 2. Not saying that Follica will be the first to hit the market (if it even does), as again, at this point with all these possible treatments, there is no strong grounding as to predict which ones will come first.

The only guess I have about all this is that I think its likely that at the very least one of these treatments will be successful (saying none of them will work I think engaging in naive cynicism). But as to which will be successful or which will hit the market first is still too big of a question mark.

Thanks for your reply. I appreciate it. I know what you're saying about the interviews and how the people being interviewed can only say so much based on the instructions of their board of directors BUT I don't really care about them (they are going to be rich mother fuckers) all I care about is my hair and a flow of useful and meaningful information.

I don't give a roos poo if the Replicel CEO does a nice talk about how he's having a nice day and that he's feeling positive. I just want to know if it works. Or if it looks like its going to work. And to that end most of the interviews are hollow. At least to me. Spencer just asks the same feel good passing of the time questions and don't get us any closer to knowing. I heard the interview and felt hollow and empty afterwards - I felt exactly where I was before I heard the interview or worse.

I had forgotten about Follica. In my mind, the ones that have a product that delivers the results and gets through the FDA process first, will be the first to market. Its logical but like you kinda say it isnt guaranteed :P

[CVAZBAR]

Well, to be fair, they're limited by what they can say due to the shareholders, and this is true for all companies. And I don't think the interviews are hollow. Sure, we're not hearing what we all hope to hear (i.e. we definitely have a cure here), but its nice to know that they are keeping the balding community informed in some type of a way.

I personally am not going to predict with any type of certainty as to which treatment will come to market first. Some, and maybe even you, will say Aderans will first, based possibly on how far they are in the trials. But if its all about where a treatment is at in the trial phase, then it would make more sense to predict Follica will be the first to come to market as it has actually finished phase 2. Not saying that Follica will be the first to hit the market (if it even does), as again, at this point with all these possible treatments, there is no strong grounding as to predict which ones will come first.

The only guess I have about all this is that I think its likely that at the very least one of these treatments will be successful (saying none of them will work I think engaging in naive cynicism). But as to which will be successful or which will hit the market first is still too big of a question mark.

Excellent reply. I agree 100%

[Mojo Risin]

Don't worry guys, in 5-10 years, we should know.

[RichardDawkins]

Ah Mister I am 22 years old and look like 40 thats why i detroy every thread is back here. Go to hair site, there are people of your kind

[UK Boy]

Don't worry guys, in 5-10 years, we should know.


You certainly don't act like a normal adult. Richard said you're 22 but react to people like a school child in a playground, just repeating the say thing over and over to wind others up.

In a previous post you stated that you come on here and say these things to give the rest of us a reality check but what makes you think you have any standing to do so? If an impartial hair specialist who had been allowed to study the work and progress of Aderans, Follica, Histogen and Replicel came on here and spoke then he would have the standing to give us a reality check but you are NO ONE!

I also think Spencer has a lot more standing than yourself, he has access to information and contacts that the rest of us could only dream of. I know he still doesn't know everything but he's said that he's sure a solution is just around the corner and that the old '5 more years' thing is a thing of the past because research has progressed since then. I'm certainly going to listen to what Spencer has to say over what you want to spout out.

Please just F**K off to hairsite and leave this forum alone!

[RichardDawkins]

I second this statement.

Do you really think that all those research companies are so fucking stupid to waste another decade while there is even more and more donor regeneration with CiT or HST or whatever its called?

No thats btw a reason why they rush right now with vast speed.

Oh and if youcome again with the Mouse model in the Replicel case, THIS MOUSE MODEL was used to see which type of cells could have more potential and to not piss into other research companies soup GOD DAMN

[clandestine]

Thirded. I concur, very well said UK Boy.

[CVAZBAR]

Damn! Mojo got out his cage again.

[RichardDawkins]

I think hairsite is sending its spies or something :-)

[BoSox]

When they say dormant hairs can be regenerated, does that apply to a bald scalp or just hair that is really thin and barely visible?

I really hope Replicel can help bald scalps, as of now I have a full head of hair, but its thinning at a fast pace :( I'm afraid by the time Replicel is available I won't be able to benefit from it.

[Kiwi]

When they say dormant hairs can be regenerated, does that apply to a bald scalp or just hair that is really thin and barely visible?

I really hope Replicel can help bald scalps, as of now I have a full head of hair, but its thinning at a fast pace :( I'm afraid by the time Replicel is available I won't be able to benefit from it.

Replicel is a long way off compared to Histogen and Aderans.

[DepressedByHairLoss]

I disagree, I don't think that Replicel is that much further off than Aderans or Histogen. I understand that Aderans and Histogen may be further along in their clinical trials, but I think Replicel has a far more potent and well-researched method than Aderans. The main reason why Aderans's trials have taken so long is because their their clinical trials haven't produced very significant results (I think like 14 hairs per sq/cm). And the hairs that it produced were white and didn't grow in a pattern the way normal hair grows. Granted, 14 hairs are better than no hairs, but 14 hairs is not nearly enough to satisfy any clinical trial for effectiveness (and I think part of Phase II is to prove that the technology is at least somewhat effective). Plus, Replicel's technology promises to do a lot more than Aderans's. I remember when Aderans first started its clinical trials and Washenik said in an interview that its technology would not be able to replace, but instead would be used in conjunction with, the results of a hair transplant. But Replicel is convinced that their technology will totally do away with the need to get a hair transplant, by not only growing new hair follicles but also by repairing damaged follicles that can no longer produce cosmetically significant hair. Therefore, I think that although maybe Aderans's treatment will come out first, I don't think Replicel's treatment will be that far behind. That being said, I am totally glad that there is more than one company working to cure hair loss; that creates competition to produce the best hair loss cure and causes companies not to languish and become complacent in their clinical trials. Although I do believe that whichever company comes out with their treatment first will probably make the most money and receive the most publicity (which is a great incentive for these companies to keep working hard to push through clinical trials), I agree with you when you said in previous posts that there is room for many companies to make millions of dollars with various hair loss treatments. Hair loss is a problem that negatively affects the lives of millions of people and I'm sure many people (including myself) would pay for multiple treatments if it would regrow more of our hair.
I actually have more confidence in Histogen than I do in Aderans. Histogen has produce more significant hair growth in clinical trials, and since they are conducting their trials outside of the U.S., they won't be bogged down by certain unnecessary FDA regulations, and can thereby release their treatment much quicker.

[Kiwi]

I disagree, I don't think that Replicel is that much further off than Aderans or Histogen. I understand that Aderans and Histogen may be further along in their clinical trials, but I think Replicel has a far more potent and well-researched method than Aderans. The main reason why Aderans's trials have taken so long is because their their clinical trials haven't produced very significant results (I think like 14 hairs per sq/cm). And the hairs that it produced were white and didn't grow in a pattern the way normal hair grows. Granted, 14 hairs are better than no hairs, but 14 hairs is not nearly enough to satisfy any clinical trial for effectiveness (and I think part of Phase II is to prove that the technology is at least somewhat effective). Plus, Replicel's technology promises to do a lot more than Aderans's. I remember when Aderans first started its clinical trials and Washenik said in an interview that its technology would not be able to replace, but instead would be used in conjunction with, the results of a hair transplant. But Replicel is convinced that their technology will totally do away with the need to get a hair transplant, by not only growing new hair follicles but also by repairing damaged follicles that can no longer produce cosmetically significant hair. Therefore, I think that although maybe Aderans's treatment will come out first, I don't think Replicel's treatment will be that far behind. That being said, I am totally glad that there is more than one company working to cure hair loss; that creates competition to produce the best hair loss cure and causes companies not to languish and become complacent in their clinical trials. Although I do believe that whichever company comes out with their treatment first will probably make the most money and receive the most publicity (which is a great incentive for these companies to keep working hard to push through clinical trials), I agree with you when you said in previous posts that there is room for many companies to make millions of dollars with various hair loss treatments. Hair loss is a problem that negatively affects the lives of millions of people and I'm sure many people (including myself) would pay for multiple treatments if it would regrow more of our hair.
I actually have more confidence in Histogen than I do in Aderans. Histogen has produce more significant hair growth in clinical trials, and since they are conducting their trials outside of the U.S., they won't be bogged down by certain unnecessary FDA regulations, and can thereby release their treatment much quicker.

It's nice that you think that.

Unfortunately nothing I've seen or heard make me think that you are talking any sense whatsoever. Replicel havent even got 1 human result back. They still might get back to us in 6 months and say "sorry no hairs have grown on humans... but its great for balding mice ears...."

How the hell is that further down the track then Histogen or Aderans dude???

[re22]

Replicel is more or less going all out in their Phase I trials. We will probably have a rather clear idea about them once those results are released.

[clandestine]

Replicel is more or less going all out in their Phase I trials. We will probably have a rather clear idea about them once those results are released.

Q1 2012, let's keep our fingers crossed!

[DepressedByHairLoss]

It's nice that you think that.

Unfortunately nothing I've seen or heard make me think that you are talking any sense whatsoever. Replicel havent even got 1 human result back. They still might get back to us in 6 months and say "sorry no hairs have grown on humans... but its great for balding mice ears...."

How the hell is that further down the track then Histogen or Aderans dude???

First of all dude, don't tell I'm not talking any sense whatsoever. That's total fuckin bullshit talk man. Read what I said dude, I never said that Replicel was further along than Histogen or Aderans. In fact, I even said that Aderans's treatment would probably come out first, but that Replicel would not be far behind. Although Replicel's treatment hasn't been tested on humans yet, their expectations are far beyond anything that has been claimed by anyone else in the past (Osteoscreen, and even Aderans themselves). They claim that their treatment will not only create new follicles but repair damages ones as well; this was never even expected or claimed from anyone else. For this reason, amongst others, I really think that their technology will exceed 14 hairs per sq/cm very easily. Maybe this is just speculation, but I really think that Replicel will live up to expectations. But you're right that nothing is proven just yet, so that's why I said that Aderans's treatment will be released first, but I don't think that Replicel will be far behind them, especially since they won't be bogged down by useless FDA regulations.

[PinotQ]

On paper, Aderans may look like like they are ahead of everyone b/c they are in Phase II. But, as far as we know, they are in Phase II without an effective treatment. From all we can tell, they are simply experimenting inside Phase II for a cellular combination that grows more than scraggly hairs. I wouldn't consider being in Phase II without an effective product much of an advantage over someone in Phase I. We have 4 main companies in the hunt and they are all essentially research companies at this point until one of them comes thru with solid evidence (pictures) verifying a breakthru. I believe the first to have that breakthru will be closer to market than any of the others, regardless of what Phase of testing they are currently in. But until we have that breakthru, timelines mean nothing. All we know now is that Replicel has put a date on when the results of their first human tests will be available and they have an air of confidence. So this is a real and tangible possibility that we can choose to get excited about. But any of the other 3 could be just as close (or just as far depending upon your mindset) to making an announcement about their results. We may be very close or we may still be far. But we have 4 companies making a big effort to find a solution to a problem we are all desperate for and they are working with exponentially more research knowledge that anyone had 5 years ago. As we have seen, you can evaluate all of this any way you like (almost there, no closer than ever, everything is a conspiracy theory) but it my book there are some very good things going on.

[Kiwi]

On paper, Aderans may look like like they are ahead of everyone b/c they are in Phase II. But, as far as we know, they are in Phase II without an effective treatment. From all we can tell, they are simply experimenting inside Phase II for a cellular combination that grows more than scraggly hairs. I wouldn't consider being in Phase II without an effective product much of an advantage over someone in Phase I. We have 4 main companies in the hunt and they are all essentially research companies at this point until one of them comes thru with solid evidence (pictures) verifying a breakthru. I believe the first to have that breakthru will be closer to market than any of the others, regardless of what Phase of testing they are currently in. But until we have that breakthru, timelines mean nothing. All we know now is that Replicel has put a date on when the results of their first human tests will be available and they have an air of confidence. So this is a real and tangible possibility that we can choose to get excited about. But any of the other 3 could be just as close (or just as far depending upon your mindset) to making an announcement about their results. We may be very close or we may still be far. But we have 4 companies making a big effort to find a solution to a problem we are all desperate for and they are working with exponentially more research knowledge that anyone had 5 years ago. As we have seen, you can evaluate all of this any way you like (almost there, no closer than ever, everything is a conspiracy theory) but it my book there are some very good things going on.

Nicely put :)

[NeedHairASAP]

sometimes it seems like none of the big 3 have 5 day work weeks. I mean.. seriously... 5 days went by this week and nobody seems any farther along... hell its been what? 90 days since anyone released any news?--- even the usual shitty worthless news they put out...


what the hell do these people do between 9am and 5pm? I could solve baldness in under a year, given a degree in biology or research, and a 5 day work week.

[Kiwi]

sometimes it seems like none of the big 3 have 5 day work weeks. I mean.. seriously... 5 days went by this week and nobody seems any farther along... hell its been what? 90 days since anyone released any news?--- even the usual shitty worthless news they put out...


what the hell do these people do between 9am and 5pm? I could solve baldness in under a year, given a degree in biology or research, and a 5 day work week.

lol - i'm pretty sure you couldn't, but I'm totally feeling you re the lack of news, i was hoping for a christmas update... sigh :P

[Pate]

Replicel is a long way off compared to Histogen and Aderans.

Depends on their results. Replicel did a lot of pre-clinical work, 10 years or so, so if they can come out in about March 2012 and show scalp results similar to the mouse ear results we've seen... I'd say that would leapfrog them ahead of Aderans and Histogen.

Aderans in particular have had to go back and do their Phase 2 trials again and again, apparently with slowly improving results. Histogen, well, who knows what's going on there, the last we heard suggested they were trialling multiple injections and follow-up injections.

So let's wait until Replicel release their results for this trial. Certainly they started off behind the other two, but with good results they could leapfrog ahead and possibly even move on to the next phase trial while Aderans and Histogen are stuck repeating their Phase IIs.

[Tracy C]

When they say dormant hairs can be regenerated, does that apply to a bald scalp or just hair that is really thin and barely visible?

It is my understanding that a dormant hair follicle is a hair follicle that does not produce any hair at all. It is also my understanding that Replicel’s treatment is expected to stimulate dormant hair follicles to produce hair again. It is also expected to rejuvinate miniaturized hair follicles to enlarge and return to normal terminal hair producing follicles - and it is expected to generate new hair follicles. In show biz this would be called a triple threat.

Folks don't seem to realize that Replicel has been working on resolving human hair loss for over nine years, with a determined focus on resolving female hair loss. They have been studying general hair regenerative medicine for even longer (over 20 years). They know a lot more about it than ya'll think. We may have just recently learned about Replicel but that does not mean they are new to this game. I don't know which biotech company will be first to market, but I feel Replicel has the best solution - especially for women. If it works half as well as expected, it is worth waiting for. I am no more an expect than anyone else participating in this thread, however I do not feel the wait will be as long as folks here are speculating.

On a side note: Just knowing that hair regeneration is on the horizon has relieved my stress over my own hair loss a great deal. That in and of itself is a very important part of recovering from hair loss.

[clandestine]

Anyone else concerned about how Replicel's research seems to cater largely to a female audience, and as such may not develop an entirely appropriate solution for mpb?

[HairTalk]

Anyone else concerned about how Replicel's research seems to cater largely to a female audience, and as such may not develop an entirely appropriate solution for mpb?

Perhaps they're just trying to include a market that isn't very well-comprised within currently-available (2011) therapies; on their Web site, at least, RepliCel does share a video featuring a prospective male (computer-animated) patient.

[WashedOut]

Their treatment should work on either gender.

[Tracy C]

Anyone else concerned about how Replicel's research seems to cater largely to a female audience?

There is no reason to be. The desire to find a better solution for female hair loss is their motivation. The efficacy of Replicel's treatment should be the same - or close to the same - for both males and females.

[TheLongnHairyProphet]

Guys...I've been lurking hairloss forums for over 6 years...reading about research papers...waiting for the cure for hair loss.....seen so many promises....counting the days for the cure to come. At some point I even thought about changing my degree to biomedical eng but ended with electrical eng instead lol (just to be on the safe side if I need money for the cure).


This is the only time I have decided to create an account in any hair loss forum at all to tell you to keep hope alive. I think replicel is the closest we are getting to a real cure (WITHIN OUR BALDING LIFETIME and by that I mean the lifetime of somebody with MPB if u know what i mean) and Replicel is going ALL OUT with their phase 1 trials.

SO FOR ALL YOU NEGATIVE NANCIES ABOUT "THE EFFECTIVENESS"(I might agree with some of the negative nancies about the release though :S ), YOU SHOULD BE HAPPY OR AT LEAST ENJOY THIS 3 MONTHS OF HOPE, EVEN IF IT'S FALSE. Replicel is the ONLY CURE YOU MIGHT SEE/BE ABLE TO USE IN YOUR MISERABLE LIFETIMES.

However there are things that concern me...how will they market this, If they will market this after Phase 2, AND IF they will publish the effectiveness ...even if it's very successful, there will be probably something affecting their market release too. I know bald celebrities will pay Gazillions and are reading this forum as we speak too...

That's where I'm being a negative nancy...as for the effectiveness Im sure it's working as we speak...but might not be the real problem.


'Till April 2012 Guys.

[Follicle Death Row]

You know if this really works Spencer can help Replicel provide the treatment through the best IAHRS clinics. H&W, Rahal, Feller, Shapiro bros, Feriduni etc. I think it would be in the best interest for the patient anway but we'll what happens. That would be a safe platform to get it out to the public initially. That would be my hope.